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Clinical and Translational Allergy
Published in: Clinical and Translational Allergy 1/2017

Open Access 01-12-2017 | Review

Approach to the diagnosis of drug hypersensitivity reactions: similarities and differences between Europe and North America

Authors: M. J. Torres, A. Romano, G. Celik, P. Demoly, D. A. Khan, E. Macy, M. Park, K. Blumenthal, W. Aberer, M. Castells, A. Barbaud, C. Mayorga, P. Bonadonna

Published in: Clinical and Translational Allergy | Issue 1/2017

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Abstract

Drug hypersensitivity reactions (DHRs) affect an unknown proportion of the general population, and are an important public health problem due to their potential to cause life-threatening anaphylaxis and rare severe cutaneous allergic reactions. DHR evaluations are frequently needed in both ambulatory and hospital settings and have a complex diagnosis that requires a detailed clinical history and other tests that may include in vitro tests and in vivo procedures such as skin tests and drug provocation tests. Although over the years both European and U.S. experts have published statements on general procedures for evaluating DHRs, a substantial discordance in their daily management exists. In this review, we highlight both the differences and the similarities between the European and U.S. perspectives. While a general consensus exists on the importance of skin tests for evaluating DHRs, concordance between Americans and Europeans exists solely regarding their use in immediate reactions and the fact that a confirmation of a presumptive diagnosis by drug provocation tests is often the only reliable way to establish a diagnosis. Finally, great heterogeneity exists in the application of in vitro tests, which require further study to be well validated.
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Metadata
Title
Approach to the diagnosis of drug hypersensitivity reactions: similarities and differences between Europe and North America
Authors
M. J. Torres
A. Romano
G. Celik
P. Demoly
D. A. Khan
E. Macy
M. Park
K. Blumenthal
W. Aberer
M. Castells
A. Barbaud
C. Mayorga
P. Bonadonna
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Clinical and Translational Allergy / Issue 1/2017
Electronic ISSN: 2045-7022
DOI
https://doi.org/10.1186/s13601-017-0144-0

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