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Critical Care
Published in: Critical Care 1/2018

Open Access 01-12-2018 | Letter

A brief comment on the predictive value of myeloperoxidase-conjugated DNA level in patients with septic shock

Authors: Xu Li, Xiaochun Ma

Published in: Critical Care | Issue 1/2018

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Excerpt

We read with great interest the recent article by Maruchi et al., “Plasma myeloperoxidase-conjugated DNA level predicts outcomes and organ dysfunction in patients with septic shock” [1], in which the authors conducted a concise study of the predictive value of plasma myeloperoxidase (MPO)-conjugated DNA level in septic shock patients. MPO-DNA and cell-free DNA (cf-DNA) are components of neutrophil extracellular traps (NETs), which play an important role in the process of sepsis. However, the effects of NETs and the precise mechanism are still a matter of debate [2]. We would like to offer the following comments. …
Literature
1.
Maruchi Y, Tsuda M, Mori H, et al. Plasma myeloperoxidase-conjugated DNA level predicts outcomes and organ dysfunction in patients with septic shock. Crit Care. 2018;22(1):176.CrossRef
2.
de Bont CM, Boelens WC, Pruijn GJM. NETosis, complement, and coagulation: a triangular relationship. Cell Mol Immunol. 2018;23 Epub ahead of print.
3.
Ito T. PAMPs and DAMPs as triggers for DIC. J Intensive Care. 2014;2(1):67.CrossRef
4.
Delabranche X, Stiel L, Severac F, Galoisy AC, Mauvieux L, et al. Evidence of NETosis in septic shock-induced disseminated intravascular coagulation. Shock. 2017;47:313–7.CrossRef
5.
Stiel L, Meziani F, Helms J. Neutrophil activation during septic shock. Shock. 2018;49(4):371–84.CrossRef
Metadata
Title
A brief comment on the predictive value of myeloperoxidase-conjugated DNA level in patients with septic shock
Authors
Xu Li
Xiaochun Ma
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2018
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-018-2246-z

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