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Open Access 01-12-2018 | Review

Recent advances in hyaluronic acid based therapy for osteoarthritis

Authors: Steven Bowman, Mohamed E. Awad, Mark W. Hamrick, Monte Hunter, Sadanand Fulzele

Published in: Clinical and Translational Medicine | Issue 1/2018

Abstract

Osteoarthritis is a debilitating disease that has increased in prevalence across the world due to the aging population. Currently, physicians use a plethora of treatment strategies to try and slow down the progression of the disease, but none have been shown to ubiquitously treat and cure the disease. One of the strategies uses the high molecular weight molecule hyaluronic acid as either an injectable or oral supplement for treatment. Hyaluronic acid (HA) is a relatively new treatment that has shown varied results through several clinical trials. It can be used as a scaffold for engineering new treatments and several new preparations have just been added to the market. A comprehensive search was conducted through several search databases according our inclusion and exclusion criteria. This review included 44 prospective clinical trial investigating the feasibility and efficacy of HA injection for knee, hip, and ankle osteoarthritis. This review will take a closer look at hyaluronic acid and its properties, as well clinical effectiveness and future options.

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Title: Recent advances in hyaluronic acid based therapy for osteoarthritis
Authors: Steven Bowman
Mohamed E. Awad
Mark W. Hamrick
Monte Hunter
Sadanand Fulzele
Publication date: 01-12-2018
Publisher: Springer Berlin Heidelberg
Published in: Clinical and Translational Medicine / Issue 1/2018
Electronic ISSN: 2001-1326
DOI: https://doi.org/10.1186/s40169-017-0180-3

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Recent advances in hyaluronic acid based therapy for osteoarthritis

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