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Open Access 01-12-2018 | Letter to the Editor

Detection of IL10-producing B cell (B10) in adenoids of atopic children with adenoidal hypertrophy

Authors: Chiara Valsecchi, Sara Carlotta Tagliacarne, Ilaria Brambilla, Catherine Klersy, Marco Benazzo, Lorenza Montagna, Dimitri Poddighe, Giorgio Ciprandi, Gian Luigi Marseglia, Amelia Licari, Annamaria Castellazzi

Published in: Italian Journal of Pediatrics | Issue 1/2018

Excerpt

Regulatory cells are important for maintaining immunological homeostasis and tolerance to antigens, including self-antigens. Even though in the majority of autoimmune diseases and inflammatory processes, B cells generally play an important role due to their capacity to secrete antibodies, it has emerged that different B cell subsets may be able to down regulate immune responses, especially in experimental autoimmune disease models. Moreover, it has been demonstrated that B cells are able to drive T cell differentiation in favor of a regulatory phenotype (regulatory T cells, Treg) both in mice and humans [1]. …

Kalampokis I, Yoshizaki A, Tedder TF. IL-10-producing regulatory B cells (B10 cells) in autoimmune disease. Arthritis Res Ther. 2013;15(Suppl 1):S1.CrossRefPubMedPubMedCentral

Jin G, Hamaguchi Y, Matsushita T, Hasegawa M, Le Huu D, Ishiura N, Naka K, et al. B cell linker protein expression contributes to controlling allergic and autoimmune diseases by mediating IL-10 production in regulatory B cells. J Allergy Clin Immunol. 2013;131:1674–82.CrossRefPubMed

Annunziato F, Romagnani C, Romagnani S. The 3 major types of innate and adaptive cell-mediated effector immunity. J Allergy Clin Immunol. 2015;135(3):626–35.CrossRefPubMed

Palomares O, Akdis M, Martín-Fontecha M, Akdis CA. Mechanisms of immune regulation in allergic diseases: the role of regulatory T and B cells. Immunol Rev. 2017;278(1):219–36.CrossRefPubMed

Schussler E, Sobel J, Hsu J, Yu P, Meaney-Delman D, Grammer LC 3rd, Nowak-Wegrzyn A. Workgroup report by the joint task force involving American Academy of Allergy, Asthma & Immunology (AAAAI); food allergy, anaphylaxis, dermatology and drug allergy (FADDA) (adverse reactions to foods committee and adverse reactions to drugs, biologicals, and latex committee); and the Centers for Disease Control and Prevention botulism clinical treatment guidelines workgroup-allergic reactions to botulinum antitoxin: a systematic review. Clin Infect Dis 2017; 66(suppl_1):S65-S72.

Tagliacarne SC, Valsecchi C, Castellazzi AM, Licari A, Klersy C, Montagna L, Castagnoli R, Benazzo M, Ciprandi G, Marseglia GL. Impact of passive smoke and/or atopy on adenoid immunoglobulin production in children. Immunol Lett. 2015;165(2):70–7.CrossRefPubMed

Iwata Y, Matsushita T, Horikawa M, Dilillo DJ, Yanaba K, Venturi GM, Szabolcs PM, Bernstein SH, Magro CM, Williams AD, Hall RP, St Clair EW, Tedder TF. Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells. Blood. 2011;117(2):530–41.CrossRefPubMedPubMedCentral

Kim AS, Doherty TA, Karta MR, Das S, Baum R, Rosenthal P, Beppu A, Miller M, Kurten R, Broide DH. Regulatory B cells and T follicular helper cells are reduced in allergic rhinitis. J Allergy Clin Immunol. 2016;138(4):1192–1195.e5.CrossRefPubMedPubMedCentral

Israel E, Kapelushnik J, Yermiahu T, Levi I, Yaniv I, Shpilberg O, Shubinsky G. Expression of CD24 on CD19- CD79a+ early B-cell progenitors in human bone marrow. Cell Immunol. 2005;236(1–2):171–8.CrossRefPubMed

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Komlósi ZI, Kovács N, van de Veen W, Kirsch A, Fahrner HB, Wawrzyniak M, Rebane A, Stanic B, Palomares O, Rückert B, Menz G, Akdis M, Losonczy G, Akdis CA. Human CD40L-expressing type 3 innate lymphoid cells induce IL-10-producing immature transitional regulatory B cells. J Allergy Clin Immunol. 2017;S0091-6749(17):31460–4.

Title: Detection of IL10-producing B cell (B10) in adenoids of atopic children with adenoidal hypertrophy
Authors: Chiara Valsecchi
Sara Carlotta Tagliacarne
Ilaria Brambilla
Catherine Klersy
Marco Benazzo
Lorenza Montagna
Dimitri Poddighe
Giorgio Ciprandi
Gian Luigi Marseglia
Amelia Licari
Annamaria Castellazzi
Publication date: 01-12-2018
Publisher: BioMed Central
Published in: Italian Journal of Pediatrics / Issue 1/2018
Electronic ISSN: 1824-7288
DOI: https://doi.org/10.1186/s13052-018-0471-3

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Detection of IL10-producing B cell (B10) in adenoids of atopic children with adenoidal hypertrophy

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Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

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