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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 3/2019

01-12-2019 | ASO Author Reflections

ASO Author Reflections: Identifying Optimal Surgical Candidates in Hepatocellular Carcinoma with Portal Vein Tumor Thrombus

Authors: Jae Uk Chong, MD, Jin Sub Choi, MD, PhD

Published in: Annals of Surgical Oncology | Special Issue 3/2019

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Excerpt

Portal vein tumor thrombosis (PVTT) has been identified in 10–40% of hepatocellular carcinoma (HCC) patients at initial visit. According to the Barcelona Clinic Liver Cancer (BCLC) classification, portal invasion is categorized as an advanced stage with a median survival of 7.9 months. Several modalities have been attempted to increase survival, but overall survival rarely exceeded 1 year, except for surgical resection, with median survival ranging from 9 to 33 months.1 Although the results of upfront surgery seem superior, we should be reminded of the associated high selection bias. …
Literature
1.
Quirk M, Kim YH, Saab S, Lee EW. Management of hepatocellular carcinoma with portal vein thrombosis. World J Gastroenterol. 2015;21:3462–3471.CrossRef
2.
Han KH, Seong J, Kim JK, Ahn SH, Lee DY, Chon CY. Pilot clinical trial of localized concurrent chemoradiation therapy for locally advanced hepatocellular carcinoma with portal vein thrombosis. Cancer. 2008;113:995–1003.CrossRef
3.
Chong JU, Choi GH, Han DH, Kim KS, Seong J, Han KH, et al. Downstaging with localized concurrent chemoradiotherapy can identify optimal surgical candidates in hepatocellular carcinoma with portal vein tumor thrombus. Ann Surg Oncol. 2018;25(11):3308–3315.CrossRef
4.
Lau WY, Lai EC. Salvage surgery following downstaging of unresectable hepatocellular carcinoma: a strategy to increase resectability. Ann Surg Oncol. 2007;14:3301–3309.CrossRef
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Lee HS, Choi GH, Choi JS, et al. Surgical resection after down-staging of locally advanced hepatocellular carcinoma by localized concurrent chemoradiotherapy. Ann Surg Oncol. 2014;21:3646–3653.CrossRef
Metadata
Title
ASO Author Reflections: Identifying Optimal Surgical Candidates in Hepatocellular Carcinoma with Portal Vein Tumor Thrombus
Authors
Jae Uk Chong, MD
Jin Sub Choi, MD, PhD
Publication date
01-12-2019
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue Special Issue 3/2019
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-018-7018-0

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