Published in:
01-12-2019 | Gastric Cancer | ASO Author Reflections
ASO Author Reflections: The Prognostic Role of Exosomal PD-L1 in Patients with Gastric Cancer
Authors:
Yibo Fan, MD, PhD, Yunpeng Liu, MD, PhD, Xiujuan Qu, MD, PhD
Published in:
Annals of Surgical Oncology
|
Special Issue 3/2019
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Excerpt
The role of tumor PD-L1 expression in the prognosis of GC still remained to be controversial.
1,2 Except tumor membrane PD-L1, extracellular soluble and exosomal forms of PD-L1 also existed in the tumor microenvironment.
3,4 Previous studies have almost focused on the role of soluble PD-L1 in cancer patients. However, exosome secreted by tumors plays an important role in regulating tumor immune escape. Exosomal PD-L1 might not only inhibit and kill T cells in local tumor microenvironment and even exert its function in the distant area, leading tumor immune escape. However, it is unknown whether gastric cancer cells could secrete exosomal PD-L1, what is the potential effect in gastric cancer patients, and the difference between exosomal PD-L1 and sPD-L1. …
