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Open Access 01-12-2018 | Letter

Is protein intake saturated at doses recommended by the feeding guidelines for critically ill patients?

Authors: Jan Gunst, Michael P. Casaer

Published in: Critical Care | Issue 1/2018

Excerpt

The ideal protein intake for critically ill patients is still debated [1]. Guidelines recommend minimum doses of 1.2–1.3 g protein/kg/day for non-obese critically ill patients and doses up to 2.0–2.5 g/kg ideal body weight (IBW)/day for obese critically ill patients [2]. Yet, achieved intakes often do not meet the recommended targets and several randomized controlled trials have shown absence of clinical benefit and increased ureagenesis by strategies that increased amino acid administration to critically ill patients [1]. A recent mechanistic study implicated amino acid-induced glucagon secretion as a potential mediator of amino acid catabolism, which may drive a futile cycle [3]. …

Gunst J, Vanhorebeek I, Thiessen SE, Van den Berghe G. Amino acid supplements in critically ill patients. Pharmacol Res. 2018;130:127–31.CrossRefPubMed

McClave SA, Taylor BE, Martindale RG, Warren MM, Johnson DR, Braunschweig C, McCarthy MS, Davanos E, Rice TW, Cresci GA, et al. Guidelines for the provision and assessment of nutrition support therapy in the adult critically ill patient: Society of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (ASPEN). J Parenter Enteral Nutr. 2016;40(2):159–211.CrossRef

Thiessen SE, Derde S, Derese I, Dufour T, Albert Vega C, Langouche L, Goossens C, Peersman N, Vermeersch P, Vander Perre S, et al. Role of glucagon in catabolism and muscle wasting of critical illness and modulation by nutrition. Am J Respir Crit Care Med. 2017;196(9):1131–43.CrossRefPubMed

van Zanten ARH, Petit L, De Waele J, Kieft H, de Wilde J, van Horssen P, Klebach M, Hofman Z. Very high intact-protein formula successfully provides protein intake according to nutritional recommendations in overweight critically ill patients: a double-blind randomized trial. Crit Care. 2018;22(1):156.CrossRefPubMedPubMedCentral

Gunst J, Vanhorebeek I, Casaer MP, Hermans G, Wouters PJ, Dubois J, Claes K, Schetz M, Van den Berghe G. Impact of early parenteral nutrition on metabolism and kidney injury. J Am Soc Nephrol. 2013;24(6):995–1005.CrossRefPubMedPubMedCentral

Title: Is protein intake saturated at doses recommended by the feeding guidelines for critically ill patients?
Authors: Jan Gunst
Michael P. Casaer
Publication date: 01-12-2018
Publisher: BioMed Central
Published in: Critical Care / Issue 1/2018
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/s13054-018-2149-z

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Is protein intake saturated at doses recommended by the feeding guidelines for critically ill patients?

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