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Critical Care
Published in: Critical Care 1/2020

Open Access 01-12-2020 | COVID-19 | Research Letter

VEGF-D: a novel biomarker for detection of COVID-19 progression

Authors: Yaxian Kong, Junyan Han, Xueying Wu, Hui Zeng, Jingyuan Liu, Henghui Zhang

Published in: Critical Care | Issue 1/2020

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Excerpt

As the coronavirus 2019 (COVID-19) continues to spread globally, hundreds of thousands have been infected, among whom approximately 15% of COVID-19 patients develop severe disease, and 5 to 6% are critically ill [1]. Critical patients of COVID-19 have a dramatically higher case fatality rate than severe cases. Thus, it is increasingly urgent to develop early and effective predictors to distinguish critical patients from severe patients. Storms of inflammatory cytokines and blood clots were reported to associate with severe disease and fatality of COVID-19 patients [2, 3]. We aimed to identify a biomarker for the detection of COVID-19 progression from numerous cytokines and coagulation indicators. …
Literature
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Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, Wang B, Xiang H, Cheng Z, Xiong Y et al: Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020;323(11):1061–9.
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Moore JB, June CH. Cytokine release syndrome in severe COVID-19. Science. 2020;368(6490):473–4.CrossRef
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Willyard C. Coronavirus blood-clot mystery intensifies. Nature. 2020;581(7808):250.CrossRef
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Wynants L, Van Calster B, Bonten MMJ, Collins GS, Debray TPA, De Vos M, Haller MC, Heinze G, Moons KGM, Riley RD, et al. Prediction models for diagnosis and prognosis of covid-19 infection: systematic review and critical appraisal. BMJ. 2020;369:m1328.CrossRef
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Zhang L, Yan X, Fan Q, Liu H, Liu X, Liu Z, Zhang Z: D-dimer levels on admission to predict in-hospital mortality in patients with Covid-19. J Thromb Haemost. 2020;18(6):1324–9.
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Verheul HM, Hoekman K, Lupu F, Broxterman HJ, van der Valk P, Kakkar AK, Pinedo HM. Platelet and coagulation activation with vascular endothelial growth factor generation in soft tissue sarcomas. Clin Cancer Res. 2000;6(1):166–71.PubMed
Metadata
Title
VEGF-D: a novel biomarker for detection of COVID-19 progression
Authors
Yaxian Kong
Junyan Han
Xueying Wu
Hui Zeng
Jingyuan Liu
Henghui Zhang
Publication date
01-12-2020
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2020
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-020-03079-y

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