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Critical Care
Published in: Critical Care 1/2017

Open Access 01-12-2017 | Letter

Response to “Reassessing the death risk related to probiotics in critically ill patients”

Authors: William Manzanares, Paul E. Wischmeyer

Published in: Critical Care | Issue 1/2017

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Excerpt

We would like to thank Dr. Maraolo for his valuable and careful analysis [1] of the data of our recently published systematic review and meta-analysis on probiotic and synbiotic therapy in the critically ill [2]. As Dr. Maraolo has observed we have made an error in the calculation of the pooled risk ratio (RR) and 95% confidence interval (CI) for the effect of probiotics on hospital mortality. When we abstracted mortality data from the Besselink et al. [3] study we included correct data in both arms (24 of 152 and 9 of 144 patients in the probiotic and placebo groups, respectively). Nonetheless, we made a mistake creating the forest plot. Please, accept our sincere apologies. …
Literature
1.
Maraolo AE. Reassessing the death risk related to probiotics in critically ill patients. Crit Care. 2016;20:338.CrossRef
2.
Manzanares W, Lemieux M, Langlois PL, Wischmeyer PE. Probiotic and synbiotic therapy in critical illness: a systematic review and meta-analysis. Crit Care. 2016;20:262.CrossRefPubMedCentral
3.
Besselink MG, van Santvoort HC, Buskens E, Boermeester MA, van Goor H, Timmerman HM, Nieuwenhuijs VB, Bollen TL, van Ramshorst B, Witteman BJ, Rosman C, Ploeg RJ, Brink MA, Schaapherder AF, Dejong CH, Wahab PJ, van Laarhoven CJ, Van der Harst E, van Eijck CH, Cuesta MA, Akkermans LM, Gooszen HG, Dutch Acute Pancreatitis Study Group. Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind,placebo-controlled trial. Lancet. 2008;371:651–9.CrossRefPubMed
4.
Urben LM, Wiedmar J, Boettcher E, Cavallazzi R, Martindale RG, McClave SA. Bugs or drugs: are probiotics safe for use in the critically ill? Curr Gastroenterol Rep. 2014;16:388.CrossRefPubMed
Metadata
Title
Response to “Reassessing the death risk related to probiotics in critically ill patients”
Authors
William Manzanares
Paul E. Wischmeyer
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2017
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-017-1618-0

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