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Journal of Experimental & Clinical Cancer Research

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Open Access 01-12-2015 | Research

High expression of DDR1 is associated with the poor prognosis in Chinese patients with pancreatic ductal adenocarcinoma

Authors: Yanmiao Huo, Minwei Yang, Wei Liu, Jianyu Yang, Xueliang Fu, Dejun Liu, Jiao Li, Junfeng Zhang, Rong Hua, Yongwei Sun

Published in: Journal of Experimental & Clinical Cancer Research | Issue 1/2015

Abstract

Background

Discoidin domain receptors 1 (DDR1), a subtype of DDRs, has been reported as a critical modulator of cellular morphogenesis, differentiation, migration and invasion.

Methods and results

In this study, we investigated the expression of DDR1 and its clinical association in Chinese patients with pancreatic ductal adenocarcinoma (PDAC). Across a cohort of 30 patients, we examined DDR1 expression in paired PDAC and corresponding adjacent non-tumor tissues by real-time quantitative PCR (RT-qPCR), or western blotting. DDR1 expression is significantly higher in PDAC, as compared to normal adjacent tissue, confirming results from the Oncomine databases. We validated DDR1 expression by immunohistochemistry across a non-overlapping cohort of 205 PDAC specimens. Kaplan-Meier survival curves indicate that increased expression of DDR1 is associated with a poor prognosis in PDAC patients (P = 0.013). Multivariate Cox regression analysis identified DDR1 expression, age, N classification and liver metastasis as independent prognostic factors in PDAC.

Conclusions

This study demonstrated that DDR1 can well serve as a novel prognostic biomarker in PDAC.

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Title: High expression of DDR1 is associated with the poor prognosis in Chinese patients with pancreatic ductal adenocarcinoma
Authors: Yanmiao Huo
Minwei Yang
Wei Liu
Jianyu Yang
Xueliang Fu
Dejun Liu
Jiao Li
Junfeng Zhang
Rong Hua
Yongwei Sun
Publication date: 01-12-2015
Publisher: BioMed Central
Published in: Journal of Experimental & Clinical Cancer Research / Issue 1/2015
Electronic ISSN: 1756-9966
DOI: https://doi.org/10.1186/s13046-015-0202-1

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Abstract

Background

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Conclusions

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