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Critical Care
Published in: Critical Care 1/2018

Open Access 01-12-2018 | Letter

Gram stain-guided antibiotic choice: a GRACEful method to safely restrict overuse of broad-spectrum antibiotic agents

Authors: Jumpei Yoshimura, Kazuma Yamakawa, Takahiro Kinoshita, Satoshi Fujimi

Published in: Critical Care | Issue 1/2018

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Excerpt

The rapid pandemic spread of multidrug-resistant (MDR) pathogens and the paucity of new, effective antibiotics are placing patients’ safety at risk worldwide [1]. The World Health Organization (WHO) adopted a global action plan on antimicrobial resistance, emphasising the need to optimise the use of antibiotic agents [2]. We recently reported in Critical Care the effectiveness of Gram stain results to reduce the use of broad-spectrum antibiotics [3]. Here, we would like to report the prospective validation of the usefulness of Gram staining for antibiotic choice. …
Appendix
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Literature
1.
Laxminarayan R, Duse A, Wattal C, Zaidi AK, Wertheim HF, Sumpradit N, et al. Antibiotic resistance—the need for global solutions. Lancet Infect Dis. 2013;12:1057–98.CrossRef
2.
3.
Yoshimura J, Kinoshita T, Yamakawa K, Matsushima A, Nakamoto N, Hamasaki T, et al. Impact of Gram stain results on initial treatment selection in patients with ventilator-associated pneumonia: a retrospective analysis of two treatment algorithms. Crit Care. 2017;21:156.CrossRef
4.
Kalil AC, Metersky ML, Klompas M, Muscedere J, Sweeney DA, Palmer LB, et al. Management of Adults With Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society. Clin Infect Dis. 2016;63:e61–e111.CrossRef
5.
Yoshimura J, Yamakawa K, Kinoshita T, Ohta Y, Morimoto T. GRam stain-guided Antibiotics ChoicE for Ventilator-Associated Pneumonia (GRACE-VAP) trial: rationale and study protocol for a randomised controlled trial. Trials. 2018;19:614.CrossRef
Metadata
Title
Gram stain-guided antibiotic choice: a GRACEful method to safely restrict overuse of broad-spectrum antibiotic agents
Authors
Jumpei Yoshimura
Kazuma Yamakawa
Takahiro Kinoshita
Satoshi Fujimi
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2018
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-018-2270-z

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