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European Journal of Medical Research
Published in: European Journal of Medical Research 1/2021

Open Access 01-12-2021 | Severe Acute Respiratory Syndrome Coronavirus | Review

Genetic susceptibility of COVID-19: a systematic review of current evidence

Authors: SeyedAhmad SeyedAlinaghi, Mohammad Mehrtak, Mehrzad MohsseniPour, Pegah Mirzapour, Alireza Barzegary, Pedram Habibi, Banafsheh Moradmand-Badie, Amir Masoud Afsahi, Amirali Karimi, Mohammad Heydari, Esmaeil Mehraeen, Omid Dadras, Jean-Marc Sabatier, Fabricio Voltarelli

Published in: European Journal of Medical Research | Issue 1/2021

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Abstract

Introduction

While COVID-19 pandemic continues to spread worldwide, researchers have linked patterns of traits to poor disease outcomes. Risk factors for COVID-19 include asthma, elderly age, being pregnant, having any underlying diseases such as cardiovascular disease, diabetes, obesity, and experiencing lifelong systemic racism. Recently, connections to certain genes have also been found, although the susceptibility has not yet been established. We aimed to investigate the available evidence for the genetic susceptibility to COVID-19.

Methods

This study was a systematic review of current evidence to investigate the genetic susceptibility of COVID-19. By systematic search and utilizing the keywords in the online databases including Scopus, PubMed, Web of Science, and Science Direct, we retrieved all the related papers and reports published in English from December 2019 to September 2020.

Results

According to the findings, COVID-19 uses the angiotensin-converting enzyme 2 (ACE2) receptor for cell entry. Previous studies have shown that people with ACE2 polymorphism who have type 2 transmembrane serine proteases (TMPRSS2) are at high risk of SARS-CoV-2 infection. Also, two studies have shown that males are more likely to become infected with SARS-CoV-2 than females. Besides, research has also shown that patients possessing HLA-B*15:03 genotype may become immune to the infection.

Conclusion

Combing through the genome, several genes related to immune system’s response were related to the severity and susceptibility to the COVID-19. In conclusion, a correlation was found between the ACE2 levels and the susceptibility to SARS-CoV-2 infection.
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Metadata
Title
Genetic susceptibility of COVID-19: a systematic review of current evidence
Authors
SeyedAhmad SeyedAlinaghi
Mohammad Mehrtak
Mehrzad MohsseniPour
Pegah Mirzapour
Alireza Barzegary
Pedram Habibi
Banafsheh Moradmand-Badie
Amir Masoud Afsahi
Amirali Karimi
Mohammad Heydari
Esmaeil Mehraeen
Omid Dadras
Jean-Marc Sabatier
Fabricio Voltarelli
Publication date
01-12-2021
Publisher
BioMed Central
Published in
European Journal of Medical Research / Issue 1/2021
Electronic ISSN: 2047-783X
DOI
https://doi.org/10.1186/s40001-021-00516-8

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