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Critical Care
Published in: Critical Care 1/2020

01-12-2020 | Nutrition | Review

Biomarkers in critical care nutrition

Authors: Christian Stoppe, Sebastian Wendt, Nilesh M. Mehta, Charlene Compher, Jean-Charles Preiser, Daren K. Heyland, Arnold S. Kristof

Published in: Critical Care | Issue 1/2020

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Abstract

The goal of nutrition support is to provide the substrates required to match the bioenergetic needs of the patient and promote the net synthesis of macromolecules required for the preservation of lean mass, organ function, and immunity. Contemporary observational studies have exposed the pervasive undernutrition of critically ill patients and its association with adverse clinical outcomes. The intuitive hypothesis is that optimization of nutrition delivery should improve ICU clinical outcomes. It is therefore surprising that multiple large randomized controlled trials have failed to demonstrate the clinical benefit of restoring or maximizing nutrient intake. This may be in part due to the absence of biological markers that identify patients who are most likely to benefit from nutrition interventions and that monitor the effects of nutrition support. Here, we discuss the need for practical risk stratification tools in critical care nutrition, a proposed rationale for targeted biomarker development, and potential approaches that can be adopted for biomarker identification and validation in the field.
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Metadata
Title
Biomarkers in critical care nutrition
Authors
Christian Stoppe
Sebastian Wendt
Nilesh M. Mehta
Charlene Compher
Jean-Charles Preiser
Daren K. Heyland
Arnold S. Kristof
Publication date
01-12-2020
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2020
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-020-03208-7

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