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Open Access 01-12-2019 | Metabolic Alkalosis | Letter

Trial sequential analysis suggested the potential overestimated effect of carbonic anhydrase inhibitor for respiratory failure and metabolic alkalosis

Authors: Meng-Si Luo, Hui-Zi Li, Guan-Jiang Huang, Lun Wu

Published in: Critical Care | Issue 1/2019

Excerpt

Meta-analyses of randomized controlled trials (RCTs) used to be considered as the optimum evidence to guide clinical practices. Generally, a high-quality meta-analysis with conclusive information should meet the minimum requirements of a well-conducted RCT, which includes prospective protocol development, limitation of bias, and adequate sample size [1]. Conversely, meta-analyses based on limited RCTs may trigger the potential overestimation of the authentic intervention effect owing to weak statistical power [1]. More interestingly, increasing studies indicated that pooled results with false positive were frequently existed in published meta-analyses including many Cochrane ones [2, 3]. …

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Imberger G, Thorlund K, Gluud C, et al. False-positive findings in Cochrane meta-analyses with and without application of trial sequential analysis: an empirical review. BMJ Open. 2016;6:e011890.CrossRef

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Tanios BY, Omran MO, Noujeim C, et al. Carbonic anhydrase inhibitors in patients with respiratory failure and metabolic alkalosis: a systematic review and meta-analysis of randomized controlled trials. Crit Care. 2018;22:275.CrossRef

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Guyatt GH, Oxman AD, Kunz R, Brozek J, Alonso-Coello P, Rind D, et al. GRADE guidelines 6. Rating the quality of evidence--imprecision. J Clin Epidemiol. 2011;64(12):1283–93.

Title: Trial sequential analysis suggested the potential overestimated effect of carbonic anhydrase inhibitor for respiratory failure and metabolic alkalosis
Authors: Meng-Si Luo
Hui-Zi Li
Guan-Jiang Huang
Lun Wu
Publication date: 01-12-2019
Publisher: BioMed Central
Keywords: Metabolic Alkalosis
Carbonic Anhydrase Inhibitor
Published in: Critical Care / Issue 1/2019
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/s13054-019-2384-y

Keynote webinar | Spotlight on sleep in brain health

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Trial sequential analysis suggested the potential overestimated effect of carbonic anhydrase inhibitor for respiratory failure and metabolic alkalosis

Excerpt

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

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