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Published in: Arthritis Research & Therapy 1/2017

Open Access 01-12-2017 | Editorial

Incident gout and erectile dysfunction: is hyperuricaemia the elephant in the room?

Authors: Abhishek Abhishek, Michael Doherty

Published in: Arthritis Research & Therapy | Issue 1/2017

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Abstract

The first prospective population-based study to examine risk of erectile dysfunction in men with gout in the western world has been published. It reports that following their first diagnosis of gout, men have a 31% higher risk of erectile dysfunction than matched controls, although the absolute increase in risk is small. Of interest, the incidence of erectile dysfunction reported in this study is tenfold higher than those reported in nation-wide cohort studies from Taiwan. There is a need for further prospective cohort studies to examine the possible mechanistic association between gout, hyperuricaemia and erectile dysfunction.
Literature
1.
go back to reference Abdul Sultan A, Mallen C, Hayward R, Muller S, Whittle R, Hotston M, Roddy E. Gout and subsequent erectile dysfunction: a population-based cohort study from England. Arthritis Res Ther. 2017;19(1):123.CrossRefPubMedPubMedCentral Abdul Sultan A, Mallen C, Hayward R, Muller S, Whittle R, Hotston M, Roddy E. Gout and subsequent erectile dysfunction: a population-based cohort study from England. Arthritis Res Ther. 2017;19(1):123.CrossRefPubMedPubMedCentral
2.
go back to reference Schlesinger N, Radvanski DC, Cheng JQ, Kostis JB. Erectile dysfunction is common among patients with gout. J Rheumatol. 2015;42(10):1893–7.CrossRefPubMed Schlesinger N, Radvanski DC, Cheng JQ, Kostis JB. Erectile dysfunction is common among patients with gout. J Rheumatol. 2015;42(10):1893–7.CrossRefPubMed
3.
go back to reference Chen YF, Lin HH, Lu CC, Hung CT, Lee MH, Hsu CY, Chung WS. Gout and a subsequent increased risk of erectile dysfunction in men aged 64 and under: a nationwide cohort study in Taiwan. J Rheumatol. 2015;42(10):1898–905.CrossRefPubMed Chen YF, Lin HH, Lu CC, Hung CT, Lee MH, Hsu CY, Chung WS. Gout and a subsequent increased risk of erectile dysfunction in men aged 64 and under: a nationwide cohort study in Taiwan. J Rheumatol. 2015;42(10):1898–905.CrossRefPubMed
4.
go back to reference Hsu CY, Lin CL, Kao CH. Gout is associated with organic and psychogenic erectile dysfunction. Eur J Intern Med. 2015;26(9):691–5.CrossRefPubMed Hsu CY, Lin CL, Kao CH. Gout is associated with organic and psychogenic erectile dysfunction. Eur J Intern Med. 2015;26(9):691–5.CrossRefPubMed
5.
go back to reference Campion EW, Glynn RJ, DeLabry LO. Asymptomatic hyperuricemia. Risks and consequences in the Normative Aging Study. Am J Med. 1987;82(3):421–6.CrossRefPubMed Campion EW, Glynn RJ, DeLabry LO. Asymptomatic hyperuricemia. Risks and consequences in the Normative Aging Study. Am J Med. 1987;82(3):421–6.CrossRefPubMed
6.
go back to reference Liddle J, Roddy E, Mallen CD, Hider SL, Prinjha S, Ziebland S, Richardson JC. Mapping patients’ experiences from initial symptoms to gout diagnosis: a qualitative exploration. BMJ Open. 2015;5(9):e008323.CrossRefPubMedPubMedCentral Liddle J, Roddy E, Mallen CD, Hider SL, Prinjha S, Ziebland S, Richardson JC. Mapping patients’ experiences from initial symptoms to gout diagnosis: a qualitative exploration. BMJ Open. 2015;5(9):e008323.CrossRefPubMedPubMedCentral
7.
go back to reference Kuo CF, Grainge MJ, Mallen C, Zhang W, Doherty M. Comorbidities in patients with gout prior to and following diagnosis: case-control study. Ann Rheum Dis. 2016;75(1):210–7.CrossRefPubMed Kuo CF, Grainge MJ, Mallen C, Zhang W, Doherty M. Comorbidities in patients with gout prior to and following diagnosis: case-control study. Ann Rheum Dis. 2016;75(1):210–7.CrossRefPubMed
8.
go back to reference Kuo CF, Grainge MJ, Mallen C, Zhang W, Doherty M. Rising burden of gout in the UK but continuing suboptimal management: a nationwide population study. Ann Rheum Dis. 2015;74(4):661–7.CrossRefPubMed Kuo CF, Grainge MJ, Mallen C, Zhang W, Doherty M. Rising burden of gout in the UK but continuing suboptimal management: a nationwide population study. Ann Rheum Dis. 2015;74(4):661–7.CrossRefPubMed
9.
go back to reference Kuo CF, Grainge MJ, Mallen C, Zhang W, Doherty M. Effect of allopurinol on all-cause mortality in adults with incident gout: propensity score-matched landmark analysis. Rheumatology (Oxford, England). 2015;54(12):2145–50. Kuo CF, Grainge MJ, Mallen C, Zhang W, Doherty M. Effect of allopurinol on all-cause mortality in adults with incident gout: propensity score-matched landmark analysis. Rheumatology (Oxford, England). 2015;54(12):2145–50.
Metadata
Title
Incident gout and erectile dysfunction: is hyperuricaemia the elephant in the room?
Authors
Abhishek Abhishek
Michael Doherty
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 1/2017
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/s13075-017-1394-x

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