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Diabetology & Metabolic Syndrome
Published in: Diabetology & Metabolic Syndrome 1/2017

Open Access 01-12-2017 | Research

Shift work is associated with metabolic syndrome in male steel workers-the role of resistin and WBC count-related metabolic derangements

Authors: Yung-Chuan Lu, Chao-Ping Wang, Teng-Hung Yu, I-Ting Tsai, Wei-Chin Hung, I-Cheng Lu, Chia-Chang Hsu, Wei-Hua Tang, Jer-Yiing Houng, Fu-Mei Chung, Mei-Chu Yen Jean

Published in: Diabetology & Metabolic Syndrome | Issue 1/2017

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Abstract

Aims

There is increasing evidence linking a shift work schedule with various adverse health effects. The present study aimed to examine the relationship between shift work and the metabolic syndrome (MetS) in male steel workers, and also the possible mechanism of shift work-related metabolic derangements.

Methods

A total of 1732 men aged 42 ± 8 years were enrolled in this cross-sectional study, including 862 day workers and 870 shift workers. Circulating levels of resistin were measured by ELISA using monoclonal specific antibodies.

Results

The shift workers had higher rates of MetS and its components (central obesity, hypertension, and hypertriglyceridemia) than the day workers. In multiple logistic regression analysis, shift work was independently associated with MetS. In further analysis, the shift workers had elevated circulating levels of resistin (13 ± 10 vs. 10 ± 7 ng/mL) and total white blood cell (WBC) count (6.865 ± 1.819 vs. 6.304 ± 1.547 109/L) than the day workers. In addition, both resistin level and total WBC count were significantly associated with shift work, MetS, and its components (body mass index, fasting glucose, triglyceride, and high-density lipoprotein-cholesterol levels), and plasma resistin levels were significantly associated with total WBC count (β = 0.34, p < 0.0001).

Conclusion

Shift work was independently associated with MetS in male steel workers. Resistin and WBC count were associated with shift work-related metabolic derangements.
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Metadata
Title
Shift work is associated with metabolic syndrome in male steel workers-the role of resistin and WBC count-related metabolic derangements
Authors
Yung-Chuan Lu
Chao-Ping Wang
Teng-Hung Yu
I-Ting Tsai
Wei-Chin Hung
I-Cheng Lu
Chia-Chang Hsu
Wei-Hua Tang
Jer-Yiing Houng
Fu-Mei Chung
Mei-Chu Yen Jean
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Diabetology & Metabolic Syndrome / Issue 1/2017
Electronic ISSN: 1758-5996
DOI
https://doi.org/10.1186/s13098-017-0283-4

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