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Published in: Journal of Experimental & Clinical Cancer Research 1/2020

Open Access 01-12-2020 | Hepatocellular Carcinoma | Review

Emerging roles and the regulation of aerobic glycolysis in hepatocellular carcinoma

Authors: Jiao Feng, Jingjing Li, Liwei Wu, Qiang Yu, Jie Ji, Jianye Wu, Weiqi Dai, Chuanyong Guo

Published in: Journal of Experimental & Clinical Cancer Research | Issue 1/2020

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Abstract

Liver cancer has become the sixth most diagnosed cancer and the fourth leading cause of cancer death worldwide. Hepatocellular carcinoma (HCC) is responsible for up to 75–85% of primary liver cancers, and sorafenib is the first targeted drug for advanced HCC treatment. However, sorafenib resistance is common because of the resultant enhancement of aerobic glycolysis and other molecular mechanisms. Aerobic glycolysis was firstly found in HCC, acts as a hallmark of liver cancer and is responsible for the regulation of proliferation, immune evasion, invasion, metastasis, angiogenesis, and drug resistance in HCC. The three rate-limiting enzymes in the glycolytic pathway, including hexokinase 2 (HK2), phosphofructokinase 1 (PFK1), and pyruvate kinases type M2 (PKM2) play an important role in the regulation of aerobic glycolysis in HCC and can be regulated by many mechanisms, such as the AMPK, PI3K/Akt pathway, HIF-1α, c-Myc and noncoding RNAs. Because of the importance of aerobic glycolysis in the progression of HCC, targeting key factors in its pathway such as the inhibition of HK2, PFK or PKM2, represent potential new therapeutic approaches for the treatment of HCC.
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Metadata
Title
Emerging roles and the regulation of aerobic glycolysis in hepatocellular carcinoma
Authors
Jiao Feng
Jingjing Li
Liwei Wu
Qiang Yu
Jie Ji
Jianye Wu
Weiqi Dai
Chuanyong Guo
Publication date
01-12-2020
Publisher
BioMed Central
Published in
Journal of Experimental & Clinical Cancer Research / Issue 1/2020
Electronic ISSN: 1756-9966
DOI
https://doi.org/10.1186/s13046-020-01629-4

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