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Molecular and Cellular Pediatrics
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Open Access 01-12-2017 | Mini review

The molecular pathophysiology of chronic non-bacterial osteomyelitis (CNO)—a systematic review

Authors: Sigrun Ruth Hofmann, Franz Kapplusch, Katrin Mäbert, Christian Michael Hedrich

Published in: Molecular and Cellular Pediatrics | Issue 1/2017

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Abstract

Chronic non-bacterial osteomyelitis (CNO) belongs to the growing spectrum of autoinflammatory diseases and primarily affects the skeletal system. Peak onset ranges between 7 and 12 years of age. The clinical spectrum of CNO covers sometimes asymptomatic inflammation of single bones at the one end and chronically active or recurrent multifocal osteitis at the other.
Despite the intense scientific efforts, the exact molecular mechanisms of CNO remain unknown. Recent data suggest CNO as a genetically complex disorder with dysregulated TLR4/MAPK/inflammasome signaling cascades resulting in an imbalance between pro- and anti-inflammatory cytokine expression, leading to osteoclast activation and osteolytic lesions.
In this manuscript, the current understanding of molecular patho-mechanisms in CNO will be discussed.
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Metadata
Title
The molecular pathophysiology of chronic non-bacterial osteomyelitis (CNO)—a systematic review
Authors
Sigrun Ruth Hofmann
Franz Kapplusch
Katrin Mäbert
Christian Michael Hedrich
Publication date
01-12-2017
Publisher
Springer Berlin Heidelberg
Published in
Molecular and Cellular Pediatrics / Issue 1/2017
Electronic ISSN: 2194-7791
DOI
https://doi.org/10.1186/s40348-017-0073-y

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