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Critical Care
Published in: Critical Care 1/2016

Open Access 01-12-2016 | Letter

Reassessing the death risk related to probiotics in critically ill patients

Author: Alberto Enrico Maraolo

Published in: Critical Care | Issue 1/2016

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Excerpt

Manzanares and colleagues, in their very comprehensive systematic review with meta-analysis [1], conclude that probiotics prove to be a very useful weapon to reduce infections in critically ill patients, although strong recommendation in support of their use cannot be drawn yet. Indeed, they correctly state that publication bias and heterogeneity of the included studies could undermine their conclusions [1]. Another relevant aspect of the paper is the safety profile of probiotics, a well-known matter of debate: no effect was observed upon length-of-stay, diarrhea, and, most of all, mortality [1]. …
Literature
1.
Manzanares W, Lemieux M, Langlois PL, Wischmeyer PE. Probiotic and synbiotic therapy in critical illness: a systematic review and meta-analysis. Crit Care. 2016;20:262.CrossRefPubMedCentral
2.
Besselink MG, van Santvoort HC, Buskens E, Boermeester MA, van Goor H, Timmerman HM, Nieuwenhuijs VB, Bollen TL, van Ramshorst B, Witteman BJ, Rosman C, Ploeg RJ, Brink MA, Schaapherder AF, Dejong CH, Wahab PJ, van Laarhoven CJ, van der Harst E, van Eijck CH, Cuesta MA, Akkermans LM, Gooszen HG, Dutch Acute Pancreatitis Study Group. Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial. Lancet. 2008;371:651–9.CrossRefPubMed
3.
Gou S, Yang Z, Liu T, Wu H, Wang C. Use of probiotics in the treatment of severe acute pancreatitis: a systematic review and meta-analysis of randomized controlled trials. Crit Care. 2014;18:R57.CrossRefPubMedPubMedCentral
4.
Doron S, Snydman DR. Risk and safety of probiotics. Clin Infect Dis. 2015;60(S2):S120–34.
Metadata
Title
Reassessing the death risk related to probiotics in critically ill patients
Author
Alberto Enrico Maraolo
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2016
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-016-1565-1

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