Skip to main content
Top
Published in: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 1/2017

Open Access 01-12-2017 | Original research

Barriers and facilitators towards implementing the Sepsis Six care bundle (BLISS-1): a mixed methods investigation using the theoretical domains framework

Authors: Neil Roberts, Guy Hooper, Fabiana Lorencatto, Wendell Storr, Michael Spivey

Published in: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine | Issue 1/2017

Login to get access

Abstract

Background

The ‘Sepsis 6’, a care bundle of basic, but vital, measures (e.g. intravenous fluid, antibiotics) has been implemented to improve sepsis treatment. However, uptake has been variable. Tools from behavioral sciences, such as the Theoretical Domains Framework (TDF) may be used to understand and address such implementation issues. This study used a behavioral science approach to identify barriers and facilitators towards Sepsis Six implementation at a case study hospital.

Methods

Semi-structured interviews based on the TDF were conducted with a sample group of consultants, junior doctors and nurses from Emergency Department, Medical and Surgical Admissions, to explore barriers/facilitators to Sepsis Six performance. Transcripts were analyzed following the combined principles of content and framework analysis. Emerging themes informed a questionnaire to explore generalizability and importance across a sample of 261 stakeholders. Median importance and agreement ratings for each theme were calculated overall and for each role and clinical area. These were used to identify important barriers and important facilitators as targets for performance improvement.

Results

No new belief statements were discovered and data saturation was deemed achieved after 10 interviews. 1699 utterances were coded into 64 belief statements, then collated into a 51-item questionnaire. 113 questionnaire responses were obtained (44.3% response rate). Important barriers included insufficient audit and feedback, poor teamwork and communication, concerns about using the Sepsis Six in certain patients, insufficient training, and resource concerns. Facilitators included confidence in knowledge and skills, beliefs in overall benefits of the bundle, beliefs that identification and management of septic patients fell within everyone’s role, and that regular use of the bundle made it easier to remember. Some beliefs were applicable for the entire group, others were specific to particular staff groups.

Discussion and Conclusions

A range of barriers and facilitators towards Sepsis Six performance across different staff groups were systematically identified using a theoretically-informed approach. This can inform development of targeted performance improvement interventions.
Appendix
Available only for authorised users
Literature
1.
go back to reference Singer M, Deutschman C, Seymour C, Shankar-Hari M, Annane D, Bauer M, et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016;315(8):801–10.CrossRefPubMedPubMedCentral Singer M, Deutschman C, Seymour C, Shankar-Hari M, Annane D, Bauer M, et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016;315(8):801–10.CrossRefPubMedPubMedCentral
3.
go back to reference Rivers E, Nguyen B, Havstad S, et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med. 2001;345:1368–77.CrossRefPubMed Rivers E, Nguyen B, Havstad S, et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med. 2001;345:1368–77.CrossRefPubMed
4.
go back to reference Kaukonen KM, Bailey M, Suzuki S, Pilcher D, Bellomo R. Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000-2012. JAMA. 2014;311:1308–16.CrossRefPubMed Kaukonen KM, Bailey M, Suzuki S, Pilcher D, Bellomo R. Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000-2012. JAMA. 2014;311:1308–16.CrossRefPubMed
5.
6.
go back to reference The ARISE Investigators and the ANZICS Clinical Trials Group. Goal-directed resuscitation for patients with early septic shock. N Engl J Med. 2014;371:1496–506.CrossRef The ARISE Investigators and the ANZICS Clinical Trials Group. Goal-directed resuscitation for patients with early septic shock. N Engl J Med. 2014;371:1496–506.CrossRef
7.
go back to reference The ProMISe Trial Investigators. Trial of early, goal-directed resuscitation for septic shock. N Engl J Med. 2015;372:1301–11.CrossRef The ProMISe Trial Investigators. Trial of early, goal-directed resuscitation for septic shock. N Engl J Med. 2015;372:1301–11.CrossRef
8.
go back to reference Cronshaw HL. Impact of the surviving sepsis campaign on the recognition and management of severe sepsis in the emergency department: are we failing? Emerg Med J. 2011;28:670–5.CrossRefPubMed Cronshaw HL. Impact of the surviving sepsis campaign on the recognition and management of severe sepsis in the emergency department: are we failing? Emerg Med J. 2011;28:670–5.CrossRefPubMed
10.
go back to reference Kuo J, Chang H, Wu P, et al. Compliance and barriers to implementing the sepsis resuscitation bundle for patients developing septic shock in the general medical wards. J Formos Med Assoc. 2012;111:77–82.CrossRefPubMed Kuo J, Chang H, Wu P, et al. Compliance and barriers to implementing the sepsis resuscitation bundle for patients developing septic shock in the general medical wards. J Formos Med Assoc. 2012;111:77–82.CrossRefPubMed
11.
go back to reference Daniels R, Nutbeam T, McNamara G, Galvin C. The sepsis six and the severe sepsis resuscitation bundle: a prospective observational cohort study. Emerg Med J. 2011;28:507–12.CrossRefPubMed Daniels R, Nutbeam T, McNamara G, Galvin C. The sepsis six and the severe sepsis resuscitation bundle: a prospective observational cohort study. Emerg Med J. 2011;28:507–12.CrossRefPubMed
12.
go back to reference Tarrant C, O’Donnell B, Martin G, et al. A complex endeavour: an ethnographic study of the implementation of the sepsis six clinical care bundle. Implementation Sci. 2016;11:149.CrossRef Tarrant C, O’Donnell B, Martin G, et al. A complex endeavour: an ethnographic study of the implementation of the sepsis six clinical care bundle. Implementation Sci. 2016;11:149.CrossRef
13.
go back to reference Charani E. E. Castro-Sanchez, N. Sevdalis, Y. Kyratsis, L. Drumright, N. Shah, and A. Holmes. "Understanding the determinants of antimicrobial prescribing within hospitals: the role of “prescribing etiquette”.". Clin Infect Dis. 2013;57(2):188–96.CrossRefPubMedPubMedCentral Charani E. E. Castro-Sanchez, N. Sevdalis, Y. Kyratsis, L. Drumright, N. Shah, and A. Holmes. "Understanding the determinants of antimicrobial prescribing within hospitals: the role of “prescribing etiquette”.". Clin Infect Dis. 2013;57(2):188–96.CrossRefPubMedPubMedCentral
14.
go back to reference Davey P, et al. Time for action—improving the design and reporting of behavior change interventions for antimicrobial stewardship in hospitals: early findings from a systematic review. Int J Antimicrob Agents. 2015;45(3):203–12.CrossRefPubMed Davey P, et al. Time for action—improving the design and reporting of behavior change interventions for antimicrobial stewardship in hospitals: early findings from a systematic review. Int J Antimicrob Agents. 2015;45(3):203–12.CrossRefPubMed
15.
go back to reference Tavender EJ, Bosch M, Fiander M, Knott JC, Gruen RL, O’Connor D. Implementation research in emergency medicine: a systematic scoping review. EMJ 2015;(ePublished ahead of print). Tavender EJ, Bosch M, Fiander M, Knott JC, Gruen RL, O’Connor D. Implementation research in emergency medicine: a systematic scoping review. EMJ 2015;(ePublished ahead of print).
16.
go back to reference Charani E, Edwards R, Sevdalis N, Alexandrou B, Sibley E, Mullett D, Franklin B, et al. Behavior change strategies to influence antimicrobial prescribing in acute care: a systematic review. Clin Infect Dis. 2011;53(7):651–62.CrossRefPubMed Charani E, Edwards R, Sevdalis N, Alexandrou B, Sibley E, Mullett D, Franklin B, et al. Behavior change strategies to influence antimicrobial prescribing in acute care: a systematic review. Clin Infect Dis. 2011;53(7):651–62.CrossRefPubMed
17.
go back to reference Eccles M, Grimshaw J, Walker A, et al. Changing the behavior of healthcare professionals: the use of theory in promoting the uptake of research findings. J Clin Epidemiol. 2005;58(2):107–12.CrossRefPubMed Eccles M, Grimshaw J, Walker A, et al. Changing the behavior of healthcare professionals: the use of theory in promoting the uptake of research findings. J Clin Epidemiol. 2005;58(2):107–12.CrossRefPubMed
18.
go back to reference Michie S, Prestwich A. Are interventions theory-based? Development of a theory coding scheme. Health Psych. 2010;29(1):1.CrossRef Michie S, Prestwich A. Are interventions theory-based? Development of a theory coding scheme. Health Psych. 2010;29(1):1.CrossRef
20.
go back to reference Cane J, O’Connor D, Michie S. Validation of the theoretical domains framework for use in behavior change and implementation research. Implement Sci. 2012;7:37.CrossRefPubMedPubMedCentral Cane J, O’Connor D, Michie S. Validation of the theoretical domains framework for use in behavior change and implementation research. Implement Sci. 2012;7:37.CrossRefPubMedPubMedCentral
21.
go back to reference Francis JJ, O’Connor D, Curran J. Theories of behavior change synthesised into a set of theoretical groupings: introducing a thematic series on the theoretical domains framework. Implement Sci. 2012;7:35.CrossRefPubMedPubMedCentral Francis JJ, O’Connor D, Curran J. Theories of behavior change synthesised into a set of theoretical groupings: introducing a thematic series on the theoretical domains framework. Implement Sci. 2012;7:35.CrossRefPubMedPubMedCentral
22.
go back to reference Cuthbertson BH, Campbell MK, MacLennan G, et al. Clinical stakeholders’ opinions on the use of selective decontamination of the digestive tract in critically ill patients in intensive care units: an international Delphi study. Crit Care. 2013;17:R266.CrossRefPubMedPubMedCentral Cuthbertson BH, Campbell MK, MacLennan G, et al. Clinical stakeholders’ opinions on the use of selective decontamination of the digestive tract in critically ill patients in intensive care units: an international Delphi study. Crit Care. 2013;17:R266.CrossRefPubMedPubMedCentral
23.
go back to reference Gould NJ, Lorencatto F, Stanworth SJ, Michie S, Prior ME, Glidewell L, et al. Application of theory to enhance audit and feedback interventions to increase the uptake of evidence-based transfusion practice: an intervention development protocol. Implement Sci. 2014;9(1):92.CrossRefPubMedPubMedCentral Gould NJ, Lorencatto F, Stanworth SJ, Michie S, Prior ME, Glidewell L, et al. Application of theory to enhance audit and feedback interventions to increase the uptake of evidence-based transfusion practice: an intervention development protocol. Implement Sci. 2014;9(1):92.CrossRefPubMedPubMedCentral
24.
go back to reference Roberts N, Lorencatto F, Manson J, Brundage S, Jansen J. What helps or hinders the transformation from a major tertiary center to a major trauma center? Identifying barriers and enablers using the Theoretical Domains Framework. Scand J Trauma Resusc Emerge Med. 2016;24:30.CrossRef Roberts N, Lorencatto F, Manson J, Brundage S, Jansen J. What helps or hinders the transformation from a major tertiary center to a major trauma center? Identifying barriers and enablers using the Theoretical Domains Framework. Scand J Trauma Resusc Emerge Med. 2016;24:30.CrossRef
25.
go back to reference Cane J, Richardson M, Johnston M, et al. From lists of behavior change techniques (BCTs) to structured hierarchies: comparison of two methods of developing a hierarchy of BCTs. British J Health Psych. 2015;20(1):130–50.CrossRef Cane J, Richardson M, Johnston M, et al. From lists of behavior change techniques (BCTs) to structured hierarchies: comparison of two methods of developing a hierarchy of BCTs. British J Health Psych. 2015;20(1):130–50.CrossRef
26.
go back to reference Michie S, Johnston M, Francis J, et al. From theory to intervention: mapping theoretically derived behavioral determinants to behavior change techniques. Appl Psychol. 2008;57(4):660–80.CrossRef Michie S, Johnston M, Francis J, et al. From theory to intervention: mapping theoretically derived behavioral determinants to behavior change techniques. Appl Psychol. 2008;57(4):660–80.CrossRef
27.
go back to reference Steinmo S, Fuller C, Stone S, Michie S. Characterising an implementation intervention in terms of behavior change techniques and theory: the ‘sepsis six’ clinical care bundle. Implement Sci. 2015;10:111.CrossRefPubMedPubMedCentral Steinmo S, Fuller C, Stone S, Michie S. Characterising an implementation intervention in terms of behavior change techniques and theory: the ‘sepsis six’ clinical care bundle. Implement Sci. 2015;10:111.CrossRefPubMedPubMedCentral
28.
go back to reference Steinmo S, Michie S, Fuller C, Stanley S, Stapleton C, Stone S. Bridging the gap between pragmatic intervention design and theory: using behavioral science tools to modify an existing quality improvement programme to implement “sepsis six”. Implement Sci. 2016;11:14.CrossRefPubMedPubMedCentral Steinmo S, Michie S, Fuller C, Stanley S, Stapleton C, Stone S. Bridging the gap between pragmatic intervention design and theory: using behavioral science tools to modify an existing quality improvement programme to implement “sepsis six”. Implement Sci. 2016;11:14.CrossRefPubMedPubMedCentral
29.
go back to reference Personal communication, J Stratton, Governance Lead for Medicine, Royal Cornwall Hospital, 2015. Personal communication, J Stratton, Governance Lead for Medicine, Royal Cornwall Hospital, 2015.
30.
go back to reference Francis JJ, Johnston M, Robertson C, et al. What is an adequate sample size? Operationalising data saturation for theory-based interview studies. Psychol Health. 2010;25:1229–45.CrossRefPubMed Francis JJ, Johnston M, Robertson C, et al. What is an adequate sample size? Operationalising data saturation for theory-based interview studies. Psychol Health. 2010;25:1229–45.CrossRefPubMed
31.
go back to reference McSherry LA, Dombrowski SU, Francis JJ, et al. ‘It’s a can of worms’: understanding primary care practitioners’ behaviors in relation to HPV using the theoretical domains framework. Implement Sci. 2012;7(1):73.CrossRefPubMedPubMedCentral McSherry LA, Dombrowski SU, Francis JJ, et al. ‘It’s a can of worms’: understanding primary care practitioners’ behaviors in relation to HPV using the theoretical domains framework. Implement Sci. 2012;7(1):73.CrossRefPubMedPubMedCentral
33.
go back to reference Ritchie J, Lewis J. Qualitative research practice. London: Sage publications; 2003. Ritchie J, Lewis J. Qualitative research practice. London: Sage publications; 2003.
34.
go back to reference Duncan EM, Francis JJ, Johnston M, et al. Learning curves, taking instructions, and patient safety: using a theoretical domains framework in an interview study to investigate prescribing errors among trainee doctors. Implement Sci. 2012;7(1):86.CrossRefPubMedPubMedCentral Duncan EM, Francis JJ, Johnston M, et al. Learning curves, taking instructions, and patient safety: using a theoretical domains framework in an interview study to investigate prescribing errors among trainee doctors. Implement Sci. 2012;7(1):86.CrossRefPubMedPubMedCentral
35.
go back to reference Curran JA, Brehaut J, Patey AM, Osmond M, et al. Understanding the Canadian adult CT head rule trial: use of the theoretical domains framework for process evaluation. Implement Sci. 2013;8(25):10. Curran JA, Brehaut J, Patey AM, Osmond M, et al. Understanding the Canadian adult CT head rule trial: use of the theoretical domains framework for process evaluation. Implement Sci. 2013;8(25):10.
36.
go back to reference Islam R, Tinmouth AT, Francis JJ, et al. A cross-country comparison of intensive care physicians’ beliefs about their transfusion behavior: a qualitative study using the theoretical domains framework. Implement Sci. 2012;7(1):93.CrossRefPubMedPubMedCentral Islam R, Tinmouth AT, Francis JJ, et al. A cross-country comparison of intensive care physicians’ beliefs about their transfusion behavior: a qualitative study using the theoretical domains framework. Implement Sci. 2012;7(1):93.CrossRefPubMedPubMedCentral
37.
go back to reference Bussieres AE, Patey AM, Francis JJ, et al. Identifying factors likely to influence compliance with diagnostic imaging guideline recommendations for spine disorders among chiropractors in North America: a focus group study using the theoretical domains framework. Implement Sci. 2012;7:82.CrossRefPubMedPubMedCentral Bussieres AE, Patey AM, Francis JJ, et al. Identifying factors likely to influence compliance with diagnostic imaging guideline recommendations for spine disorders among chiropractors in North America: a focus group study using the theoretical domains framework. Implement Sci. 2012;7:82.CrossRefPubMedPubMedCentral
38.
go back to reference Beenstock J, Sniehotta F, White M, Bell R, Milne E, Araujo-Soares V. What helps and hinders midwives in engaging with pregnant women about stopping smoking? A cross-sectional survey of perceived implementation difficulties among midwives in the North East of England. Implementation Sci. 2012;7:36.CrossRef Beenstock J, Sniehotta F, White M, Bell R, Milne E, Araujo-Soares V. What helps and hinders midwives in engaging with pregnant women about stopping smoking? A cross-sectional survey of perceived implementation difficulties among midwives in the North East of England. Implementation Sci. 2012;7:36.CrossRef
Metadata
Title
Barriers and facilitators towards implementing the Sepsis Six care bundle (BLISS-1): a mixed methods investigation using the theoretical domains framework
Authors
Neil Roberts
Guy Hooper
Fabiana Lorencatto
Wendell Storr
Michael Spivey
Publication date
01-12-2017
Publisher
BioMed Central
DOI
https://doi.org/10.1186/s13049-017-0437-2

Other articles of this Issue 1/2017

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 1/2017 Go to the issue