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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 8/2013

01-08-2013 | Gastrointestinal Oncology

The Prognostic Nutritional Index Predicts Long-term Outcomes of Gastric Cancer Patients Independent of Tumor Stage

Authors: Kazuhiro Migita, MD, Tomoyoshi Takayama, MD, Keigo Saeki, MD, Sohei Matsumoto, MD, Kohei Wakatsuki, MD, Koji Enomoto, MD, Tetsuya Tanaka, MD, Masahiro Ito, MD, Norio Kurumatani, MD, Yoshiyuki Nakajima, MD

Published in: Annals of Surgical Oncology | Issue 8/2013

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Abstract

Purpose

The aim of this study was to investigate the impact of the prognostic nutritional index (PNI) on the long-term outcomes in gastric cancer patients.

Methods

This study reviewed the medical records of 548 patients with gastric cancer who underwent gastrectomy. The PNI was calculated as 10 × serum albumin (g/dl) + 0.005 × total lymphocyte count (per mm3). The receiver operating characteristic (ROC) curve analysis was performed to determine the cutoff value of the PNI. The multivariate analysis was performed to identify the prognostic factors.

Results

The mean PNI was significantly lower in patients with T3–T4 tumors (P < 0.001) and lymph node metastasis (P < 0.001) than in those without such factors. Patients who had a postoperative complication had a lower mean PNI than those without (P = 0.023). When the ROC curve analysis was performed, the optimal cutoff value of the PNI for predicting the 5-year survival was 48. In the multivariate analysis, a low PNI was an independent predictor for poor overall survival (P < 0.001). In the subgroup analysis, the overall and relapse-free survival rates were significantly lower in the PNI-low group than in the PNI-high group among patients with stage I and stage III disease.

Conclusions

The PNI is a simple and useful marker for predicting the long-term outcomes of gastric cancer patients independent of the tumor stage. Based on our results, we suggest that the PNI should be included in the routine assessment of gastric cancer patients.
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Metadata
Title
The Prognostic Nutritional Index Predicts Long-term Outcomes of Gastric Cancer Patients Independent of Tumor Stage
Authors
Kazuhiro Migita, MD
Tomoyoshi Takayama, MD
Keigo Saeki, MD
Sohei Matsumoto, MD
Kohei Wakatsuki, MD
Koji Enomoto, MD
Tetsuya Tanaka, MD
Masahiro Ito, MD
Norio Kurumatani, MD
Yoshiyuki Nakajima, MD
Publication date
01-08-2013
Publisher
Springer US
Published in
Annals of Surgical Oncology / Issue 8/2013
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-013-2926-5

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