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Italian Journal of Pediatrics
Published in: Italian Journal of Pediatrics 1/2019

Open Access 01-12-2019 | Research

Comparative two time-point proteome analysis of the plasma from preterm infants with and without bronchopulmonary dysplasia

Authors: Magdalena Zasada, Maciej Suski, Renata Bokiniec, Monika Szwarc-Duma, Maria Katarzyna Borszewska-Kornacka, Józef Madej, Beata Bujak-Giżycka, Anna Madetko-Talowska, Cecilie Revhaug, Lars O. Baumbusch, Ola D. Saugstad, Jacek Józef Pietrzyk, Przemko Kwinta

Published in: Italian Journal of Pediatrics | Issue 1/2019

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Abstract

Background

In this study, we aimed to analyze differences in plasma protein abundances between infants with and without bronchopulmonary dysplasia (BPD), to add new insights into a better understanding of the pathogenesis of this disease.

Methods

Cord and peripheral blood of neonates (≤ 30 weeks gestational age) was drawn at birth and at the 36th postmenstrual week (36 PMA), respectively. Blood samples were retrospectively subdivided into BPD(+) and BPD(−) groups, according to the development of BPD.

Results

Children with BPD were characterized by decreased afamin, gelsolin and carboxypeptidase N subunit 2 levels in cord blood, and decreased galectin-3 binding protein and hemoglobin subunit gamma-1 levels, as well as an increased serotransferrin abundance in plasma at the 36 PMA.

Conclusions

BPD development is associated with the plasma proteome changes in preterm infants, adding further evidence for the possible involvement of disturbances in vitamin E availability and impaired immunological processes in the progression of prematurity pulmonary complications. Moreover, it also points to the differences in proteins related to infection resistance and maintaining an adequate level of hematocrit in infants diagnosed with BPD.
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Metadata
Title
Comparative two time-point proteome analysis of the plasma from preterm infants with and without bronchopulmonary dysplasia
Authors
Magdalena Zasada
Maciej Suski
Renata Bokiniec
Monika Szwarc-Duma
Maria Katarzyna Borszewska-Kornacka
Józef Madej
Beata Bujak-Giżycka
Anna Madetko-Talowska
Cecilie Revhaug
Lars O. Baumbusch
Ola D. Saugstad
Jacek Józef Pietrzyk
Przemko Kwinta
Publication date
01-12-2019
Publisher
BioMed Central
Published in
Italian Journal of Pediatrics / Issue 1/2019
Electronic ISSN: 1824-7288
DOI
https://doi.org/10.1186/s13052-019-0676-0

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