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European Journal of Medical Research

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Open Access 01-12-2018 | Research

The impact of insulin pump therapy to oxidative stress in patients with diabetic nephropathy

Authors: Xing-Guang Zhang, Yan-Qi Zhang, Qian-Peng Cheng, Yi Cao, Jian-Min Sun, Xiao-Feng Lv

Published in: European Journal of Medical Research | Issue 1/2018

Abstract

Background

The oxidative stress resulting from increased production of ROS plays a crucial role in the development of diabetic complications. We aim to explore the relationships between oxidative stress, diabetic nephropathy (DN) and short-term insulin pump intensive therapy (insulin therapy).

Methods

Levels of 8-hydroxy-deoxyguanosine (8-OHdG), 3-nitrotyrosine (3-NT), glutathione (GSH), superoxide dismutase (SOD) and Interleukin-6 (IL-6) were estimated before and after 2 weeks of insulin therapy in normal group (NC) and type 2 diabetic (DM) with normal albuminuria (NA), microalbuminuria (MA) and clinical albuminuria (CA).

Results

In DM group, levels of 8-OHdG and 3-NT were higher than those in NC group (P < 0.05); GSH and SOD were lower (P < 0.05). And their levels changed with urine albumin–creatinine ratio (P < 0.05). After insulin therapy, these derangements were significantly ameliorated and the changes in NA and MA groups were more significant than CA group (P < 0.05). Correlation analysis showed glycated hemoglobin, the course of disease, the HOME-IR and fasting plasma glucose were positively correlated with 8-OHdG and 3-NT, but negatively correlated with GSH and SOD.

Conclusions

The oxidative stress gradually increased with the magnitude of DN, and insulin pump intensive therapy can significantly ameliorate the derangements in the early stage of DN.

Trial registration NCT03174821

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Title: The impact of insulin pump therapy to oxidative stress in patients with diabetic nephropathy
Authors: Xing-Guang Zhang
Yan-Qi Zhang
Qian-Peng Cheng
Yi Cao
Jian-Min Sun
Xiao-Feng Lv
Publication date: 01-12-2018
Publisher: BioMed Central
Published in: European Journal of Medical Research / Issue 1/2018
Electronic ISSN: 2047-783X
DOI: https://doi.org/10.1186/s40001-018-0304-2

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

The impact of insulin pump therapy to oxidative stress in patients with diabetic nephropathy

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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