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Open Access 01-12-2018 | Original research

A new SPECT/CT reconstruction algorithm: reliability and accuracy in clinical routine for non-oncologic bone diseases

Authors: Olivier Delcroix, Philippe Robin, Maelenn Gouillou, Alexandra Le Duc-Pennec, Zarrin Alavi, Pierre-Yves Le Roux, Ronan Abgral, Pierre-Yves Salaun, David Bourhis, Solène Querellou

Published in: EJNMMI Research | Issue 1/2018

Abstract

Background

xSPECT Bone® (xB) is a new reconstruction algorithm developed by Siemens® in bone hybrid imaging (SPECT/CT). A CT-based tissue segmentation is incorporated into SPECT reconstruction to provide SPECT images with bone anatomy appearance. The objectives of this study were to assess xB/CT reconstruction diagnostic reliability and accuracy in comparison with Flash 3D® (F3D)/CT in clinical routine. Two hundred thirteen consecutive patients referred to the Brest Nuclear Medicine Department for non-oncological bone diseases were evaluated retrospectively. Two hundred seven SPECT/CT were included. All SPECT/CT were independently interpreted by two nuclear medicine physicians (a junior and a senior expert) with xB/CT then with F3D/CT three months later. Inter-observer agreement (IOA) and diagnostic confidence were determined using McNemar test, and unweighted Kappa coefficient. The study objectives were then re-assessed for validation through > 18 months of clinical and paraclinical follow-up.

Results

No statistically significant differences between IOA _xB and IOA F3D were found (p = 0.532). Agreement for xB after categorical classification of the diagnoses was high (κ _xB = 0.89 [95% CI 0.84 –0.93]) but without statistically significant difference F3D (κ _F3D = 0.90 [95% CI 0.86 – 0.94]). Thirty-one (14.9%) inter-reconstruction diagnostic discrepancies were observed of which 21 (10.1%) were classified as major. The follow-up confirmed the diagnosis of F3D in 10 cases, xB in 6 cases and was non-contributory in 5 cases.

Conclusions

xB reconstruction algorithm was found reliable, providing high interobserver agreement and similar diagnostic confidence to F3D reconstruction in clinical routine.

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Title: A new SPECT/CT reconstruction algorithm: reliability and accuracy in clinical routine for non-oncologic bone diseases
Authors: Olivier Delcroix
Philippe Robin
Maelenn Gouillou
Alexandra Le Duc-Pennec
Zarrin Alavi
Pierre-Yves Le Roux
Ronan Abgral
Pierre-Yves Salaun
David Bourhis
Solène Querellou
Publication date: 01-12-2018
Publisher: Springer Berlin Heidelberg
Published in: EJNMMI Research / Issue 1/2018
Electronic ISSN: 2191-219X
DOI: https://doi.org/10.1186/s13550-018-0367-7

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

A new SPECT/CT reconstruction algorithm: reliability and accuracy in clinical routine for non-oncologic bone diseases

Abstract

Background

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background

Results

Conclusions

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