Skip to main content
Top
Published in: Intensive Care Medicine 5/2016

01-05-2016 | Review

Recovery and outcomes after the acute respiratory distress syndrome (ARDS) in patients and their family caregivers

Authors: Margaret S. Herridge, Marc Moss, Catherine L. Hough, Ramona O. Hopkins, Todd W. Rice, O. Joseph Bienvenu, Elie Azoulay

Published in: Intensive Care Medicine | Issue 5/2016

Login to get access

Abstract

Outcomes after acute respiratory distress syndrome (ARDS) are similar to those of other survivors of critical illness and largely affect the nerve, muscle, and central nervous system but also include a constellation of varied physical devastations ranging from contractures and frozen joints to tooth loss and cosmesis. Compromised quality of life is related to a spectrum of impairment of physical, social, emotional, and neurocognitive function and to a much lesser extent discrete pulmonary disability. Intensive care unit-acquired weakness (ICUAW) is ubiquitous and includes contributions from both critical illness polyneuropathy and myopathy, and recovery from these lesions may be incomplete at 5 years after ICU discharge. Cognitive impairment in ARDS survivors ranges from 70 to 100 % at hospital discharge, 46 to 80 % at 1 year, and 20 % at 5 years, and mood disorders including depression and post-traumatic stress disorder (PTSD) are also sustained and prevalent. Robust multidisciplinary and longitudinal interventions that improve these outcomes are still uncertain and data in our literature are conflicting. Studies are needed in family members of ARDS survivors to better understand long-term outcomes of the post-ICU family syndrome and to evaluate how it affects patient recovery.
Literature
1.
go back to reference Ashbaugh DG, Bigelow DB, Petty TL, Levine BE (1967) Acute respiratory distress in adults. Lancet 2(7511):319–323PubMedCrossRef Ashbaugh DG, Bigelow DB, Petty TL, Levine BE (1967) Acute respiratory distress in adults. Lancet 2(7511):319–323PubMedCrossRef
2.
go back to reference Rubenfeld GD, Caldwell E, Peabody E et al (2005) Incidence and outcomes of acute lung injury. N Engl J Med 353(16):1685–1693PubMedCrossRef Rubenfeld GD, Caldwell E, Peabody E et al (2005) Incidence and outcomes of acute lung injury. N Engl J Med 353(16):1685–1693PubMedCrossRef
3.
go back to reference Elliott CG, Rasmusson BY, Crapo RO, Morris AH, Jensen RL (1987) Prediction of pulmonary function abnormalities after adult respiratory distress syndrome (ARDS). Am Rev Respir Dis 135(3):634–638PubMed Elliott CG, Rasmusson BY, Crapo RO, Morris AH, Jensen RL (1987) Prediction of pulmonary function abnormalities after adult respiratory distress syndrome (ARDS). Am Rev Respir Dis 135(3):634–638PubMed
4.
go back to reference Ghio AJ, Elliott CG, Crapo RO, Berlin SL, Jensen RL (1989) Impairment after adult respiratory distress syndrome. An evaluation based on American Thoracic Society recommendations. Am Rev Respir Dis 139(5):1158–1162PubMedCrossRef Ghio AJ, Elliott CG, Crapo RO, Berlin SL, Jensen RL (1989) Impairment after adult respiratory distress syndrome. An evaluation based on American Thoracic Society recommendations. Am Rev Respir Dis 139(5):1158–1162PubMedCrossRef
5.
go back to reference McHugh LG, Milberg JA, Whitcomb ME, Schoene RB, Maunder RJ, Hudson LD (1994) Recovery of function in survivors of the acute respiratory distress syndrome. Am J Respir Crit Care Med 150(1):90–94PubMedCrossRef McHugh LG, Milberg JA, Whitcomb ME, Schoene RB, Maunder RJ, Hudson LD (1994) Recovery of function in survivors of the acute respiratory distress syndrome. Am J Respir Crit Care Med 150(1):90–94PubMedCrossRef
6.
go back to reference Davidson TA, Caldwell ES, Curtis JR, Hudson LD, Steinberg KP (1999) Reduced quality of life in survivors of acute respiratory distress syndrome compared with critically ill control patients. JAMA 281(4):354–360PubMedCrossRef Davidson TA, Caldwell ES, Curtis JR, Hudson LD, Steinberg KP (1999) Reduced quality of life in survivors of acute respiratory distress syndrome compared with critically ill control patients. JAMA 281(4):354–360PubMedCrossRef
7.
go back to reference Heyland DK, Groll D, Caeser M (2005) Survivors of acute respiratory distress syndrome: relationship between pulmonary dysfunction and long-term health-related quality of life. Crit Care Med 33(7):1549–1556PubMedCrossRef Heyland DK, Groll D, Caeser M (2005) Survivors of acute respiratory distress syndrome: relationship between pulmonary dysfunction and long-term health-related quality of life. Crit Care Med 33(7):1549–1556PubMedCrossRef
8.
go back to reference Orme J Jr, Romney JS, Hopkins RO et al (2003) Pulmonary function and health-related quality of life in survivors of acute respiratory distress syndrome. Am J Respir Crit Care Med 167(5):690–694PubMedCrossRef Orme J Jr, Romney JS, Hopkins RO et al (2003) Pulmonary function and health-related quality of life in survivors of acute respiratory distress syndrome. Am J Respir Crit Care Med 167(5):690–694PubMedCrossRef
9.
go back to reference Angus DC, Clermont G, Linde-Zwirble WT et al (2006) Healthcare costs and long-term outcomes after acute respiratory distress syndrome: a phase III trial of inhaled nitric oxide. Crit Care Med 34(12):2883–2890PubMedCrossRef Angus DC, Clermont G, Linde-Zwirble WT et al (2006) Healthcare costs and long-term outcomes after acute respiratory distress syndrome: a phase III trial of inhaled nitric oxide. Crit Care Med 34(12):2883–2890PubMedCrossRef
10.
go back to reference Herridge MS, Tansey CM, Matte A et al (2011) Functional disability 5 years after acute respiratory distress syndrome. N Engl J Med 364(14):1293–1304PubMedCrossRef Herridge MS, Tansey CM, Matte A et al (2011) Functional disability 5 years after acute respiratory distress syndrome. N Engl J Med 364(14):1293–1304PubMedCrossRef
11.
go back to reference Desai SR, Wells AU, Suntharalingam G, Rubens MB, Evans TW, Hansell DM (2001) Acute respiratory distress syndrome caused by pulmonary and extrapulmonary injury: a comparative CT study. Radiology 218(3):689–693PubMedCrossRef Desai SR, Wells AU, Suntharalingam G, Rubens MB, Evans TW, Hansell DM (2001) Acute respiratory distress syndrome caused by pulmonary and extrapulmonary injury: a comparative CT study. Radiology 218(3):689–693PubMedCrossRef
12.
go back to reference Linden VB, Lidegran MK, Frisen G, Dahlgren P, Frenckner BP, Larsen F (2009) ECMO in ARDS: a long-term follow-up study regarding pulmonary morphology and function and health-related quality of life. Acta Anaesthesiol Scand 53(4):489–495PubMedCrossRef Linden VB, Lidegran MK, Frisen G, Dahlgren P, Frenckner BP, Larsen F (2009) ECMO in ARDS: a long-term follow-up study regarding pulmonary morphology and function and health-related quality of life. Acta Anaesthesiol Scand 53(4):489–495PubMedCrossRef
13.
go back to reference Wilcox ME, Patsios D, Murphy G, Kudlow P, Paul N, Tansey CM, Chu L, Matte A, Tomlinson G, Herridge MS (2013) Radiologic outcomes at 5 years after severe ARDS. Chest 143(4):920–926PubMedCrossRef Wilcox ME, Patsios D, Murphy G, Kudlow P, Paul N, Tansey CM, Chu L, Matte A, Tomlinson G, Herridge MS (2013) Radiologic outcomes at 5 years after severe ARDS. Chest 143(4):920–926PubMedCrossRef
14.
go back to reference Angus DC, Musthafa AA, Clermont G et al (2001) Quality-adjusted survival in the first year after the acute respiratory distress syndrome. Am J Respir Crit Care Med 163(6):1389–1394PubMedCrossRef Angus DC, Musthafa AA, Clermont G et al (2001) Quality-adjusted survival in the first year after the acute respiratory distress syndrome. Am J Respir Crit Care Med 163(6):1389–1394PubMedCrossRef
15.
go back to reference Fan E, Dowdy DW, Colantuoni E et al (2014) Physical complications in acute lung injury survivors: a two-year longitudinal prospective study. Crit Care Med 42(4):849–859PubMedPubMedCentralCrossRef Fan E, Dowdy DW, Colantuoni E et al (2014) Physical complications in acute lung injury survivors: a two-year longitudinal prospective study. Crit Care Med 42(4):849–859PubMedPubMedCentralCrossRef
16.
go back to reference Herridge MS, Cheung AM, Tansey CM et al (2003) One-year outcomes in survivors of the acute respiratory distress syndrome. N Engl J Med 348(8):683–693PubMedCrossRef Herridge MS, Cheung AM, Tansey CM et al (2003) One-year outcomes in survivors of the acute respiratory distress syndrome. N Engl J Med 348(8):683–693PubMedCrossRef
17.
18.
go back to reference Weinert CR, Gross CR, Kangas JR, Bury CL, Marinelli WA (1997) Health-related quality of life after acute lung injury. Am J Respir Crit Care Med 156(4 Pt 1):1120–1128PubMedCrossRef Weinert CR, Gross CR, Kangas JR, Bury CL, Marinelli WA (1997) Health-related quality of life after acute lung injury. Am J Respir Crit Care Med 156(4 Pt 1):1120–1128PubMedCrossRef
19.
go back to reference Cheung AM, Tansey CM, Tomlinson G et al (2006) Two-year outcomes, health care use, and costs of survivors of acute respiratory distress syndrome. Am J Respir Crit Care Med 174(5):538–544PubMedCrossRef Cheung AM, Tansey CM, Tomlinson G et al (2006) Two-year outcomes, health care use, and costs of survivors of acute respiratory distress syndrome. Am J Respir Crit Care Med 174(5):538–544PubMedCrossRef
20.
go back to reference Schelling G, Stoll C, Vogelmeier C et al (2000) Pulmonary function and health-related quality of life in a sample of long-term survivors of the acute respiratory distress syndrome. Intensive Care Med 26(9):1304–1311PubMedCrossRef Schelling G, Stoll C, Vogelmeier C et al (2000) Pulmonary function and health-related quality of life in a sample of long-term survivors of the acute respiratory distress syndrome. Intensive Care Med 26(9):1304–1311PubMedCrossRef
21.
go back to reference Iwashyna TJ, Ely EW, Smith DM, Langa KM (2010) Long-term cognitive impairment and functional disability among survivors of severe sepsis. JAMA 304(16):1787–1794PubMedPubMedCentralCrossRef Iwashyna TJ, Ely EW, Smith DM, Langa KM (2010) Long-term cognitive impairment and functional disability among survivors of severe sepsis. JAMA 304(16):1787–1794PubMedPubMedCentralCrossRef
22.
go back to reference Unroe M, Kahn JM, Carson SS et al (2010) One-year trajectories of care and resource utilization for recipients of prolonged mechanical ventilation: a cohort study. Ann Intern Med 153(3):167–175PubMedPubMedCentralCrossRef Unroe M, Kahn JM, Carson SS et al (2010) One-year trajectories of care and resource utilization for recipients of prolonged mechanical ventilation: a cohort study. Ann Intern Med 153(3):167–175PubMedPubMedCentralCrossRef
23.
go back to reference Needham DM, Wozniak AW, Hough CL et al (2014) Risk factors for physical impairment after acute lung injury in a national, multicenter study. Am J Respir Crit Care Med 189(10):1214–1224PubMedPubMedCentralCrossRef Needham DM, Wozniak AW, Hough CL et al (2014) Risk factors for physical impairment after acute lung injury in a national, multicenter study. Am J Respir Crit Care Med 189(10):1214–1224PubMedPubMedCentralCrossRef
24.
go back to reference Kress JP, Hall JB (2014) ICU-acquired weakness and recovery from critical illness. N Engl J Med 371(3):287–288PubMedCrossRef Kress JP, Hall JB (2014) ICU-acquired weakness and recovery from critical illness. N Engl J Med 371(3):287–288PubMedCrossRef
25.
26.
go back to reference De Jonghe B, Sharshar T, Lefaucheur JP et al (2002) Paresis acquired in the intensive care unit: a prospective multicenter study. JAMA 288(22):2859–2867PubMedCrossRef De Jonghe B, Sharshar T, Lefaucheur JP et al (2002) Paresis acquired in the intensive care unit: a prospective multicenter study. JAMA 288(22):2859–2867PubMedCrossRef
27.
go back to reference de Letter MA, Schmitz PI, Visser LH et al (2001) Risk factors for the development of polyneuropathy and myopathy in critically ill patients. Crit Care Med 29(12):2281–2286PubMedCrossRef de Letter MA, Schmitz PI, Visser LH et al (2001) Risk factors for the development of polyneuropathy and myopathy in critically ill patients. Crit Care Med 29(12):2281–2286PubMedCrossRef
28.
go back to reference Stevens RD, Dowdy DW, Michaels RK, Mendez-Tellez PA, Pronovost PJ, Needham DM (2007) Neuromuscular dysfunction acquired in critical illness: a systematic review. Intensive Care Med 33(11):1876–1891PubMedCrossRef Stevens RD, Dowdy DW, Michaels RK, Mendez-Tellez PA, Pronovost PJ, Needham DM (2007) Neuromuscular dysfunction acquired in critical illness: a systematic review. Intensive Care Med 33(11):1876–1891PubMedCrossRef
29.
go back to reference Van den Berghe G, Schoonheydt K, Becx P, Bruyninckx F, Wouters PJ (2005) Insulin therapy protects the central and peripheral nervous system of intensive care patients. Neurology 64(8):1348–1353PubMedCrossRef Van den Berghe G, Schoonheydt K, Becx P, Bruyninckx F, Wouters PJ (2005) Insulin therapy protects the central and peripheral nervous system of intensive care patients. Neurology 64(8):1348–1353PubMedCrossRef
30.
go back to reference Pandit L, Agrawal A (2006) Neuromuscular disorders in critical illness. Clin Neurol Neurosurg 108(7):621–627PubMedCrossRef Pandit L, Agrawal A (2006) Neuromuscular disorders in critical illness. Clin Neurol Neurosurg 108(7):621–627PubMedCrossRef
31.
go back to reference Latronico N, Fenzi F, Recupero D et al (1996) Critical illness myopathy and neuropathy. Lancet 347(9015):1579–1582PubMedCrossRef Latronico N, Fenzi F, Recupero D et al (1996) Critical illness myopathy and neuropathy. Lancet 347(9015):1579–1582PubMedCrossRef
32.
go back to reference Angel MJ, Bril V, Shannon P, Herridge MS (2007) Neuromuscular function in survivors of the acute respiratory distress syndrome. Can J Neurol Sci 34(4):427–432PubMedCrossRef Angel MJ, Bril V, Shannon P, Herridge MS (2007) Neuromuscular function in survivors of the acute respiratory distress syndrome. Can J Neurol Sci 34(4):427–432PubMedCrossRef
33.
go back to reference Campellone JV, Lacomis D, Kramer DJ, Van Cott AC, Giuliani MJ (1998) Acute myopathy after liver transplantation. Neurology 50(1):46–53PubMedCrossRef Campellone JV, Lacomis D, Kramer DJ, Van Cott AC, Giuliani MJ (1998) Acute myopathy after liver transplantation. Neurology 50(1):46–53PubMedCrossRef
34.
go back to reference Helliwell TR, Coakley JH, Wagenmakers AJ et al (1991) Necrotizing myopathy in critically-ill patients. J Pathol 164(4):307–314PubMedCrossRef Helliwell TR, Coakley JH, Wagenmakers AJ et al (1991) Necrotizing myopathy in critically-ill patients. J Pathol 164(4):307–314PubMedCrossRef
36.
go back to reference Wilcox ME, Brummel NE, Archer K, Ely EW, Jackson JC, Hopkins RO (2013) Cognitive dysfunction in ICU patients: risk factors, predictors, and rehabilitation interventions. Crit Care Med 41(9 Suppl 1):S81–S98PubMedCrossRef Wilcox ME, Brummel NE, Archer K, Ely EW, Jackson JC, Hopkins RO (2013) Cognitive dysfunction in ICU patients: risk factors, predictors, and rehabilitation interventions. Crit Care Med 41(9 Suppl 1):S81–S98PubMedCrossRef
37.
go back to reference Wolters AE, Slooter AJ, van der Kooi AW, van Dijk D (2013) Cognitive impairment after intensive care unit admission: a systematic review. Intensive Care Med 39(3):376–386PubMedCrossRef Wolters AE, Slooter AJ, van der Kooi AW, van Dijk D (2013) Cognitive impairment after intensive care unit admission: a systematic review. Intensive Care Med 39(3):376–386PubMedCrossRef
38.
go back to reference Hopkins RO, Weaver LK, Collingridge D, Parkinson RB, Chan KJ, Orme JF Jr (2005) Two-year cognitive, emotional, and quality-of-life outcomes in acute respiratory distress syndrome. Am J Respir Crit Care Med 171(4):340–347PubMedCrossRef Hopkins RO, Weaver LK, Collingridge D, Parkinson RB, Chan KJ, Orme JF Jr (2005) Two-year cognitive, emotional, and quality-of-life outcomes in acute respiratory distress syndrome. Am J Respir Crit Care Med 171(4):340–347PubMedCrossRef
39.
go back to reference Kapfhammer HP, Rothenhäusler HB, Krauseneck T, Stoll C, Schelling G (2004) Posttraumatic stress disorder and health-related quality of life in long-term survivors of acute respiratory distress syndrome. Am J Psychiatry 161(1):45–52PubMedCrossRef Kapfhammer HP, Rothenhäusler HB, Krauseneck T, Stoll C, Schelling G (2004) Posttraumatic stress disorder and health-related quality of life in long-term survivors of acute respiratory distress syndrome. Am J Psychiatry 161(1):45–52PubMedCrossRef
40.
go back to reference Rothenhausler HB, Ehrentraut S, Stoll C, Schelling G, Kapfhammer HP (2001) The relationship between cognitive performance and employment and health status in long-term survivors of the acute respiratory distress syndrome: results of an exploratory study. Gen Hosp Psychiatry 23(2):90–96PubMedCrossRef Rothenhausler HB, Ehrentraut S, Stoll C, Schelling G, Kapfhammer HP (2001) The relationship between cognitive performance and employment and health status in long-term survivors of the acute respiratory distress syndrome: results of an exploratory study. Gen Hosp Psychiatry 23(2):90–96PubMedCrossRef
41.
go back to reference Jackson JC, Girard TD, Gordon SM et al (2010) Long-term cognitive and psychological outcomes in the awakening and breathing controlled trial. Am J Respir Crit Care Med 182(2):183–191PubMedPubMedCentralCrossRef Jackson JC, Girard TD, Gordon SM et al (2010) Long-term cognitive and psychological outcomes in the awakening and breathing controlled trial. Am J Respir Crit Care Med 182(2):183–191PubMedPubMedCentralCrossRef
42.
go back to reference Needham DM, Dinglas VD, Bienvenu OJ et al (2013) One year outcomes in patients with acute lung injury randomised to initial trophic or full enteral feeding: prospective follow-up of EDEN randomised trial. BMJ 346:f1532PubMedPubMedCentralCrossRef Needham DM, Dinglas VD, Bienvenu OJ et al (2013) One year outcomes in patients with acute lung injury randomised to initial trophic or full enteral feeding: prospective follow-up of EDEN randomised trial. BMJ 346:f1532PubMedPubMedCentralCrossRef
43.
go back to reference Needham DM, Dinglas VD, Morris PE et al (2013) Physical and cognitive performance of patients with acute lung injury 1 year after initial trophic versus full enteral feeding. EDEN trial follow-up. Am J Respir Crit Care Med 188(5):567–576PubMedPubMedCentralCrossRef Needham DM, Dinglas VD, Morris PE et al (2013) Physical and cognitive performance of patients with acute lung injury 1 year after initial trophic versus full enteral feeding. EDEN trial follow-up. Am J Respir Crit Care Med 188(5):567–576PubMedPubMedCentralCrossRef
44.
45.
go back to reference Adhikari NK, McAndrews MP, Tansey CM et al (2009) Self-reported symptoms of depression and memory dysfunction in survivors of ARDS. Chest 135(3):678–687PubMedCrossRef Adhikari NK, McAndrews MP, Tansey CM et al (2009) Self-reported symptoms of depression and memory dysfunction in survivors of ARDS. Chest 135(3):678–687PubMedCrossRef
46.
go back to reference Adhikari NK, Tansey CM, McAndrews MP et al (2011) Self-reported depressive symptoms and memory complaints in survivors five years after ARDS. Chest 140(6):1484–1493PubMedCrossRef Adhikari NK, Tansey CM, McAndrews MP et al (2011) Self-reported depressive symptoms and memory complaints in survivors five years after ARDS. Chest 140(6):1484–1493PubMedCrossRef
47.
go back to reference Pfoh ER, Chan KS, Dinglas VD et al (2015) Cognitive screening among acute respiratory failure survivors: a cross-sectional evaluation of the mini-mental state examination. Crit Care 19:220PubMedPubMedCentralCrossRef Pfoh ER, Chan KS, Dinglas VD et al (2015) Cognitive screening among acute respiratory failure survivors: a cross-sectional evaluation of the mini-mental state examination. Crit Care 19:220PubMedPubMedCentralCrossRef
48.
go back to reference Woon FL, Dunn CB, Hopkins RO (2012) Predicting cognitive sequelae in survivors of critical illness with cognitive screening tests. Am J Respir Crit Care Med 186(4):333–340PubMedCrossRef Woon FL, Dunn CB, Hopkins RO (2012) Predicting cognitive sequelae in survivors of critical illness with cognitive screening tests. Am J Respir Crit Care Med 186(4):333–340PubMedCrossRef
49.
go back to reference Zhao J, Yao L, Wang C, Sun Y, Sun Z (2015) The effects of cognitive intervention on cognitive impairments after intensive care unit admission. Neuropsychol Rehabil 27:1–17 Zhao J, Yao L, Wang C, Sun Y, Sun Z (2015) The effects of cognitive intervention on cognitive impairments after intensive care unit admission. Neuropsychol Rehabil 27:1–17
50.
go back to reference Mikkelsen ME, Christie JD, Lanken PN et al (2012) The adult respiratory distress syndrome cognitive outcomes study: long-term neuropsychological function in survivors of acute lung injury. Am J Respir Crit Care Med 185(12):1307–1315PubMedPubMedCentralCrossRef Mikkelsen ME, Christie JD, Lanken PN et al (2012) The adult respiratory distress syndrome cognitive outcomes study: long-term neuropsychological function in survivors of acute lung injury. Am J Respir Crit Care Med 185(12):1307–1315PubMedPubMedCentralCrossRef
51.
go back to reference Bigler ED, Blatter DD, Anderson CV et al (1997) Hippocampal volume in normal aging and traumatic brain injury. AJNR Am J Neuroradiol 18(1):11–23PubMed Bigler ED, Blatter DD, Anderson CV et al (1997) Hippocampal volume in normal aging and traumatic brain injury. AJNR Am J Neuroradiol 18(1):11–23PubMed
52.
go back to reference Hopkins RO, Suchyta MR, Snow GL, Jephson A, Weaver LK, Orme JF (2010) Blood glucose dysregulation and cognitive outcome in ARDS survivors. Brain Inj 24(12):1478–1484PubMedCrossRef Hopkins RO, Suchyta MR, Snow GL, Jephson A, Weaver LK, Orme JF (2010) Blood glucose dysregulation and cognitive outcome in ARDS survivors. Brain Inj 24(12):1478–1484PubMedCrossRef
53.
go back to reference Mikkelsen ME LP, Biester R, Gallop R, Bellamy S, Localio AR, Hopkins RO, Angus DC, Christie JD (2008) Conservative fluid strategy is associated with neurocognitive deficits in survivors of acute lung injury. Am J Respir Crit Care Med 177:A819 Mikkelsen ME LP, Biester R, Gallop R, Bellamy S, Localio AR, Hopkins RO, Angus DC, Christie JD (2008) Conservative fluid strategy is associated with neurocognitive deficits in survivors of acute lung injury. Am J Respir Crit Care Med 177:A819
54.
go back to reference Needham DM, Colantuoni E, Dinglas VD et al (2016) Rosuvastatin versus placebo for delirium in intensive care and subsequent cognitive impairment in patients with sepsis-associated acute respiratory distress syndrome: an ancillary study to a randomised controlled trial. Lancet Respir Med. doi:10.1016/S2213-2600(16)00005-9 Needham DM, Colantuoni E, Dinglas VD et al (2016) Rosuvastatin versus placebo for delirium in intensive care and subsequent cognitive impairment in patients with sepsis-associated acute respiratory distress syndrome: an ancillary study to a randomised controlled trial. Lancet Respir Med. doi:10.​1016/​S2213-2600(16)00005-9
55.
go back to reference Bienvenu OJ, Neufeld KJ (2011) Post-traumatic stress disorder in medical settings: focus on the critically ill. Curr Psychiatry Rep 13(1):3–9PubMedCrossRef Bienvenu OJ, Neufeld KJ (2011) Post-traumatic stress disorder in medical settings: focus on the critically ill. Curr Psychiatry Rep 13(1):3–9PubMedCrossRef
56.
go back to reference Bienvenu OJ (2014) Depressive mood states following critical illness. In: Stevens RD, Hart N, Herridge M (eds) The legacy of critical illness—a textbook of post-ICU medicine. Oxford University Press, New York, pp 216–231 Bienvenu OJ (2014) Depressive mood states following critical illness. In: Stevens RD, Hart N, Herridge M (eds) The legacy of critical illness—a textbook of post-ICU medicine. Oxford University Press, New York, pp 216–231
57.
go back to reference Needham DM, Davidson J, Cohen H et al (2012) Improving long-term outcomes after discharge from intensive care unit: report from a stakeholders’ conference. Crit Care Med 40(2):502–509PubMedCrossRef Needham DM, Davidson J, Cohen H et al (2012) Improving long-term outcomes after discharge from intensive care unit: report from a stakeholders’ conference. Crit Care Med 40(2):502–509PubMedCrossRef
58.
go back to reference Davidson JE, Jones C, Bienvenu OJ (2012) Family response to critical illness: post-intensive care syndrome—family. Crit Care Med 40(2):618–624PubMedCrossRef Davidson JE, Jones C, Bienvenu OJ (2012) Family response to critical illness: post-intensive care syndrome—family. Crit Care Med 40(2):618–624PubMedCrossRef
59.
go back to reference Davydow DS, Gifford JM, Desai SV, Bienvenu OJ, Needham DM (2009) Depression in general intensive care unit survivors: a systematic review. Intensive Care Med 35(5):796–809PubMedCrossRef Davydow DS, Gifford JM, Desai SV, Bienvenu OJ, Needham DM (2009) Depression in general intensive care unit survivors: a systematic review. Intensive Care Med 35(5):796–809PubMedCrossRef
60.
go back to reference Davydow DS, Gifford JM, Desai SV, Needham DM, Bienvenu OJ (2008) Posttraumatic stress disorder in general intensive care unit survivors: a systematic review. Gen Hosp Psychiatry 30(5):421–434PubMedPubMedCentralCrossRef Davydow DS, Gifford JM, Desai SV, Needham DM, Bienvenu OJ (2008) Posttraumatic stress disorder in general intensive care unit survivors: a systematic review. Gen Hosp Psychiatry 30(5):421–434PubMedPubMedCentralCrossRef
61.
go back to reference Parker AM, Sricharoenchai T, Raparla S, Schneck KW, Bienvenu OJ, Needham DM (2015) Posttraumatic stress disorder in critical illness survivors: a metaanalysis. Crit Care Med 43(5):1121–1129PubMedCrossRef Parker AM, Sricharoenchai T, Raparla S, Schneck KW, Bienvenu OJ, Needham DM (2015) Posttraumatic stress disorder in critical illness survivors: a metaanalysis. Crit Care Med 43(5):1121–1129PubMedCrossRef
62.
go back to reference Davydow DS, Desai SV, Needham DM, Bienvenu OJ (2008) Psychiatric morbidity in survivors of the acute respiratory distress syndrome: a systematic review. Psychosom Med 70(4):512–519PubMedCrossRef Davydow DS, Desai SV, Needham DM, Bienvenu OJ (2008) Psychiatric morbidity in survivors of the acute respiratory distress syndrome: a systematic review. Psychosom Med 70(4):512–519PubMedCrossRef
63.
go back to reference Herridge MS, Angus DC (2005) Acute lung injury: affecting many lives. New Engl J Med 353(16):1736–1738PubMedCrossRef Herridge MS, Angus DC (2005) Acute lung injury: affecting many lives. New Engl J Med 353(16):1736–1738PubMedCrossRef
64.
go back to reference Schelling G, Stoll C, Haller M et al (1998) Health-related quality of life and posttraumatic stress disorder in survivors of the acute respiratory distress syndrome. Crit Care Med 26(4):651–659PubMedCrossRef Schelling G, Stoll C, Haller M et al (1998) Health-related quality of life and posttraumatic stress disorder in survivors of the acute respiratory distress syndrome. Crit Care Med 26(4):651–659PubMedCrossRef
65.
go back to reference Deja M, Denke C, Weber-Carstens S et al (2006) Social support during intensive care unit stay might improve mental impairment and consequently health-related quality of life in survivors of severe acute respiratory distress syndrome. Crit Care 10(5):R147PubMedPubMedCentralCrossRef Deja M, Denke C, Weber-Carstens S et al (2006) Social support during intensive care unit stay might improve mental impairment and consequently health-related quality of life in survivors of severe acute respiratory distress syndrome. Crit Care 10(5):R147PubMedPubMedCentralCrossRef
66.
go back to reference Hopkins RO, Weaver LK, Chan KJ, Orme JF Jr (2004) Quality of life, emotional, and cognitive function following acute respiratory distress syndrome. J Int Neuropsychol Soc 10(7):1005–1017PubMed Hopkins RO, Weaver LK, Chan KJ, Orme JF Jr (2004) Quality of life, emotional, and cognitive function following acute respiratory distress syndrome. J Int Neuropsychol Soc 10(7):1005–1017PubMed
67.
go back to reference Schelling G, Kapfhammer HP (2013) Surviving the ICU does not mean that the war is over. Chest 144(1):1–3PubMedCrossRef Schelling G, Kapfhammer HP (2013) Surviving the ICU does not mean that the war is over. Chest 144(1):1–3PubMedCrossRef
68.
go back to reference Christie JD, Biester RC, Taichman DB et al (2006) Formation and validation of a telephone battery to assess cognitive function in acute respiratory distress syndrome survivors. J Crit Care 21(2):125–132PubMedCrossRef Christie JD, Biester RC, Taichman DB et al (2006) Formation and validation of a telephone battery to assess cognitive function in acute respiratory distress syndrome survivors. J Crit Care 21(2):125–132PubMedCrossRef
70.
go back to reference Shaw RJ, Harvey JE, Nelson KL, Gunary R, Kruk H, Steiner H (2001) Linguistic analysis to assess medically related posttraumatic stress symptoms. Psychosomatics 42(1):35–40PubMedCrossRef Shaw RJ, Harvey JE, Nelson KL, Gunary R, Kruk H, Steiner H (2001) Linguistic analysis to assess medically related posttraumatic stress symptoms. Psychosomatics 42(1):35–40PubMedCrossRef
71.
go back to reference Stoll C, Kapfhammer HP, Rothenhausler HB et al (1999) Sensitivity and specificity of a screening test to document traumatic experiences and to diagnose post-traumatic stress disorder in ARDS patients after intensive care treatment. Intensive Care Med 25(7):697–704PubMedCrossRef Stoll C, Kapfhammer HP, Rothenhausler HB et al (1999) Sensitivity and specificity of a screening test to document traumatic experiences and to diagnose post-traumatic stress disorder in ARDS patients after intensive care treatment. Intensive Care Med 25(7):697–704PubMedCrossRef
72.
go back to reference Bienvenu OJ, Colantuoni E, Mendez-Tellez PA et al (2012) Depressive symptoms and impaired physical function after acute lung injury: a 2-year longitudinal study. Am J Respir Crit Care Med 185(5):517–524PubMedPubMedCentralCrossRef Bienvenu OJ, Colantuoni E, Mendez-Tellez PA et al (2012) Depressive symptoms and impaired physical function after acute lung injury: a 2-year longitudinal study. Am J Respir Crit Care Med 185(5):517–524PubMedPubMedCentralCrossRef
73.
go back to reference Bienvenu OJ, Colantuoni E, Mendez-Tellez PA et al (2015) Cooccurrence of and remission from general anxiety, depression, and posttraumatic stress disorder symptoms after acute lung injury: a 2-year longitudinal study. Crit Care Med 43(3):642–653PubMedPubMedCentralCrossRef Bienvenu OJ, Colantuoni E, Mendez-Tellez PA et al (2015) Cooccurrence of and remission from general anxiety, depression, and posttraumatic stress disorder symptoms after acute lung injury: a 2-year longitudinal study. Crit Care Med 43(3):642–653PubMedPubMedCentralCrossRef
74.
go back to reference Bienvenu OJ, Gellar J, Althouse BM et al (2013) Post-traumatic stress disorder symptoms after acute lung injury: a 2-year prospective longitudinal study. Psychol Med 43(12):2657–2671PubMedCrossRef Bienvenu OJ, Gellar J, Althouse BM et al (2013) Post-traumatic stress disorder symptoms after acute lung injury: a 2-year prospective longitudinal study. Psychol Med 43(12):2657–2671PubMedCrossRef
75.
go back to reference Bienvenu OJ, Williams JB, Yang A, Hopkins RO, Needham DM (2013) Posttraumatic stress disorder in survivors of acute lung injury: evaluating the impact of event scale-revised. Chest 144(1):24–31PubMedPubMedCentralCrossRef Bienvenu OJ, Williams JB, Yang A, Hopkins RO, Needham DM (2013) Posttraumatic stress disorder in survivors of acute lung injury: evaluating the impact of event scale-revised. Chest 144(1):24–31PubMedPubMedCentralCrossRef
76.
go back to reference Dowdy DW, Bienvenu OJ, Dinglas VD et al (2009) Are intensive care factors associated with depressive symptoms 6 months after acute lung injury? Crit Care Med 37(5):1702–1707PubMedPubMedCentralCrossRef Dowdy DW, Bienvenu OJ, Dinglas VD et al (2009) Are intensive care factors associated with depressive symptoms 6 months after acute lung injury? Crit Care Med 37(5):1702–1707PubMedPubMedCentralCrossRef
77.
go back to reference Dowdy DW, Dinglas V, Mendez-Tellez PA et al (2008) Intensive care unit hypoglycemia predicts depression during early recovery from acute lung injury. Crit Care Med 36(10):2726–2733PubMedPubMedCentralCrossRef Dowdy DW, Dinglas V, Mendez-Tellez PA et al (2008) Intensive care unit hypoglycemia predicts depression during early recovery from acute lung injury. Crit Care Med 36(10):2726–2733PubMedPubMedCentralCrossRef
78.
go back to reference Hopkins RO, Key CW, Suchyta MR, Weaver LK, Orme JF Jr (2010) Risk factors for depression and anxiety in survivors of acute respiratory distress syndrome. Gen Hosp Psychiatry 32(2):147–155PubMedCrossRef Hopkins RO, Key CW, Suchyta MR, Weaver LK, Orme JF Jr (2010) Risk factors for depression and anxiety in survivors of acute respiratory distress syndrome. Gen Hosp Psychiatry 32(2):147–155PubMedCrossRef
79.
go back to reference Huang M, Parker AM, Bienvenu OJ et al (2016) Psychiatric symptoms in acute respiratory distress syndrome survivors: a 1-year national multicenter study. Crit Care Med (in press) Huang M, Parker AM, Bienvenu OJ et al (2016) Psychiatric symptoms in acute respiratory distress syndrome survivors: a 1-year national multicenter study. Crit Care Med (in press)
80.
go back to reference Jutte JE, Needham DM, Pfoh ER, Bienvenu OJ (2015) Psychometric evaluation of the hospital anxiety and depression scale 3 months after acute lung injury. J Crit Care 30(4):793–798PubMedCrossRef Jutte JE, Needham DM, Pfoh ER, Bienvenu OJ (2015) Psychometric evaluation of the hospital anxiety and depression scale 3 months after acute lung injury. J Crit Care 30(4):793–798PubMedCrossRef
81.
go back to reference Stevenson JE, Colantuoni E, Bienvenu OJ et al (2013) General anxiety symptoms after acute lung injury: predictors and correlates. J Psychosom Res 75(3):287–293PubMedPubMedCentralCrossRef Stevenson JE, Colantuoni E, Bienvenu OJ et al (2013) General anxiety symptoms after acute lung injury: predictors and correlates. J Psychosom Res 75(3):287–293PubMedPubMedCentralCrossRef
82.
83.
84.
go back to reference Garrouste-Orgeas M, Coquet I, Périer A et al (2012) Impact of an intensive care unit diary on psychological distress in patients and relatives. Crit Care Med 40:2033–2040PubMedCrossRef Garrouste-Orgeas M, Coquet I, Périer A et al (2012) Impact of an intensive care unit diary on psychological distress in patients and relatives. Crit Care Med 40:2033–2040PubMedCrossRef
85.
go back to reference Jones C, Bäckman C, Capuzzo M et al (2010) Intensive care diaries reduce new-onset post-traumatic stress disorder following critical illness: a randomised, controlled trial. Crit Care 14:R168PubMedPubMedCentralCrossRef Jones C, Bäckman C, Capuzzo M et al (2010) Intensive care diaries reduce new-onset post-traumatic stress disorder following critical illness: a randomised, controlled trial. Crit Care 14:R168PubMedPubMedCentralCrossRef
86.
go back to reference Aitken LM, Rattray A, Hull A, Kenardy JA, Le Brocque R, Ullman AJ (2013) The use of diaries in psychological recovery from intensive care. Crit Care 17:253PubMedPubMedCentralCrossRef Aitken LM, Rattray A, Hull A, Kenardy JA, Le Brocque R, Ullman AJ (2013) The use of diaries in psychological recovery from intensive care. Crit Care 17:253PubMedPubMedCentralCrossRef
87.
go back to reference Ullman AJ, Aitken LM, Rattray J et al (2014) Diaries for recovery from critical illness. Cochrane Database Syst Rev 12:CD010468 Ullman AJ, Aitken LM, Rattray J et al (2014) Diaries for recovery from critical illness. Cochrane Database Syst Rev 12:CD010468
88.
go back to reference Cox CE, Porter LS, Hough CL et al (2012) Development and preliminary evaluation of a telephone-based coping skills training intervention for survivors of acute lung injury and their informal caregivers. Intensive Care Med 38(8):1289–1297PubMedPubMedCentralCrossRef Cox CE, Porter LS, Hough CL et al (2012) Development and preliminary evaluation of a telephone-based coping skills training intervention for survivors of acute lung injury and their informal caregivers. Intensive Care Med 38(8):1289–1297PubMedPubMedCentralCrossRef
89.
go back to reference Peris A, Bonizzoli M, Iozzelli D et al (2011) Early intra-intensive care unit psychological intervention promotes recovery from post traumatic stress disorders, anxiety and depression symptoms in critically ill patients. Crit Care 15(1):R41PubMedPubMedCentralCrossRef Peris A, Bonizzoli M, Iozzelli D et al (2011) Early intra-intensive care unit psychological intervention promotes recovery from post traumatic stress disorders, anxiety and depression symptoms in critically ill patients. Crit Care 15(1):R41PubMedPubMedCentralCrossRef
90.
go back to reference Girard TD, Jackson JC, Pandharipande PP et al (2010) Delirium as a predictor of long-term cognitive impairment in survivors of critical illness. Crit Care Med 38(7):1513–1520PubMedPubMedCentralCrossRef Girard TD, Jackson JC, Pandharipande PP et al (2010) Delirium as a predictor of long-term cognitive impairment in survivors of critical illness. Crit Care Med 38(7):1513–1520PubMedPubMedCentralCrossRef
91.
go back to reference Jackson JC, Pandharipande PP, Girard TD et al (2014) Depression, post-traumatic stress disorder, and functional disability in survivors of critical illness in the BRAIN-ICU study: a longitudinal cohort study. Lancet Respir Med 2(5):369–379PubMedPubMedCentralCrossRef Jackson JC, Pandharipande PP, Girard TD et al (2014) Depression, post-traumatic stress disorder, and functional disability in survivors of critical illness in the BRAIN-ICU study: a longitudinal cohort study. Lancet Respir Med 2(5):369–379PubMedPubMedCentralCrossRef
92.
go back to reference Devlin JW, Garpestad E, Hill NS (2010) Neuromuscular blockers and ARDS. N Engl J Med 363(26):2562 (author reply 2563–2564)PubMedCrossRef Devlin JW, Garpestad E, Hill NS (2010) Neuromuscular blockers and ARDS. N Engl J Med 363(26):2562 (author reply 2563–2564)PubMedCrossRef
93.
go back to reference Girard TD, Pandharipande PP, Carson SS et al (2010) Feasibility, efficacy, and safety of antipsychotics for intensive care unit delirium: the MIND randomized, placebo-controlled trial. Crit Care Med 38(2):428–437PubMedPubMedCentralCrossRef Girard TD, Pandharipande PP, Carson SS et al (2010) Feasibility, efficacy, and safety of antipsychotics for intensive care unit delirium: the MIND randomized, placebo-controlled trial. Crit Care Med 38(2):428–437PubMedPubMedCentralCrossRef
94.
go back to reference Girard TD, Kress JP, Fuchs BD et al (2008) Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (awakening and breathing controlled trial): a randomised controlled trial. Lancet 371(9607):126–134PubMedCrossRef Girard TD, Kress JP, Fuchs BD et al (2008) Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (awakening and breathing controlled trial): a randomised controlled trial. Lancet 371(9607):126–134PubMedCrossRef
95.
go back to reference Kress JP, Pohlman AS, O’Connor MF, Hall JB (2000) Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation. N Engl J Med 342(20):1471–1477PubMedCrossRef Kress JP, Pohlman AS, O’Connor MF, Hall JB (2000) Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation. N Engl J Med 342(20):1471–1477PubMedCrossRef
96.
go back to reference Strom T, Martinussen T, Toft P (2010) A protocol of no sedation for critically ill patients receiving mechanical ventilation: a randomised trial. Lancet 375(9713):475–480PubMedCrossRef Strom T, Martinussen T, Toft P (2010) A protocol of no sedation for critically ill patients receiving mechanical ventilation: a randomised trial. Lancet 375(9713):475–480PubMedCrossRef
97.
go back to reference Strawn JR, Geracioti TD Jr (2008) Noradrenergic dysfunction and the psychopharmacology of posttraumatic stress disorder. Depress Anxiety 25(3):260–271PubMedCrossRef Strawn JR, Geracioti TD Jr (2008) Noradrenergic dysfunction and the psychopharmacology of posttraumatic stress disorder. Depress Anxiety 25(3):260–271PubMedCrossRef
98.
go back to reference Krauseneck T, Padberg F, Roozendaal B et al (2010) A beta-adrenergic antagonist reduces traumatic memories and PTSD symptoms in female but not in male patients after cardiac surgery. Psychol Med 40(5):861–869PubMedCrossRef Krauseneck T, Padberg F, Roozendaal B et al (2010) A beta-adrenergic antagonist reduces traumatic memories and PTSD symptoms in female but not in male patients after cardiac surgery. Psychol Med 40(5):861–869PubMedCrossRef
99.
go back to reference Wei X, Day AG, Ouellette-Kuntz H, Heyland DK (2015) The association between nutritional adequacy and long-term outcomes in critically ill patients requiring prolonged mechanical ventilation: a multicenter cohort study. Crit Care Med 43(8):1569–1579PubMedCrossRef Wei X, Day AG, Ouellette-Kuntz H, Heyland DK (2015) The association between nutritional adequacy and long-term outcomes in critically ill patients requiring prolonged mechanical ventilation: a multicenter cohort study. Crit Care Med 43(8):1569–1579PubMedCrossRef
100.
go back to reference Rice TW, Wheeler AP, Thompson BT et al (2012) Initial trophic vs full enteral feeding in patients with acute lung injury: the EDEN randomized trial. JAMA 307(8):795–803PubMedCrossRef Rice TW, Wheeler AP, Thompson BT et al (2012) Initial trophic vs full enteral feeding in patients with acute lung injury: the EDEN randomized trial. JAMA 307(8):795–803PubMedCrossRef
101.
go back to reference Rice TW, Mogan S, Hays MA, Bernard GR, Jensen GL, Wheeler AP (2011) Randomized trial of initial trophic versus full-energy enteral nutrition in mechanically ventilated patients with acute respiratory failure. Crit Care Med 39(5):967–974PubMedPubMedCentralCrossRef Rice TW, Mogan S, Hays MA, Bernard GR, Jensen GL, Wheeler AP (2011) Randomized trial of initial trophic versus full-energy enteral nutrition in mechanically ventilated patients with acute respiratory failure. Crit Care Med 39(5):967–974PubMedPubMedCentralCrossRef
102.
go back to reference Brummel NE, Girard TD, Ely EW et al (2014) Feasibility and safety of early combined cognitive and physical therapy for critically ill medical and surgical patients: the activity and cognitive therapy in ICU (ACT-ICU) trial. Intensive Care Med 40(3):370–379PubMedPubMedCentralCrossRef Brummel NE, Girard TD, Ely EW et al (2014) Feasibility and safety of early combined cognitive and physical therapy for critically ill medical and surgical patients: the activity and cognitive therapy in ICU (ACT-ICU) trial. Intensive Care Med 40(3):370–379PubMedPubMedCentralCrossRef
103.
go back to reference Heyland DK, Stapleton RD, Mourtzakis M et al (2015) Combining nutrition and exercise to optimize survival and recovery from critical illness: conceptual and methodological issues. Clin Nutr. doi:10.1016/j.clnu.2015.07.003 Heyland DK, Stapleton RD, Mourtzakis M et al (2015) Combining nutrition and exercise to optimize survival and recovery from critical illness: conceptual and methodological issues. Clin Nutr. doi:10.​1016/​j.​clnu.​2015.​07.​003
104.
go back to reference Wischmeyer PE, San-Millan I (2015) Winning the war against ICU-acquired weakness: new innovations in nutrition and exercise physiology. Crit Care 19(Suppl 3):S6PubMedPubMedCentral Wischmeyer PE, San-Millan I (2015) Winning the war against ICU-acquired weakness: new innovations in nutrition and exercise physiology. Crit Care 19(Suppl 3):S6PubMedPubMedCentral
105.
go back to reference Papazian L, Forel JM, Gacouin A et al (2010) Neuromuscular blockers in early acute respiratory distress syndrome. N Engl J Med 363(12):1107–1116PubMedCrossRef Papazian L, Forel JM, Gacouin A et al (2010) Neuromuscular blockers in early acute respiratory distress syndrome. N Engl J Med 363(12):1107–1116PubMedCrossRef
106.
go back to reference Bice T, Cox CE, Carson SS (2013) Cost and health care utilization in ARDS—different from other critical illness? Semin Respir Crit Care Med 34(4):529–536PubMedPubMedCentralCrossRef Bice T, Cox CE, Carson SS (2013) Cost and health care utilization in ARDS—different from other critical illness? Semin Respir Crit Care Med 34(4):529–536PubMedPubMedCentralCrossRef
107.
go back to reference The Veterans Affairs Total Parenteral Nutrition Cooperative Study Group (1991) Perioperative total parenteral nutrition in surgical patients. N Engl J Med 325(8):525–532CrossRef The Veterans Affairs Total Parenteral Nutrition Cooperative Study Group (1991) Perioperative total parenteral nutrition in surgical patients. N Engl J Med 325(8):525–532CrossRef
108.
go back to reference Hamel MB, Phillips RS, Davis RB et al (2000) Outcomes and cost-effectiveness of ventilator support and aggressive care for patients with acute respiratory failure due to pneumonia or acute respiratory distress syndrome. Am J Med 109(8):614–620PubMedCrossRef Hamel MB, Phillips RS, Davis RB et al (2000) Outcomes and cost-effectiveness of ventilator support and aggressive care for patients with acute respiratory failure due to pneumonia or acute respiratory distress syndrome. Am J Med 109(8):614–620PubMedCrossRef
109.
go back to reference Sznajder M, Aegerter P, Launois R, Merliere Y, Guidet B (2001) CubRea. A cost-effectiveness analysis of stays in intensive care units. Intensive Care Med 27(1):146–153PubMedCrossRef Sznajder M, Aegerter P, Launois R, Merliere Y, Guidet B (2001) CubRea. A cost-effectiveness analysis of stays in intensive care units. Intensive Care Med 27(1):146–153PubMedCrossRef
110.
go back to reference Talmor D, Greenberg D, Howell MD, Lisbon A, Novack V, Shapiro N (2008) The costs and cost-effectiveness of an integrated sepsis treatment protocol. Crit Care Med 36(4):1168–1174PubMedCrossRef Talmor D, Greenberg D, Howell MD, Lisbon A, Novack V, Shapiro N (2008) The costs and cost-effectiveness of an integrated sepsis treatment protocol. Crit Care Med 36(4):1168–1174PubMedCrossRef
111.
go back to reference Prescott HC, Langa KM, Liu V, Escobar GJ, Iwashyna TJ (2014) Increased 1-year healthcare use in survivors of severe sepsis. Am J Respir Crit Care Med 190(1):62–69PubMedPubMedCentralCrossRef Prescott HC, Langa KM, Liu V, Escobar GJ, Iwashyna TJ (2014) Increased 1-year healthcare use in survivors of severe sepsis. Am J Respir Crit Care Med 190(1):62–69PubMedPubMedCentralCrossRef
112.
go back to reference Needham DM (2008) Mobilizing patients in the intensive care unit: improving neuromuscular weakness and physical function. JAMA 300(14):1685–1690PubMedCrossRef Needham DM (2008) Mobilizing patients in the intensive care unit: improving neuromuscular weakness and physical function. JAMA 300(14):1685–1690PubMedCrossRef
113.
go back to reference Bailey P, Thomsen GE, Spuhler VJ et al (2007) Early activity is feasible and safe in respiratory failure patients. Crit Care Med 35(1):139–145PubMedCrossRef Bailey P, Thomsen GE, Spuhler VJ et al (2007) Early activity is feasible and safe in respiratory failure patients. Crit Care Med 35(1):139–145PubMedCrossRef
114.
go back to reference Morris PE (2007) Moving our critically ill patients: mobility barriers and benefits. Crit Care Clin 23(1):1–20PubMedCrossRef Morris PE (2007) Moving our critically ill patients: mobility barriers and benefits. Crit Care Clin 23(1):1–20PubMedCrossRef
115.
go back to reference Morris PE, Griffin L, Berry M et al (2011) Receiving early mobility during an intensive care unit admission is a predictor of improved outcomes in acute respiratory failure. Am J Med Sci 341(5):373–377PubMedPubMedCentralCrossRef Morris PE, Griffin L, Berry M et al (2011) Receiving early mobility during an intensive care unit admission is a predictor of improved outcomes in acute respiratory failure. Am J Med Sci 341(5):373–377PubMedPubMedCentralCrossRef
116.
go back to reference Schweickert WD, Pohlman MC, Pohlman AS et al (2009) Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial. Lancet 373(9678):1874–1882PubMedCrossRef Schweickert WD, Pohlman MC, Pohlman AS et al (2009) Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial. Lancet 373(9678):1874–1882PubMedCrossRef
117.
go back to reference Burtin C, Clerckx B, Robbeets C et al (2009) Early exercise in critically ill patients enhances short-term functional recovery. Crit Care Med 37(9):2499–2505PubMedCrossRef Burtin C, Clerckx B, Robbeets C et al (2009) Early exercise in critically ill patients enhances short-term functional recovery. Crit Care Med 37(9):2499–2505PubMedCrossRef
118.
go back to reference Moss M, Nordon-Craft A, Malone D et al (2015) A randomized trial of an intensive physical therapy program for acute respiratory failure patients. Am J Respir Crit Care Med. doi:10.1164/rccm.201505-1039OC Moss M, Nordon-Craft A, Malone D et al (2015) A randomized trial of an intensive physical therapy program for acute respiratory failure patients. Am J Respir Crit Care Med. doi:10.​1164/​rccm.​201505-1039OC
119.
go back to reference Jones C, Skirrow P, Griffiths RD et al (2003) Rehabilitation after critical illness: a randomized, controlled trial. Crit Care Med 31(10):2456–2461PubMedCrossRef Jones C, Skirrow P, Griffiths RD et al (2003) Rehabilitation after critical illness: a randomized, controlled trial. Crit Care Med 31(10):2456–2461PubMedCrossRef
120.
go back to reference Cuthbertson BH, Rattray J, Campbell MK et al (2009) The PRaCTICaL study of nurse led, intensive care follow-up programmes for improving long term outcomes from critical illness: a pragmatic randomised controlled trial. BMJ 339:b3723PubMedPubMedCentralCrossRef Cuthbertson BH, Rattray J, Campbell MK et al (2009) The PRaCTICaL study of nurse led, intensive care follow-up programmes for improving long term outcomes from critical illness: a pragmatic randomised controlled trial. BMJ 339:b3723PubMedPubMedCentralCrossRef
121.
go back to reference Elliott D, McKinley S, Alison J et al (2011) Health-related quality of life and physical recovery after a critical illness: a multi-centre randomised controlled trial of a home-based physical rehabilitation program. Crit Care 15(3):R142PubMedPubMedCentralCrossRef Elliott D, McKinley S, Alison J et al (2011) Health-related quality of life and physical recovery after a critical illness: a multi-centre randomised controlled trial of a home-based physical rehabilitation program. Crit Care 15(3):R142PubMedPubMedCentralCrossRef
122.
go back to reference Denehy L, Skinner EH, Edbrooke L et al (2013) Exercise rehabilitation for patients with critical illness: a randomized controlled trial with 12 months of follow-up. Crit Care 17(4):R156PubMedPubMedCentralCrossRef Denehy L, Skinner EH, Edbrooke L et al (2013) Exercise rehabilitation for patients with critical illness: a randomized controlled trial with 12 months of follow-up. Crit Care 17(4):R156PubMedPubMedCentralCrossRef
123.
go back to reference Walsh TS, Salisbury LG, Merriweather JL et al (2015) Increased hospital-based physical rehabilitation and information provision after intensive care unit discharge: the recover randomized clinical trial. JAMA Intern Med 175(6):901–910PubMedCrossRef Walsh TS, Salisbury LG, Merriweather JL et al (2015) Increased hospital-based physical rehabilitation and information provision after intensive care unit discharge: the recover randomized clinical trial. JAMA Intern Med 175(6):901–910PubMedCrossRef
124.
go back to reference Harrold ME, Salisbury LG, Webb SA, Allison GT, Australia and Scotland ICU Physiotherapy Collaboration (2015) Australia, Scotland ICUPC. Early mobilisation in intensive care units in Australia and Scotland: a prospective, observational cohort study examining mobilisation practises and barriers. Crit Care 19:336PubMedPubMedCentralCrossRef Harrold ME, Salisbury LG, Webb SA, Allison GT, Australia and Scotland ICU Physiotherapy Collaboration (2015) Australia, Scotland ICUPC. Early mobilisation in intensive care units in Australia and Scotland: a prospective, observational cohort study examining mobilisation practises and barriers. Crit Care 19:336PubMedPubMedCentralCrossRef
125.
go back to reference Puntillo K, Nelson JE, Weissman D et al (2014) Palliative care in the ICU: relief of pain, dyspnea, and thirst—a report from the IPAL-ICU Advisory Board. Intensive Care Med 40(2):235–248PubMedCrossRef Puntillo K, Nelson JE, Weissman D et al (2014) Palliative care in the ICU: relief of pain, dyspnea, and thirst—a report from the IPAL-ICU Advisory Board. Intensive Care Med 40(2):235–248PubMedCrossRef
126.
go back to reference Azoulay E, Citerio G, Bakker J et al (2014) Year in review in Intensive Care Medicine 2013: II. Sedation, invasive and noninvasive ventilation, airways, ARDS, ECMO, family satisfaction, end-of-life care, organ donation, informed consent, safety, hematological issues in critically ill patients. Intensive Care Med 40(3):305–319PubMedCrossRef Azoulay E, Citerio G, Bakker J et al (2014) Year in review in Intensive Care Medicine 2013: II. Sedation, invasive and noninvasive ventilation, airways, ARDS, ECMO, family satisfaction, end-of-life care, organ donation, informed consent, safety, hematological issues in critically ill patients. Intensive Care Med 40(3):305–319PubMedCrossRef
127.
go back to reference Jabre P, Tazarourte K, Azoulay E et al (2014) Offering the opportunity for family to be present during cardiopulmonary resuscitation: 1-year assessment. Intensive Care Med 40(7):981–987PubMedCrossRef Jabre P, Tazarourte K, Azoulay E et al (2014) Offering the opportunity for family to be present during cardiopulmonary resuscitation: 1-year assessment. Intensive Care Med 40(7):981–987PubMedCrossRef
128.
go back to reference Verceles AC, Corwin DS, Afshar M et al (2014) Half of the family members of critically ill patients experience excessive daytime sleepiness. Intensive Care Med 40(8):1124–1131PubMedPubMedCentralCrossRef Verceles AC, Corwin DS, Afshar M et al (2014) Half of the family members of critically ill patients experience excessive daytime sleepiness. Intensive Care Med 40(8):1124–1131PubMedPubMedCentralCrossRef
129.
go back to reference Bouju P, Tadie JM, Uhel F et al (2014) Internet use by family members of intensive care unit patients: a pilot study. Intensive Care Med 40(8):1175–1176PubMedCrossRef Bouju P, Tadie JM, Uhel F et al (2014) Internet use by family members of intensive care unit patients: a pilot study. Intensive Care Med 40(8):1175–1176PubMedCrossRef
130.
go back to reference Curtis JR, Sprung CL, Azoulay E (2014) The importance of word choice in the care of critically ill patients and their families. Intensive Care Med 40(4):606–608PubMedCrossRef Curtis JR, Sprung CL, Azoulay E (2014) The importance of word choice in the care of critically ill patients and their families. Intensive Care Med 40(4):606–608PubMedCrossRef
131.
go back to reference Debaty G, Ageron FX, Minguet L et al (2015) More than half the families of mobile intensive care unit patients experience inadequate communication with physicians. Intensive Care Med 41(7):1291–1298PubMedCrossRef Debaty G, Ageron FX, Minguet L et al (2015) More than half the families of mobile intensive care unit patients experience inadequate communication with physicians. Intensive Care Med 41(7):1291–1298PubMedCrossRef
132.
go back to reference Pochard F, Darmon M, Fassier T et al (2005) Symptoms of anxiety and depression in family members of intensive care unit patients before discharge or death. A prospective multicenter study. J Crit Care 20(1):90–96PubMedCrossRef Pochard F, Darmon M, Fassier T et al (2005) Symptoms of anxiety and depression in family members of intensive care unit patients before discharge or death. A prospective multicenter study. J Crit Care 20(1):90–96PubMedCrossRef
133.
go back to reference Long AC, Kross EK, Davydow DS, Curtis JR (2014) Posttraumatic stress disorder among survivors of critical illness: creation of a conceptual model addressing identification, prevention, and management. Intensive Care Med 40(6):820–829PubMedPubMedCentralCrossRef Long AC, Kross EK, Davydow DS, Curtis JR (2014) Posttraumatic stress disorder among survivors of critical illness: creation of a conceptual model addressing identification, prevention, and management. Intensive Care Med 40(6):820–829PubMedPubMedCentralCrossRef
134.
go back to reference Cox CE, Docherty SL, Brandon DH et al (2009) Surviving critical illness: acute respiratory distress syndrome as experienced by patients and their caregivers. Crit Care Med 37(10):2702–2708PubMedPubMedCentralCrossRef Cox CE, Docherty SL, Brandon DH et al (2009) Surviving critical illness: acute respiratory distress syndrome as experienced by patients and their caregivers. Crit Care Med 37(10):2702–2708PubMedPubMedCentralCrossRef
135.
go back to reference Evans RL, Bishop DS, Haselkorn JK (1991) Factors predicting satisfactory home care after stroke. Arch Phys Med Rehabil 72(2):144–147PubMed Evans RL, Bishop DS, Haselkorn JK (1991) Factors predicting satisfactory home care after stroke. Arch Phys Med Rehabil 72(2):144–147PubMed
136.
go back to reference Kao HF, McHugh ML (2004) The role of caregiver gender and caregiver burden in nursing home placements for elderly Taiwanese survivors of stroke. Res Nurs Health 27(2):121–134PubMedCrossRef Kao HF, McHugh ML (2004) The role of caregiver gender and caregiver burden in nursing home placements for elderly Taiwanese survivors of stroke. Res Nurs Health 27(2):121–134PubMedCrossRef
137.
go back to reference Chelluri L, Im KA, Belle SH et al (2004) Long-term mortality and quality of life after prolonged mechanical ventilation. Crit Care Med 32(1):61–69PubMedCrossRef Chelluri L, Im KA, Belle SH et al (2004) Long-term mortality and quality of life after prolonged mechanical ventilation. Crit Care Med 32(1):61–69PubMedCrossRef
138.
go back to reference Cameron JI, Herridge MS, Tansey CM, McAndrews MP, Cheung AM (2006) Well-being in informal caregivers of survivors of acute respiratory distress syndrome. Crit Care Med 34(1):81–86PubMedCrossRef Cameron JI, Herridge MS, Tansey CM, McAndrews MP, Cheung AM (2006) Well-being in informal caregivers of survivors of acute respiratory distress syndrome. Crit Care Med 34(1):81–86PubMedCrossRef
139.
go back to reference Johnson P, Chaboyer W, Foster M, van der Vooren R (2001) Caregivers of ICU patients discharged home: what burden do they face? Intensive Crit Care Nurs 17(4):219–227PubMedCrossRef Johnson P, Chaboyer W, Foster M, van der Vooren R (2001) Caregivers of ICU patients discharged home: what burden do they face? Intensive Crit Care Nurs 17(4):219–227PubMedCrossRef
140.
go back to reference Van Pelt DC, Milbrandt EB, Qin L et al (2007) Informal caregiver burden among survivors of prolonged mechanical ventilation. Am J Respir Crit Care Med 175(2):167–173PubMedPubMedCentralCrossRef Van Pelt DC, Milbrandt EB, Qin L et al (2007) Informal caregiver burden among survivors of prolonged mechanical ventilation. Am J Respir Crit Care Med 175(2):167–173PubMedPubMedCentralCrossRef
141.
go back to reference Rier DA (2014) From three sides now: reflections on an ICU journey as patient, parent, and researcher. Intensive Care Med 40(8):1162–1163PubMedCrossRef Rier DA (2014) From three sides now: reflections on an ICU journey as patient, parent, and researcher. Intensive Care Med 40(8):1162–1163PubMedCrossRef
142.
go back to reference Hopkins RO, Weaver LK, Pope D, Orme JF, Bigler ED, Larson LV (1999) Neuropsychological sequelae and impaired health status in survivors of severe acute respiratory distress syndrome. Am J Respir Crit Care Med 160(1):50–56PubMedCrossRef Hopkins RO, Weaver LK, Pope D, Orme JF, Bigler ED, Larson LV (1999) Neuropsychological sequelae and impaired health status in survivors of severe acute respiratory distress syndrome. Am J Respir Crit Care Med 160(1):50–56PubMedCrossRef
143.
go back to reference Mikkelsen ME, Shull WH, Biester RC, et al (2009) Cognitive, mood and quality of life impairments in a select population of ARDS survivors. Respirology 14(1):76–82CrossRef Mikkelsen ME, Shull WH, Biester RC, et al (2009) Cognitive, mood and quality of life impairments in a select population of ARDS survivors. Respirology 14(1):76–82CrossRef
144.
go back to reference Jackson JC, Hopkins RO, Miller RR, Gordon SM, Wheeler AP, Ely EW (2009) Acute respiratory distress syndrome, sepsis, and cognitive decline: a review and case study. South Med J 102(11):1150–1157PubMedPubMedCentralCrossRef Jackson JC, Hopkins RO, Miller RR, Gordon SM, Wheeler AP, Ely EW (2009) Acute respiratory distress syndrome, sepsis, and cognitive decline: a review and case study. South Med J 102(11):1150–1157PubMedPubMedCentralCrossRef
Metadata
Title
Recovery and outcomes after the acute respiratory distress syndrome (ARDS) in patients and their family caregivers
Authors
Margaret S. Herridge
Marc Moss
Catherine L. Hough
Ramona O. Hopkins
Todd W. Rice
O. Joseph Bienvenu
Elie Azoulay
Publication date
01-05-2016
Publisher
Springer Berlin Heidelberg
Published in
Intensive Care Medicine / Issue 5/2016
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-016-4321-8

Other articles of this Issue 5/2016

Intensive Care Medicine 5/2016 Go to the issue