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Langenbeck's Archives of Surgery

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01-06-2011 | Original Article

Extended lymphadenectomy improvement of overall survival of gastric cancer patients with perigastric node metastasis

Authors: Jingyu Deng, Han Liang, Dan Sun, Yi Pan, Yong Liu, Dianchang Wang

Published in: Langenbeck's Archives of Surgery | Issue 5/2011

Abstract

Background

The superiority of extended lymphadenectomy for the prognosis of gastric cancer (GC) is still controversial. The authors hypothesized that extended lymphadenectomy could improve the overall survival (OS) of GC patients with a specific extent of lymph node metastasis.

Methods

Data from 456 GC patients who underwent curative gastrectomy with lymphadenectomy were used to illuminate the difference of OS between patients who underwent limited lymphadenectomy and patients who underwent extended lymphadenectomy.

Results

As a whole, there was no significant difference of OS between patients who underwent extended lymphadenectomy and patients who underwent limited lymphadenectomy in all 456 GC patients. However, we demonstrated that extended lymphadenectomy significantly improved the OS of GC patients with perigastric lymph node metastasis (n1 stage based on the Japanese Gastric Cancer Association classification) compared to limited lymphadenectomy (P = 0.023). Furthermore, the more the negative lymph nodes were, the longer the OS of GC patients with perigastric node metastasis following extended lymphadenectomy was (P < 0.001).

Conclusions

Extensive lymph node dissection and good harvest of negative lymph nodes should be deemed as the most important factors to improve the OS of GC patients with perigastric node metastasis.

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Title: Extended lymphadenectomy improvement of overall survival of gastric cancer patients with perigastric node metastasis
Authors: Jingyu Deng
Han Liang
Dan Sun
Yi Pan
Yong Liu
Dianchang Wang
Publication date: 01-06-2011
Publisher: Springer-Verlag
Published in: Langenbeck's Archives of Surgery / Issue 5/2011
Print ISSN: 1435-2443
Electronic ISSN: 1435-2451
DOI: https://doi.org/10.1007/s00423-011-0753-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Extended lymphadenectomy improvement of overall survival of gastric cancer patients with perigastric node metastasis

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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