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Critical Care
Published in: Critical Care 1/2017

Open Access 01-12-2017 | Editorial

Recovery from critical illness-induced organ failure: the role of autophagy

Author: Jan Gunst

Published in: Critical Care | Issue 1/2017

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Abstract

Autophagy is a catabolic process by which cells can dispose of damaged content and intracellular microorganisms. Recent evidence implicates autophagy as a crucial repair process necessary to recover from critical illness-induced organ failure. Withholding parenteral nutrition in the acute phase of critical illness activates autophagy and enhances recovery. Several registered drugs have autophagy-stimulating properties, but all lack specificity and none has been investigated in critically ill patients for this purpose.
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Metadata
Title
Recovery from critical illness-induced organ failure: the role of autophagy
Author
Jan Gunst
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2017
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-017-1786-y

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