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Journal of Ovarian Research
Published in: Journal of Ovarian Research 1/2017

Open Access 01-12-2017 | Review

The role of Notch signalling in ovarian angiogenesis

Authors: Qi Xie, Zuowang Cheng, Xiaocui Chen, Corrinne G. Lobe, Ju Liu

Published in: Journal of Ovarian Research | Issue 1/2017

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Abstract

In adults, the ovary is characterized with extensive angiogenesis and regular intervals of rapid growth. Ovarian function is dependent on the network of angiogenic vessels which enable the follicle and/or corpus luteum to receive oxygen, nutrients and hormonal support. Abnormal angiogenesis is involved in the induction and development of pathological ovary, such as polycystic ovary syndrome and ovarian cancer. Notch signalling pathway is one of the primary regulators of angiogenesis and a therapeutic target for ovarian diseases. Here, we will review literatures on the expression pattern of Notch pathway components in the ovary and on the role of Notch signalling pathway on ovarian angiogenesis.
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Metadata
Title
The role of Notch signalling in ovarian angiogenesis
Authors
Qi Xie
Zuowang Cheng
Xiaocui Chen
Corrinne G. Lobe
Ju Liu
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Journal of Ovarian Research / Issue 1/2017
Electronic ISSN: 1757-2215
DOI
https://doi.org/10.1186/s13048-017-0308-5

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