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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 4/2015

01-04-2015 | Gastrointestinal Oncology

Superiority of the Ratio Between Negative and Positive Lymph Nodes for Predicting the Prognosis for Patients With Gastric Cancer

Authors: Jingyu Deng, MD, Rupeng Zhang, MD, Liangliang Wu, MD, Li Zhang, MD, Xuejun Wang, MD, Yong Liu, MD, Xishan Hao, MD, Han Liang, MD

Published in: Annals of Surgical Oncology | Issue 4/2015

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Abstract

Background

This study aimed to elucidate the prognostic prediction superiority of the ratio between negative and positive lymph nodes (RNP) in gastric cancer (GC).

Methods

The clinicopathologic data of 1,563 GC patients were analyzed to demonstrate the prognostic significances of the RNP stage. The tumor RNP metastasis (TRNPM) classification system also was evaluated to determine the potential superiorities of the prognostic prediction for GC patients.

Results

In the univariate survival analysis, both RNP stage and TRNPM classification were demonstrated to be relative factors in the overall survival (OS) of GC patients. Like the tumor-node-metastasis (TNM) and positive and dissected lymph node (TRPDM) classifications, the TRNPM classification was identified as an independently prognostic predictor of GC patients using multivariate survival analysis. However, TRNPM classification has smaller Akaike information criterion and Bayesian information criterion values than the TNM and TRPDM classifications, and TRNPM classification was demonstrated to be the most intensive indicator for the OS of GC patients using the case–control matched approach, which represented the comparative superiorities of prognostic prediction of TRNPM classification.

Conclusion

The RNP stage should be considered as the optimal variable for evaluating the prognosis of GC in the clinic.
Appendix
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Metadata
Title
Superiority of the Ratio Between Negative and Positive Lymph Nodes for Predicting the Prognosis for Patients With Gastric Cancer
Authors
Jingyu Deng, MD
Rupeng Zhang, MD
Liangliang Wu, MD
Li Zhang, MD
Xuejun Wang, MD
Yong Liu, MD
Xishan Hao, MD
Han Liang, MD
Publication date
01-04-2015
Publisher
Springer US
Published in
Annals of Surgical Oncology / Issue 4/2015
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-014-4121-8

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