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Diabetology & Metabolic Syndrome
Published in: Diabetology & Metabolic Syndrome 1/2018

Open Access 01-12-2018 | Research

Plasma levels of lipopolysaccharide correlate with insulin resistance in HIV patients

Authors: Marcelo Nardi Pedro, Daniela Oliveira Magro, Elizabete Urbano Pinaço Pinto da Silva, Dioze Guadagnini, Andrey Santos, Rogerio de Jesus Pedro, Mario José Abdalla Saad

Published in: Diabetology & Metabolic Syndrome | Issue 1/2018

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Abstract

Background

In HIV patients using HAART insulin resistance is a central pathophysiological condition that can contribute to the development of diabetes and cardiovascular complications. To examine the role of adipocyte hormones and LPS in insulin resistance in HIV patients, we investigated the role of adiponectin, leptin, visfatin and LPS levels in the insulin resistance of HIV-infected patients treated with HAART.

Methods

This study included 67 HIV positive individuals on HAART and ten healthy controls. All participants performed plasma or serum levels of glucose; insulin; lipids, visfatin, leptin, adiponectin, and LPS. The homeostasis model assessment (HOMA-IR), was used to estimate insulin resistance.

Results

The levels of visfatin, leptin and adiponectin were similar between controls and HIV patients. However, circulating levels of LPS were higher in HIV patients on HAART than in controls. There was a positive correlation between LPS and TG (r = 0.49, p = 0.0001), between LPS and TG/HDL (r = 0.50, p = 0.0001), between LPS and insulin (r = 0.52, p = 0.0003), and between LPS and HOMA-IR (r = 0.52, p = 0.0005), in HIV patients.

Conclusions

Our results showed a clear correlation between plasma LPS and markers of insulin resistance, suggesting a relationship between LPS levels and metabolic alterations, particularly affecting lipids and insulin resistance in HIV patients.
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Metadata
Title
Plasma levels of lipopolysaccharide correlate with insulin resistance in HIV patients
Authors
Marcelo Nardi Pedro
Daniela Oliveira Magro
Elizabete Urbano Pinaço Pinto da Silva
Dioze Guadagnini
Andrey Santos
Rogerio de Jesus Pedro
Mario José Abdalla Saad
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Diabetology & Metabolic Syndrome / Issue 1/2018
Electronic ISSN: 1758-5996
DOI
https://doi.org/10.1186/s13098-018-0308-7

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