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Open Access 01-12-2017 | Mini review

The BPD trio? Interaction of dysregulated PDGF, VEGF, and TGF signaling in neonatal chronic lung disease

Authors: Prajakta Oak, Anne Hilgendorff

Published in: Molecular and Cellular Pediatrics | Issue 1/2017

Abstract

The development of neonatal chronic lung disease (nCLD), i.e., bronchopulmonary dysplasia (BPD) in preterm infants, significantly determines long-term outcome in this patient population. Risk factors include mechanical ventilation and oxygen toxicity impacting on the immature lung resulting in impaired alveolarization and vascularization. Disease development is characterized by inflammation, extracellular matrix remodeling, and apoptosis, closely intertwined with the dysregulation of growth factor signaling. This review focuses on the causes and consequences of altered signaling in central pathways like transforming growth factor (TGF), platelet-derived growth factor (PDGF), and vascular endothelial growth factor (VEGF) driving these above indicated processes, i.e., inflammation, matrix remodeling, and vascular development. We emphasize the shared and distinct role of these pathways as well as their interconnection in disease initiation and progression, generating important knowledge for the development of future treatment strategies.

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Title: The BPD trio? Interaction of dysregulated PDGF, VEGF, and TGF signaling in neonatal chronic lung disease
Authors: Prajakta Oak
Anne Hilgendorff
Publication date: 01-12-2017
Publisher: Springer Berlin Heidelberg
Published in: Molecular and Cellular Pediatrics / Issue 1/2017
Electronic ISSN: 2194-7791
DOI: https://doi.org/10.1186/s40348-017-0076-8

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

The BPD trio? Interaction of dysregulated PDGF, VEGF, and TGF signaling in neonatal chronic lung disease

Abstract

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

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