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Open Access 01-12-2021 | Nephrotic Syndrome in Children | Research

AGREEing on clinical practice guidelines for idiopathic steroid-sensitive nephrotic syndrome in children

Authors: Khalid Abdulaziz Alhasan, Reem Al Khalifah, Majed Aloufi, Weiam Almaiman, Muddathir Hamad, Naif Abdulmajeed, Abdullah Al Salloum, Jameela A. Kari, Muneera AlJelaify, Rolan K. Bassrawi, Turki Al Hussain, Adi Alherbish, Abdulhadi Al Talhi, Mohamad-Hani Temsah, Sidharth Kumar Sethi, Rupesh Raina, Reny Joseph, Yasser Sami Amer, on behalf of the Saudi Society of Nephrology and Transplantation

Published in: Systematic Reviews | Issue 1/2021

Abstract

Background

Nephrotic syndrome is the most common kidney disease in children worldwide. Our aim was to critically appraise the quality of recent Clinical Practice Guidelines (CPGs) for idiopathic steroid-sensitive nephrotic syndrome (SSNS) in children in addition to summarize and compare their recommendations.

Methods

Systematic review of CPGs. We identified clinical questions and eligibility criteria and searched and screened for CPGs using bibliographic and CPG databases. Each included CPG was assessed by four independent appraisers using the Appraisal of Guidelines for REsearch & Evaluation II (AGREE-II) instrument. We summarized the recommendations in a comparison practical table.

Results

Our search retrieved 282 citations, of which three CPGs were eligible and appraised: Kidney Disease: Improving Global Outcomes (KDIGO) 2012, Japan Society for Pediatric Nephrology (JSPN) 2014, and American Academy of Pediatrics (AAP) 2009. Among these, the overall assessment of two evidence-based CPGs scored > 70% (KDIGO and JSPN), which was consistent with their higher scores in the six domains of the AGREE II Instrument. In domain 3 (rigor of development), KDIGO, JSPN, and AAP scored 84%, 74%, and 41%, respectively. In domain 5 (applicability), they scored 22%, 16%, and 19%, respectively, and in domain 6 (editorial independence), they scored 94%, 65%, and 88%, respectively.

Conclusions

The methodological quality of the KDIGO CPG was superior, followed by JSPN and AAP CPGs with the relevant recommendations for use in practice.

Systematic review registration

The protocol was registered in the Center for Open Science (OSF) DOI: 10.17605/OSF.IO/6QTMD and in the International prospective register of systematic reviews PROSPERO 2020 CRD42020197511.

Available only for authorised users

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Title: AGREEing on clinical practice guidelines for idiopathic steroid-sensitive nephrotic syndrome in children
Authors: Khalid Abdulaziz Alhasan
Reem Al Khalifah
Majed Aloufi
Weiam Almaiman
Muddathir Hamad
Naif Abdulmajeed
Abdullah Al Salloum
Jameela A. Kari
Muneera AlJelaify
Rolan K. Bassrawi
Turki Al Hussain
Adi Alherbish
Abdulhadi Al Talhi
Mohamad-Hani Temsah
Sidharth Kumar Sethi
Rupesh Raina
Reny Joseph
Yasser Sami Amer
on behalf of the Saudi Society of Nephrology and Transplantation
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Nephrotic Syndrome in Children
Pediatrics
Nephrotic Syndrome
Published in: Systematic Reviews / Issue 1/2021
Electronic ISSN: 2046-4053
DOI: https://doi.org/10.1186/s13643-021-01666-w

At a glance: The STEP trials

Springer Medicine

AGREEing on clinical practice guidelines for idiopathic steroid-sensitive nephrotic syndrome in children

Abstract

Background

Methods

Results

Conclusions

Systematic review registration

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

Systematic review registration

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