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European Journal of Medical Research
Published in: European Journal of Medical Research 1/2021

Open Access 01-12-2021 | Herpes Virus | Case report

A case of Castleman disease with hemophagocytic syndrome derived from HHV8 infection

Authors: Xiao Cui, Yongfeng Wu, Lin Jia, Jing Chang, Chuanyun Li, Caiping Guo, Tong Zhang, Yingmin Ma, Yulin Zhang

Published in: European Journal of Medical Research | Issue 1/2021

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Abstract

Background

For a patient presenting with fever, multiple lymphadenopathy and splenomegaly, pathogen infection should be preferentially considered, followed by lymphoid malignancies. When traditional laboratory and pathological detection cannot find the pathogenic microorganism, metagenomic sequencing (MGS) which targets the person’s genome for exceptional genetic disorders may detect a rare pathogen.

Case presentation

Here, we introduced the diagnostic clue of a case of multicentric Castleman disease (MCD) with hemophagocytic syndrome which was elicited from the detection of human herpesvirus-8 in the blood of a HIV-1 infected person by MGS technology during pathogen inspection. This case highlights the need to increase the awareness of MCD among clinicians and pathologists.

Conclusions

MGS technology may play a pivotal role in providing diagnostic clues during pathogen inspection, especially when pathogens are not detectable by conventional methods.
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Metadata
Title
A case of Castleman disease with hemophagocytic syndrome derived from HHV8 infection
Authors
Xiao Cui
Yongfeng Wu
Lin Jia
Jing Chang
Chuanyun Li
Caiping Guo
Tong Zhang
Yingmin Ma
Yulin Zhang
Publication date
01-12-2021
Publisher
BioMed Central
Published in
European Journal of Medical Research / Issue 1/2021
Electronic ISSN: 2047-783X
DOI
https://doi.org/10.1186/s40001-021-00589-5

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