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Open Access 01-12-2019 | Post-Traumatic Stress Disorder | Research

Long-term neurocognitive outcome is not worsened by of the use of venovenous ECMO in severe ARDS patients

Authors: Aude Sylvestre, Mélanie Adda, François Maltese, Ariane Lannelongue, Florence Daviet, Gabriel Parzy, Benjamin Coiffard, Antoine Roch, Anderson Loundou, Karine Baumstarck, Laurent Papazian

Published in: Annals of Intensive Care | Issue 1/2019

Abstract

Background

Venovenous extracorporeal membrane oxygenation (VV-ECMO) is associated with a significant morbidity. There is the need to investigate long-term cognitive outcome among ARDS survivors treated with VV-ECMO. We aimed to compare the prevalence of long-term cognitive dysfunction and neuropsychological impairment using a highly specific test in severe ARDS survivors treated or not treated with VV-ECMO.

Methods

Severe ARDS survivors treated between 2011 and 2017 in an ECMO Regional Referral Center were prospectively evaluated 2 years after their ICU discharge. Patients underwent an in-person interview and examination. The primary outcome was cognitive function, assessed by the Wechsler Adult Intelligence Scale 4th edition (WAIS-IV). Secondary outcomes included anxiety, depression, post-traumatic stress disorder (PTSD) and quality-of-life.

Results

We investigated 40 consecutive patients surviving from severe ARDS treated (N = 22) or not (N = 18) with VV-ECMO at a median [interquartile range] of 20 [17–22] and 22 [18–23] months after ICU discharge, respectively. Regarding the main outcome, cognitive function was below normal ranges in 12 (55%) ECMO patients and 10 (56%) non-ECMO patients (p = 0.95). Eight (36%) ECMO patients had moderate-to-severe depressive symptoms as compared with 7 (39%) non-ECMO patients (p = 0.87). Twelve (55%) ECMO patients and eight (44%) non-ECMO patients had moderate-to-severe anxiety symptoms (p = 0.53). Seven (33%) ECMO patients and eight (44%) non-ECMO patients presented a PTSD (p = 0.48). Health-related quality of life did not differ between the two groups.

Conclusions

Using the WAIS-IV, VV-ECMO treatment does not appear to worsen long-term cognitive and neuropsychological outcomes in severe ARDS patients.

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Title: Long-term neurocognitive outcome is not worsened by of the use of venovenous ECMO in severe ARDS patients
Authors: Aude Sylvestre
Mélanie Adda
François Maltese
Ariane Lannelongue
Florence Daviet
Gabriel Parzy
Benjamin Coiffard
Antoine Roch
Anderson Loundou
Karine Baumstarck
Laurent Papazian
Publication date: 01-12-2019
Publisher: Springer International Publishing
Keywords: Post-Traumatic Stress Disorder
Acute Respiratory Distress-Syndrome
ECMO
ECMO
Published in: Annals of Intensive Care / Issue 1/2019
Electronic ISSN: 2110-5820
DOI: https://doi.org/10.1186/s13613-019-0556-1

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Long-term neurocognitive outcome is not worsened by of the use of venovenous ECMO in severe ARDS patients

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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