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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 3/2019

01-12-2019 | Thyroid Cancer | ASO Author Reflections

ASO Author Reflections: Cautious Management of NIFTP

Author: Antoine Eskander, MD, ScM, FRCS(C)

Published in: Annals of Surgical Oncology | Special Issue 3/2019

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Excerpt

Because patients with thyroid cancer have excellent survival results, there has been a recent trend toward treatment de-escalation. In keeping with this trend, a group of thyroid cancer experts recently studied a group of 109 patients with a noninvasive encapsulated follicular variant of papillary thyroid cancer (FVPTC) who underwent lobectomy without radioactive iodine (RAI). They found no evidence of disease recurrence during a median follow-up period of 13 years and suggested a change in nomenclature for this group to noninvasive follicular thyroid neoplasm with papillary-like features (NIFTP).1 Little is known regarding the impact of this new diagnostic category on the incidence and outcomes for patients with thyroid neoplasms. This study aimed to determine (1) the incidence of NIFTP among all well-differentiated thyroid cancers (WDTCs) in Ontario (1991–2000) and (2) predictors of disease-free survival (DFS) comparing patients with FVPTC and NIFTP in a cohort with long-term follow-up evaluation.2 …
Literature
1.
Nikiforov YE, Seethala RR, Tallini G, et al. Nomenclature revision for encapsulated follicular variant of papillary thyroid carcinoma: a paradigm shift to reduce overtreatment of indolent tumors. JAMA Oncol. 2016;2:1023–9.CrossRef
2.
Eskander A, Hall SF, Manduch M, Griffiths R, Irish JC. A population-based study on NIFTP incidence and survival: is NIFTP really a ‘benign’ disease? Ann Surg Oncol. 2019;26:1376–84.CrossRef
3.
Parente DN, Kluijfhout WP, Bongers PJ, et al. Clinical safety of renaming encapsulated follicular variant of papillary thyroid carcinoma: is NIFTP truly benign? World J Surg. 2018;42:321–6.CrossRef
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5.
Cho U, Mete O, Kim MH, Bae JS, Jung CK. Molecular correlates and rate of lymph node metastasis of noninvasive follicular thyroid neoplasm with papillary-like nuclear features and invasive follicular variant papillary thyroid carcinoma: the impact of rigid criteria to distinguish noninvasive follicular thyroid neoplasm with papillary-like nuclear features. Mod Pathol. 2017;30:810–25.CrossRef
Metadata
Title
ASO Author Reflections: Cautious Management of NIFTP
Author
Antoine Eskander, MD, ScM, FRCS(C)
Publication date
01-12-2019
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue Special Issue 3/2019
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-019-07519-0

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