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Open Access 01-10-2014 | Research

Striatal and extrastriatal dopamine transporter levels relate to cognition in Lewy body diseases: an ¹¹C altropane positron emission tomography study

Authors: Marta Marquie, Joseph J Locascio, Dorene M Rentz, J Alex Becker, Trey Hedden, Keith A Johnson, John H Growdon, Stephen N Gomperts

Published in: Alzheimer's Research & Therapy | Issue 5-8/2014

Abstract

Introduction

The biological basis of cognitive impairment in parkinsonian diseases is believed to be multifactorial. We investigated the contribution of dopamine deficiency to cognition in Parkinson disease (PD) and dementia with Lewy bodies (DLB) with dopamine transporter (DAT) imaging.

Methods

We acquired ¹¹C altropane PET, magnetic resonance imaging and cognitive testing in 19 nondemented subjects with PD, 10 DLB and 17 healthy control subjects (HCS). We analyzed DAT concentration in putamen, caudate, anterior cingulate (AC), orbitofrontal and prefrontal regions, using the Standardized Uptake Volume Ratio with partial volume correction, and we related DAT concentration and global cortical thickness to neuropsychological performance.

Results

DAT concentration in putamen and in caudate were similar in PD and DLB groups and significantly lower than in HCS. Reduced caudate DAT concentration was associated with worse Clinical Dementia Rating Scale-sum of boxes (CDR-SB) scores and visuospatial skills in DLB but not in PD or HCS groups. Adjusting for putamen DAT concentration, as a measure of severity of motor disease, caudate DAT concentration was lower in DLB than in PD. Higher AC DAT concentration was associated with lower putamen DAT concentration in DLB and with higher putamen DAT concentration in PD. Higher AC DAT concentration in DLB correlated with greater impairment in semantic memory and language.

Conclusions

Caudate and AC dopamine dysfunction contribute in opposing directions to cognitive impairment in DLB.

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Title: Striatal and extrastriatal dopamine transporter levels relate to cognition in Lewy body diseases: an 11C altropane positron emission tomography study
Authors: Marta Marquie
Joseph J Locascio
Dorene M Rentz
J Alex Becker
Trey Hedden
Keith A Johnson
John H Growdon
Stephen N Gomperts
Publication date: 01-10-2014
Publisher: BioMed Central
Published in: Alzheimer's Research & Therapy / Issue 5-8/2014
Electronic ISSN: 1758-9193
DOI: https://doi.org/10.1186/s13195-014-0052-7

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Striatal and extrastriatal dopamine transporter levels relate to cognition in Lewy body diseases: an ¹¹C altropane positron emission tomography study

Abstract

Introduction

Methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusions

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