ASO Author Reflections: Incorporating Adjuvant Radiation into the Treatment Planning for Select Adrenocortical Carcinomas

Excerpt

Adrenocortical carcinoma (ACC) is a rare, yet highly aggressive malignancy. Complete radical extirpation with negative margins remains the mainstay of treatment; however, local recurrence is common.1 With limited options for efficacious systemic therapies, adjuvant radiation has been proposed as a means to reduce high recurrence rates following surgery with curative intent.2 Although historically considered a relatively radiation resistant cancer, recent retrospective series have demonstrated that tumor bed irradiation utilizing modern radiation technology is associated with improved local recurrence rates.3 Due to the infrequency of this disease, most series exploring the role of adjuvant radiation have been limited by small sample size. Therefore, this study examined the utility of adjuvant radiation in the treatment of ACC utilizing a large, population-based dataset. …