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Open Access 01-12-2019 | Short communication

Voxel-based correlation of ¹⁸F-THK5351 accumulation and gray matter volume in the brain of cognitively normal older adults

Authors: Yoko Shigemoto, Daichi Sone, Miho Ota, Norihide Maikusa, Masayo Ogawa, Kyoji Okita, Harumasa Takano, Koichi Kato, Yukio Kimura, Emiko Morimoto, Fumio Suzuki, Hiroyuki Fujii, Noriko Sato, Hiroshi Matsuda

Published in: EJNMMI Research | Issue 1/2019

Abstract

Backgrounds

Although neurofibrillary tangles (NFTs) mainly accumulate in the medial temporal lobe with human aging, only a few imaging studies have investigated correlations between NFT accumulation and gray matter (GM) volume in cognitively normal older adults. Here, we investigated the correlations between ¹⁸F-THK5351 accumulation and GM volume at the voxel level.

Material and methods

We recruited 47 amyloid-negative, cognitively normal, older adults (65.0 ± 7.9 years, 26 women), who underwent structural magnetic resonance imaging, ¹¹C-Pittsburgh compound-B and ¹⁸F-THK5351 PET scans, and neuropsychological assessment. The magnetic resonance and ¹⁸F-THK5351 PET images were spatially normalized using Statistical Parametric Mapping 12. Voxel-wise correlations between ¹⁸F-THK5351 accumulation and GM volume were evaluated using the Biological Parametric Mapping toolbox.

Results

A significant negative correlation (p < 0.001) between ¹⁸F-THK5351 accumulation and GM volume was detected in the bilateral medial temporal lobes.

Conclusions

Voxel-wise correlation analysis revealed a significant negative correlation between ¹⁸F-THK5351 accumulation and GM volume in the medial temporal lobe in individuals without amyloid-β deposits. These results may contribute to a better understanding of the pathophysiology of primary age-related tauopathy in human aging.

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Title: Voxel-based correlation of 18F-THK5351 accumulation and gray matter volume in the brain of cognitively normal older adults
Authors: Yoko Shigemoto
Daichi Sone
Miho Ota
Norihide Maikusa
Masayo Ogawa
Kyoji Okita
Harumasa Takano
Koichi Kato
Yukio Kimura
Emiko Morimoto
Fumio Suzuki
Hiroyuki Fujii
Noriko Sato
Hiroshi Matsuda
Publication date: 01-12-2019
Publisher: Springer Berlin Heidelberg
Published in: EJNMMI Research / Issue 1/2019
Electronic ISSN: 2191-219X
DOI: https://doi.org/10.1186/s13550-019-0552-3

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Voxel-based correlation of ¹⁸F-THK5351 accumulation and gray matter volume in the brain of cognitively normal older adults

Abstract

Backgrounds

Material and methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Backgrounds

Material and methods

Results

Conclusions

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