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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 3/2018

01-12-2018 | ASO Author Reflections

ASO Author Reflections: Prolonged Immunoparalysis of NK Cells After Surgery

Authors: Leonard Angka, MSc, Rebecca C. Auer, MD, MSc

Published in: Annals of Surgical Oncology | Special Issue 3/2018

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Excerpt

Natural killer (NK) cells of the innate immune system play a central role in initial cancer immunosurveillance, and NK cell function is correlated with cancer occurrence1 and survival in a number of malignancies, including colorectal cancer.2 Postoperative immune suppression has long been recognized by surgeons and has been implicated in susceptibility to postoperative infections and formation of cancer metastases (reviewed by Horowitz et al.3 and Shakhar et al.4). While preclinical murine studies have linked reduced postoperative NK cell cytotoxicity to cancer metastases5 and human studies have confirmed that NK cell cytotoxicity is transiently (~ 1 week) impaired following cancer surgery (reviewed by Angka et al.6), surgeons have questioned whether the degree and duration of impairment are sufficient to permit formation of metastases in cancer patients. …
Literature
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Imai K, et al. Natural cytotoxic activity of peripheral-blood lymphocytes and cancer incidence: an 11-year follow-up study of a general population. Lancet 2000;356(9244):1795–9.CrossRefPubMed
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Tartter PI, et al. The prognostic significance of natural killer cytotoxicity in patients with colorectal cancer. Arch Surg. 1987;122(11):1264–8.CrossRefPubMed
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Tai LH, et al. Preventing postoperative metastatic disease by inhibiting surgery-induced dysfunction in natural killer cells. Cancer Res. 2013;73(1):97–107.CrossRefPubMed
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Tai LH, et al. Phosphodiesterase-5 inhibition reduces postoperative metastatic disease by targeting surgery-induced myeloid derived suppressor cell-dependent inhibition of natural killer cell cytotoxicity. Oncoimmunology 2018;7(6):e1431082.CrossRefPubMedPubMedCentral
Metadata
Title
ASO Author Reflections: Prolonged Immunoparalysis of NK Cells After Surgery
Authors
Leonard Angka, MSc
Rebecca C. Auer, MD, MSc
Publication date
01-12-2018
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue Special Issue 3/2018
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-018-6793-y

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