Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on sleep in brain health

LIVE: Thursday 2nd May 2024, 18:00-19:30 (CEST)

Quality sleep is essential for health. But what happens to our brains when sleep patterns are disturbed? Join our experts to explore the interplay between sleep disruption and neurological diseases, and the questions that you need to be asking your patients to help you prevent the harmful effects of sleep deprivation.
ADVANCED SEARCH
Log in
Top
Italian Journal of Pediatrics
Published in: Italian Journal of Pediatrics 1/2018

Open Access 01-12-2018 | Review

SIAIP position paper: provocation challenge to antibiotics and non-steroidal anti-inflammatory drugs in children

Authors: Carlo Caffarelli, Fabrizio Franceschini, Davide Caimmi, Francesca Mori, Lucia Diaferio, Dora Di Mauro, Carla Mastrorilli, Stefania Arasi, Simona Barni, Paolo Bottau, Silvia Caimmi, Fabio Cardinale, Pasquale Comberiati, Giuseppe Crisafulli, Lucia Liotti, Umberto Pelosi, Francesca Saretta, Gianluigi Marseglia, Marzia Duse, Francesco Paravati

Published in: Italian Journal of Pediatrics | Issue 1/2018

Login to get access

Abstract

Drug hypersensitivity reactions (DHRs) in childhood are mainly caused by betalactam or non-betalactam antibiotics, and non-steroidal anti-inflammatory drugs (NSAIDs). Laboratory tests for identifying children who are allergic to drugs have low diagnostic accuracy and predictive value. The gold standard to diagnose DHR is represented by the drug provocation test (DPT), that aims of ascertaining the causative role of an allergen and evaluating the tolerance to the suspected drug. Different protocols through the administration of divided increasing doses have been postulated according to the type of drug and the onset of the reaction (immediate or non immediate reactions). DPT protocols differ in doses and time interval between doses. In this position paper, the Italian Pediatric Society for Allergy and Immunology provides a practical guide for provocation test to antibiotics and NSAIDs in children and adolescents.
Literature
1.
Macy E, Romano A, Khan DJ. Practical Management of Antibiotic Hypersensitivity in 2017. Allergy Clin Immunol Pract. 2017;5:577–86.CrossRef
2.
Gomes ER, Brockow K, Kuyucu S, Saretta F, Mori F, Blanca-Lopez N, Ott H, Atanaskovic-Markovic M, Kidon M, Caubet JC, Terreehorst I, ENDA/EAACI Drug Allergy Interest Group. Drug hypersensitivity in children: report from the pediatric task force of the EAACI Drug Allergy Interest Group. Allergy. 2016;71:149–61.CrossRefPubMed
3.
Clavenna A, Bonari M. Adverse drug reactions in childhood: a review of prospective studies and safety alerts. Arch Dis Child. 2009;94:724–8.CrossRefPubMed
4.
Rubio M, Bousquet PJ, Gomes E, Romano A, Demoly P. Results of drug hypersensitivity evaluations in a large group of children and adults. Clin Exp Allergy. 2011;42:123–30.CrossRefPubMed
5.
6.
Demoly P, Adkinson NF, Brockow K, Castells M, Chiriac AM, Greenberger PA, Khan DA, Lang DM, Park HS, Pichler W, Sanchez-Borges M, Shiohara T, Thong BY. International consensus on drug allergy. Allergy. 2014;69:420–37.CrossRefPubMed
7.
Pichler WJ, Hausmann O. Classification of drug hypersensitivity into Allergic, p-i and pseudo-allergic forms. Int Arch Allergy Immunol. 2016;171:166–79.CrossRefPubMed
8.
Pichler WJ. Delayed drug hypersensitivity reactions. Ann Intern Med. 2003;21(139):683–93.CrossRef
9.
Caffarelli C, Cuomo B, Cardinale F, Barberi S, Povesi Dascola C, Agostinis F, Franceschini F, Bernardini R. Aetiological factors associated with chronic urticaria in children: a systematic review. Acta Derm Venereol. 2013;93:268–72.CrossRefPubMed
10.
Galli E, Neri I, Ricci G, Baldo E, Barone M, Belloni Fortina A, Bernardini R, Berti I, Caffarelli C, Calamelli E, Capra L, Carello R, Cipriani F, Comberiati P, Diociaiuti A, El Hachem M, Fontana E, Gruber M, Haddock E, Maiello N, Meglio P, Patrizi A, Peroni D, Scarponi D, Wielander I, Eichenfield LF. Consensus conference on clinical management of pediatric atopic dermatitis. Ital J Pediatr. 2016;42:26.CrossRefPubMedPubMedCentral
11.
Romano A, Torres MJ, Castells M, Sanz ML, Blanca M. Diagnosis and management of drug hypersensitivity reactions. J Allergy Clin Immunol. 2011;127:S67–73.CrossRefPubMed
12.
Bircher AJ, Scherer Hofmeier K. Drug hypersensitivity reactions: inconsistency in the use of the classification of immediate and non immediate reactions. J Allergy Clin Immunol. 2012;129:263–4.CrossRefPubMed
13.
Mill C, Primeau MN, Medoff E, Lejtenyi C, O'Keefe A, Netchiporouk E, Dery A, Ben-Shoshan M. Assessing the diagnostic properties of a graded oral provocation challenge for the diagnosis of immediate and non immediate reactions to amoxicillin in children. JAMA Pediatr. 2016;170:e160033.CrossRefPubMed
14.
Ponvert C, Perrin Y, Bados-Albiero A, Le Bourgeois M, Karila C, Delacourt C, Sheinmann P, De Blic J. Allergy to beta-lactam antibiotics in children: results of a20-year study based on clinical history, skin and challenge tests. Pediatr Allergy Immunol. 2011;22:411–8.CrossRefPubMed
15.
Romano A, Gaeta F, Valluzzi RL, Maggioletti M, Zaffiro A, Caruso C, Quarantino D. IgE-mediated hypersensitivity to cephalosporins: cross-reactivity and tolerability of alternative cephalosporins. J Allergy Clin Immunol. 2015;136:685–691.e.CrossRefPubMed
16.
Blanca-López N, Cornejo-García JA, Plaza-Serón MC, Doña I, Torres-Jaén MJ, Canto G, Padilla-España L, Kidon M, Perkins JR, Blanca M. Hypersensitivity to nonsteroidal anti-inflammatory drugs in children and adolescents: cross-intolerance reactions. J Investig Allergol Clin Immunol. 2015;25:259–69.PubMed
17.
Martin-Muñoz F, Moreno-Ancillo A, Domínguez-Noche C, et al. Evaluation of drug-related hypersensitivity reactions in children. J Investig Allergol Clin Immunol. 1999;9:172–7.PubMed
18.
Chen CJ, Cheng CF, Lin HY, Hung SP, Chen WC, Lin MS. A comprehensive 4-year survey of adverse drug reactions using a network-based hospital system. J Clin Pharm Ther. 2012;37:647–51.CrossRefPubMed
19.
Khaled A, Kharfi M, Ben Hamida M, et al. Cutaneous adverse drug reactions in children. A series of 90 cases. Tunis Med. 2012;90:45–50.PubMed
20.
Rebelo Gomes E, Fonseca J, Araujo L, Demoly P. Drug allergy claims in children: from self-reporting to confirmed diagnosis. Clin Exp Allergy. 2008;38:191–8.PubMed
21.
Jares EJ, Baena-Cagnani CE, Sánchez-Borges M, et al. Drug-induced anaphylaxis in latin american countries. J Allergy Clin Immunol Pract. 2015;3:780–8.CrossRefPubMed
22.
Mars T, Fox AT, Lack G, du Toit G. The diagnosis and management of antibiotic allergy in children: systematic review to inform a contemporary approach. Arch Dis Child. 2015;100:583–8.CrossRef
23.
Makowska JS, Burney P, Jarvis D, Keil T, Tomassen P, Bislimovska J, Brozek G, Bachert C, Baelum J, Bindslev-Jensen C, Bousquet J, Bousquet PJ, Kai-Hakon C, Dahlen SE, Dahlen B, Fokkens WJ, Forsberg B, Gjomarkaj M, Howarth P, Janson C, Kasper L, Kraemer U, Louiro C, Lundback B, Minov J, Nizankowska-Mogilnicka E, Papadopoulos N, Sakellariou AG, Todo-Bom A, Toskala E, Zejda JE, Zuberbier T, Kowalski ML. Respiratory hypersensitivity reactions to NSAIDs in Europe: the global allergy and asthma network (GA2LEN) survey. Allergy. 2016;71:1603–11.CrossRefPubMed
24.
Blanca-Lopez N, Cornejo-Garcia JA, Perez-Alzate D, Perez-Sanchez N, Plaza-Seron MC, Dona I, Torres MJ, Canto G, Kidon M, Perkins JR, Blanca M. Hypersensitivity reactions to nonsteroidal anti-inflammatory drugs in children and adolescents: selective reactions. J Investig Allergol Clin Immunol. 2015;25:385–95.PubMed
25.
Aberer W, Bircher A, Romano A, Blanca M, Campi P, Fernandez J, Brokow K, Pichler WJ, Demoly P. Drug provocation testing in the diagnosis of drug hypersensitivity reactions: general considerations. Allergy. 2003;58:854–63.CrossRefPubMed
26.
Khan DA. Treating patients with multiple drug allergies. Ann Allergy Asthma Immunol. 2013;110:2–6.CrossRefPubMed
27.
Kidon M, Blanca-Lopez N, Gomes E, Terreehorst I, Tanno L, Ponvert C, Chin CW, Caubet JC, Soyer O, Mori F, Blanca M, Atanaskovic-Markovic M. EAACI/ENDA position paper: diagnosis and management of hypersensitivity reactions to non-steroidal anti-inflammatory drugs (NSAIDs) in children and adolescents. Pediatr Allergy Immunol. 2018;29:469–80.CrossRefPubMed
28.
Caffarelli C, Ricò S, Rinaldi L, Povesi Dascola C, Terzi C, Bernasconi S. Blood pressure monitoring in children undergoing food challenge: relationship with anaphylaxis. Ann Allergy Asthma Immunol. 2012;108:285–6.CrossRefPubMed
29.
Mirakian R, Leech SC, Krishna MT, Richter AG, Huber PA, Farooque S, Khan N, Pirmohamed M, Clark AT, Nasser SM. Standards of Care Committee of the British Society for Allergy and Clinical Immunology. Management of allergy to penicillins and other beta-lactams. Clin Exp Allergy. 2016;45:300–27.CrossRef
30.
Macy E, Ho NJ. Multiple drug intolerance syndrome: prevalence, clinical characteristics, and management. Ann Allergy Asthma Immunol. 2012;108:88–93.CrossRefPubMed
31.
Demoly P, Romano A, Botelho C, Bousquet-Rouanet L, Gaeta F, Silva R, Rumi G, rodrigues Cernadas J, Bosquet PJ. Determining the negative predictive value of provocation tests with betalactams. Allergy. 2010;65:327–32.CrossRefPubMed
32.
Perez-Inestrosa E, Suau R, Montanez MI, Rodriguez R, Mayorga C, Torres MJ, Blanca M. Cephalosporin chemical reactivity and its immunological implications. Curr Opin Allergy Immunol. 2005;5:323–30.CrossRef
33.
Blanca M, Vega JM, Garcia J, Miranda A, Carmona MJ, Juarez C, Terrados S, Fernandez J. New aspects of allergic reactions to betalactams: cross reactions and unique specificities. Clin Exp Allergy. 1994;24:407–15.CrossRefPubMed
34.
Romano A, Gueant-Rodriguez RM, Viola M, Pettinato R, Gueant JL. Cross-reactivity and tolerability of cephalosporins in patients with immediate hypersensitivity to penicillins. Ann Intern Med. 2004;141:16–22.CrossRefPubMed
35.
36.
Pichichero ME, Casey JR. Safe use of selected cephalosporins in penicillin-allergic patients: a meta-analysis. Otolaryngol Head Neck Surg. 2007;136:340–7.CrossRefPubMed
37.
Pipet A, Veyrac G, Wessel F, Jolliet P, Magnan A, Demoly P, Bousquet PJ. A statement on cefazolin immediate hypersensitivity: data from a large database, and focus on the cross-reactivities. Clin Exp Allergy. 2011;41:1602–8.CrossRefPubMed
38.
Atanasković-Marković M. Educational case series: β-lactam allergy and cross-reactivity. Pediatr Allergy Immunol. 2011;22:770–5.CrossRefPubMed
39.
Pichichero ME. A review of evidence supporting the American Academy of Pediatrics recommendation for prescribing cephalosporin antibiotics for penicillin allergic patients. Pediatrics. 2005;115:1048.CrossRefPubMed
40.
Kearns GL, Wheeler JG, Rieder MJ, Reid J. Serum sickness-like reaction to cefaclor: lack of in vitro cross-reactivity with loracarbef. Clin Pharmacol Ther. 1998;93:686–93.CrossRef
41.
Romano A, Gaeta F, Valluzzi RL, Maggioletti M, Caruso C, Quaratino D. Cross-reactivity and tolerability of aztreonam and cephalosporins in subjects with a T cell-mediated hypersensitivity to penicillins. J Allergy Clin Immunol. 2016;138:179–86.CrossRefPubMed
42.
Brockow K, Garvey LH, Aberer W, Atanaskovic-Markovic M, Barbaud A, Bilo MB, Bircher A, Blanca M, Bonadonna B, Campi P, Castro E, Cernadas JR, Chiriac AM, Demoly P, Grosber M, Gooi J, Lombardo C, Mertes PM, Mosbech H, Nasser S, Pagani M, Ring J, Romano A, Scherer K, Schnyder B, Testi S, Torres M, Trautmann A, Terreehorst I, ENDA/EAACI drug allergy interest group. Skin test concentrations for systemically administered drugs an ENDA/EAACI Drug Allergy Interest Group position paper. Allergy. 2013;68:702–12.CrossRefPubMed
43.
Torres MJ, Salas M, Ariza A, Fernández TD. Understanding the mechanisms in accelerated drug reactions. Curr Opin Allergy Clin Immunol. 2016;16:308–14.CrossRefPubMed
44.
Tortajada Girbés M, Ferrer Franco A, Gracia Antequera M, Clement Parede A, Garcia Muñoz E, Tallón Guerola M. Hypersensitivity to clavulanic acid in children. Allergol Immunopathol. 2008;36:308–10.CrossRef
45.
Macy E, Ngor EW. Safely diagnosing clinically significant penicillin allergy using only penicilloyl-poly-lysine, penicillin, and oral amoxicillin. J Allergy Clin Immunol Pract. 2013;1:258–63.CrossRefPubMed
46.
Hershkovich J, Broides A, Kirjner L, Smith H, Gorodischer R. Beta lactam allergy and resensitization in children with suspected beta lactam allergy. Clin Exp Allergy. 2009;39:726–30.CrossRefPubMed
47.
García Núñez I, Barasona Villarejo MJ, Algaba Mármol MA, Moreno Aguilar C, Guerra Pasadas F. Diagnosis of patients with immediate hypersensitivity to beta-lactams using retest. J Investig Allergol Clin Immunol. 2012;22:41–7.PubMed
48.
49.
Mill C, Primeau MN, Medoff E, Lejtenyi C, O'Keefe A, Netchiporouk E, Dery A, Ben-Shoshan M. Assessing the diagnostic properties of a graded oral provocation challenge for the diagnosis of immediate and nonimmediate reactions to amoxicillin in children. JAMA Pediatr. 2016;170(6):e160033.CrossRefPubMed
50.
Confino-Cohen R, Rosman Y, Meir-Shafrir K, Stauber T, Lachover-Roth I, Hershko A, Goldberg A. Oral challenge without skin testing safely excludes clinically significant delayed-onset penicillin hypersensitivity. J Allergy Clin Immunol Pract. 2017;5:669–75.CrossRefPubMed
51.
Romano A, Caubet JC. Antibiotic allergies in children and adults: from clinical symptoms to skin testing diagnosis. J Allergy Clin Immunol Pract. 2014;2:3–12.CrossRefPubMed
52.
Chiriac AM, Rerkpattanapipat T, Bousquet PJ, Molinari N, Demoly P. Optimal step doses for drug provocation tests to prove betalactam hypersensitivity. Allergy. 2017;72:552–61.CrossRefPubMed
53.
Torres MJ, Romano A, Celik G, Demoly P, Khan DA, Macy E, Park M, Blumenthal K, Aberer W, Castells M, Barbaud A, Mayorga C. Approach to the diagnosis of drug hypersensitivity reactions: similarities and differences between Europe and North America. Clin Transl Allergy. 2017;13(7):7.CrossRef
54.
Macy E. Pratical management of patients with an history of immediate hypersensitivity to common non beta lactam drugs. Curr Allergy Asthma Rep. 2016;16:4.CrossRefPubMed
55.
Blanca-López N, Zapatero L, Alonso E, Torres MJ, Fuentes V, Martínez-Molero MI, Blanca M. Skin testing and drug provocation in the diagnosis of non immediate reactions to aminopenicillins in children. Allergy. 2009;64:229–33.CrossRefPubMed
56.
Hjortlund J, Mortz CG, Skov PS, Bindslev-Jensen C. Diagnosis of penicillin allergy revisited: the value of case history, skin testing, specific IgE and prolonged challenge. Allergy. 2013;68:1057–64.CrossRefPubMed
57.
Mori F, Cianferoni A, Barni S, Pucci N, Rossi ME, Novembre E. Amoxicillin allergy in children: five-day drug provocation test in the diagnosis of non immediate reactions. J Allergy Clin Immunol Pract. 2015;3:375–380.e1.CrossRefPubMed
58.
Lezmi G, Alrowaishdi F, Bados-Albiero A, Scheinmann P, de Blic J, Ponvert C. Non-immediate-reading skin tests and prolonged challenges in non immediate hypersensitivity to beta-lactams in children. Pediatr Allergy Immunol. 2018;29:84–9.CrossRefPubMed
59.
Ratzon R, Reshef A, Efrati O, Deutch M, Forschmidt R, Cukierman- Yaffe T, Kenett R, Kidon MI. Impact of an extended challenge on the effectiveness of β-lactam hypersensitivity investigation. Ann Allergy Asthma Immunol. 2016;116:329–33.CrossRefPubMed
60.
Vezir E, Dibek Misirlioglu E, Civelek E, Capanoglu M, Guvenir H, Ginis T, Toyran M, Kocabas CN. Direct oral provocation tests in non-immediate mild cutaneous reactions related to beta-lactam antibiotics. Pediatr Allergy Immunol. 2016;27:50–4.CrossRefPubMed
61.
Ponvert C, Le CL, De BJ, Le BM, Scheinmann P, Paupe J. Allergy to beta-lactam antibiotics in children. Pediatrics. 1999;104:e45.CrossRefPubMed
62.
The Joint Task Force on Practice Parameters. Drug allergy: an updated practice parameters. Ann Allergy Asthma Immunol. 2010;105:259–73 e78.CrossRef
63.
Kuyucu S, Mori F, Atanaskovic-Markovich M, Caubet JC, Terrehorst I, Gomes E, Brockow K. Hypersensitivity reactions to non beta lactam antibiotics in children: an extensive review. Ped Allergy Immunol. 2014;25:534–43.
64.
Schnyder B, Pichler WJ. Allergy to sulfonamides: a review. JACI. 2013;131:256–7.
65.
Lin D, Li WIK, Rieder MJ. Cotrimoxazole for prophylaxis or treatment of opportunistic infections of HIV/AIDS in patients with previous history of hypersensitivity to cotrimoxazole. Cochrane Database Syst Rev:2007, CD005646.
66.
67.
Mori F, Barni S, Pucci N, et al. Sensivity and specificity of skin tests in the diagnosis of clarithromicin allergy. Ann Allergy Asthma Immunol. 2010;104:417–9.CrossRefPubMed
68.
Empedrad R, Darter AL, Earl HS, Gruchalla RS. Nonirritating intradermal skin test concentrations for commonly prescribed antibiotics. J Allergy Clin Immunol. 2003;112:629–30.CrossRefPubMed
69.
Broz P, Harr TH, Hecking C, Grize L, Scherer K, Jaeger KA, Bircher J. Non irritant intradermal skin test concentration of ciprofloxacin, clarithomycin, and rifampicin. Allergy. 2012;67:647–52.CrossRefPubMed
70.
Gomes ER, Fonseca J, Araujo L, Demoly P. Drug allergy in children: from self reporting to confirmed diagnosis. Clin Exp Allergy. 2008;38:191–8.
71.
Unal D, Semra D, Gelincik A, Olgac M, Coskun R, Colakoglu B, Buyukotzurk S. Diagnostic value of oral challenge testing in the diagnosis of macrolide hypersensitivity. J Allergy Clin Immunol Pract. 2018;6:521–52.CrossRefPubMed
72.
Lori DW, Behnam D. Desensitization protocols for vancomycin hypersensitivity. Ann Pharmacother. 2001;35:1458–64.CrossRef
73.
74.
Bensaid B, Rozieres A, Nosbaum A, Nicolas J, Berard F. Amikacin-induced drug reaction with eosinophilia and systemic symptoms syndrome: delayed skin test and ELISPOT assay results allow the identification of the culprit drug. J Allergy Clin Immunol. 2012;130:1413–4.CrossRefPubMed
75.
76.
Belloni Fortina A, Romano I, Peserico A, Eichenfield LF. Contact sensitization in very young children. J Am Acad Dermatol. 2011;65:772–9.CrossRefPubMed
77.
Cavkaytar O, Yilmaz EA, Karaatmaca B, et al. Different phenotypes of non steroidal anti inflammatory drug hypersensitivity during childhood. Int Arch Allergy Immunol. 2015;157:211–21.CrossRef
78.
Menéndez Ramos F, Liamas Martín R, Zarco Olivo C, Dorado Bris JM, merino Lugue MV. Allergic contact dermatitis from tobramycin. Contact Dermatitis. 1990;22:305–6.CrossRefPubMed
79.
Sanchez –BM, Thong B, Blanca M, et al. Hypersensitivity reactions to non beta lactam antimicrobial agents, a statement of the WAO special committee on drug allergy. World Allergy Org J. 2013;6:18.CrossRef
80.
Blanca Lopez N, Andreu I, Torres Jaen MJ. Hypesensitivity reactions to quinolones. Curr Opin Allergy Clin Immunol. 2011;11:285–91.CrossRefPubMed
81.
Rouzaire P, Nosbaum A, Mullet C, Diot N, Duborst R, Bienvenu F, Giulloux L, Piriou V, Bienvenu J, Berard F. Immediate allergic hypersensitivity to quinolones associates with neuro muscholar blocking agents. J Allergy Clin Immunol Pract. 2013;1:273–9.CrossRefPubMed
82.
Zambonino MA, Torres MJ, Munoz C, Requena G, Mayorga C, Posadas T, Urda A, Blanca M, Corzo JL. Drug provocation tests in the diagnosis of hypersensitivity reactions to non-steroidal anti-inflammatory drugs in children. Pediatr Allergy Immunol. 2013;24:151–9.CrossRefPubMed
83.
Alves C, Romeira AM, Abreu C, Carreiro-Martins P, Gomes E, Leiria-Pinto P. Non-steroidal anti-inflammatory drug hypersensitivity in children. Allergol Immunopathol (Madr). 2017;45:40–7.CrossRef
84.
Hassani A, Ponvert C, Karila C, Le Bourgeois M, De Blic J, Scheinmann P. Hypersensitivity to cyclooxygenase inhibitory drugs in children: a study of 164 cases. Eur J Dermatol. 2008;18:561–5.PubMed
85.
Kowalski ML, Asero R, Bavbek S, Blanca M, Blanca-Lopez N, Bochenek G, Brockow K, Campo P, Celik G, Cernadas J, Cortellini G, Gomes E, Niżankowska-Mogilnicka E, Romano A, Szczeklik A, Testi S, Torres MJ, Wöhrl S, Makowska J. Classification and practical approach to the diagnosis and management of hypersensitivity to nonsteroidal anti-inflammatory drugs. Allergy. 2013;68:1219–32.CrossRefPubMed
86.
Stevenson DD, Sanchez-Borges M, Szczeklik A. Classification of allergic and pseudoallergic reactions to drugs that inhibit cyclooxygenase enzymes. Ann Allergy Asthma Immunol. 2001;87:177–80.CrossRefPubMed
87.
Caimmi S, Caimmi D, Bousquet PJ, Demoly P. How can we better classify NSAID hypersensitivity reactions? Validation from a large database. Int Arch Allergy Immunol. 2012;159:306–12.CrossRefPubMed
88.
Defrance C, Bousquet P, Demoly P. Evaluating the negative predictive value of provocation tests with nonsteroidal ant-infiammatory drugs. Allergy. 2011;66:1410–4.CrossRefPubMed
89.
Alves C, Romeira AM, Abreu C, Carreiro Martins P, Gomes E, Leiria Pinto P. Non steroidal antinflammatory drug hypersensitivity. Allergol Immunopathol. 2017;45:40–7.CrossRef
90.
Canto GM, Andreu I, Fernandez J, Blanca M. Selective immediate hypersensitivity reactions to NSAIDs. Curr Opin Allergy Clin Immunol. 2009;9:293–7.CrossRefPubMed
91.
Marraccini P, Pignatti P, D Apos Alcamo A, Salimbeni R, Consonni D. Basophil activation test application in drug hypersensitivity diagnosis: an empirical approach. Int Arch Allergy Immunol 2018; 177: 160–166.
92.
Blanca-Lopez N, Perez-Alzate D, Canto G, Blanca M. Practical approach to the treatment of NSAID hypersensitivity. Expert Rev Clin Immunol. 2017;13:1017–27.CrossRefPubMed
93.
Kidon MI, Kang LW, Chin CW, Hoon LS, Hugo VB. Non steroidal anti inflammatory hypersensitivity in preschool children. Allergy Asthma Clin Immunol. 2007;3:114–22.PubMedPubMedCentral
94.
Blanca-Lopez N, Haron-diaz E, Ruano FJ, Perez-Azalte D, Somoza ML, Vasquez de la Torre Gaspar M, Rivas Riuz F, Garcia Martin E, Blanca M, Canto G. Acetyl salicylic challenge in children with hypersensitivity reactions to non steroidal anti inflammatory drugs differentiates between cross intolerant and selective responders. J Allergy Clin Immunol Pract. 2018;6:1226–35.CrossRefPubMed
95.
Caglayan Sozmen S, Povesi Dascola C, Mastrorilli C, Gioia E, Rizzuti L, Caffarelli C. Diagnostic accuracy of patch test in children with food allergy. Pediatr Allergy Immunol. 2015;26:416–22.CrossRefPubMed
96.
97.
Corradi M, Zinelli C, Caffarelli C. Exhaled breath biomarkers in asthmatic children. Inflamm Allergy Drug Targets. 2007;6:150–9.CrossRefPubMed
Metadata
Title
SIAIP position paper: provocation challenge to antibiotics and non-steroidal anti-inflammatory drugs in children
Authors
Carlo Caffarelli
Fabrizio Franceschini
Davide Caimmi
Francesca Mori
Lucia Diaferio
Dora Di Mauro
Carla Mastrorilli
Stefania Arasi
Simona Barni
Paolo Bottau
Silvia Caimmi
Fabio Cardinale
Pasquale Comberiati
Giuseppe Crisafulli
Lucia Liotti
Umberto Pelosi
Francesca Saretta
Gianluigi Marseglia
Marzia Duse
Francesco Paravati
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Italian Journal of Pediatrics / Issue 1/2018
Electronic ISSN: 1824-7288
DOI
https://doi.org/10.1186/s13052-018-0589-3

Other articles of this Issue 1/2018

Italian Journal of Pediatrics 1/2018 Go to the issue

Research

S737F is a new CFTR mutation typical of patients originally from the Tuscany region in Italy

Review

Male and undernourished children were at high risk of anemia in Ethiopia: a systematic review and meta-analysis

Research

ADHD prevalence estimates in Italian children and adolescents: a methodological issue

Research

Acute malnutrition among children aged 6–59 months of the nomadic population in Hadaleala district, Afar region, northeast Ethiopia

Case report

Common symptoms for a rare disease in a girl with sarcoidosis: a case report

Review

Low birth weight and its associated factors in Ethiopia: a systematic review and meta-analysis