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Open Access 01-12-2019 | Thiopental | Original contribution

Neuropharmacological potential of Ceriscoides turgida (Roxb.) leaf and root in mice

Authors: Wahid Hafiz, Md Nazmul Hasan Zilani, Nazneen Ahmeda Sultana, Md Mahmodul Isalm, Md Anisuzzman, Md Golam Hossain

Published in: Clinical Phytoscience | Issue 1/2019

Abstract

Background

Recently, medicinal plants have grabbed attention worldwide in the field of neurosciences for therapeutic intervention. Traditionally, Ceriscoides turgida is used to treat scorpion string, epilepsy, stomachache etc. Present study was designed to peruse neuropharmacological properties of leaf and root extract of C. turgida.

Methods

The neuropharmacological activities were examined by thiopental sodium induced sleeping time, hole cross, hole board and open field tests in mice at the doses of 100 mg/kg and 200 mg/kg body weight.

Results

All the extracts exhibited significant reduction of onset and duration of sleep in thiopental sodium induced sleeping time test. Besides, significant reduction of spontaneous locomotor and exploratory activities was found in both hole cross and open field test. Furthermore, both extracts also decreased the number of head dips by mice in hole-board test.

Conclusion

Altogether, these results suggest that experimental extracts of C. turgida possesses potent CNS depressant and hypnotic properties, which support its use in traditional medicine.

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Title: Neuropharmacological potential of Ceriscoides turgida (Roxb.) leaf and root in mice
Authors: Wahid Hafiz
Md Nazmul Hasan Zilani
Nazneen Ahmeda Sultana
Md Mahmodul Isalm
Md Anisuzzman
Md Golam Hossain
Publication date: 01-12-2019
Publisher: Springer Berlin Heidelberg
Keywords: Thiopental
Diazepam
Published in: Clinical Phytoscience / Issue 1/2019
Electronic ISSN: 2199-1197
DOI: https://doi.org/10.1186/s40816-019-0099-x

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Neuropharmacological potential of Ceriscoides turgida (Roxb.) leaf and root in mice

Abstract

Background

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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