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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 2/2003

01-03-2003 | Review

Intra-articular hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis: mechanisms of action

Author: Larry W Moreland

Published in: Arthritis Research & Therapy | Issue 2/2003

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Abstract

Although the predominant mechanism of intra-articular hyaluronan (hyaluronic acid) (HA) and hylans for the treatment of pain associated with knee osteoarthritis (OA) is unknown, in vivo, in vitro, and clinical studies demonstrate various physiological effects of exogenous HA. HA can reduce nerve impulses and nerve sensitivity associated with the pain of OA. In experimental OA, this glycosaminoglycan has protective effects on cartilage, which may be mediated by its molecular and cellular effects observed in vitro. Exogenous HA enhances chondrocyte HA and proteoglycan synthesis, reduces the production and activity of proinflammatory mediators and matrix metalloproteinases, and alters the behavior of immune cells. Many of the physiological effects of exogenous HA may be a function of its molecular weight. Several physiological effects probably contribute to the mechanisms by which HA and hylans exert their clinical effects in knee OA.
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Metadata
Title
Intra-articular hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis: mechanisms of action
Author
Larry W Moreland
Publication date
01-03-2003
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 2/2003
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar623

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