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Journal of Hematology & Oncology
Published in: Journal of Hematology & Oncology 1/2021

01-12-2021 | Lymphoma | Review

Targeting the tumor microenvironment in B-cell lymphoma: challenges and opportunities

Authors: Yingyue Liu, Xiangxiang Zhou, Xin Wang

Published in: Journal of Hematology & Oncology | Issue 1/2021

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Abstract

B-cell lymphoma is a group of hematological malignancies with high clinical and biological heterogeneity. The pathogenesis of B-cell lymphoma involves a complex interaction between tumor cells and the tumor microenvironment (TME), which is composed of stromal cells and extracellular matrix. Although the roles of the TME have not been fully elucidated, accumulating evidence implies that TME is closely relevant to the origination, invasion and metastasis of B-cell lymphoma. Explorations of the TME provide distinctive insights for cancer therapy. Here, we epitomize the recent advances of TME in B-cell lymphoma and discuss its function in tumor progression and immune escape. In addition, the potential clinical value of targeting TME in B-cell lymphoma is highlighted, which is expected to pave the way for novel therapeutic strategies.
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Metadata
Title
Targeting the tumor microenvironment in B-cell lymphoma: challenges and opportunities
Authors
Yingyue Liu
Xiangxiang Zhou
Xin Wang
Publication date
01-12-2021
Publisher
BioMed Central
Published in
Journal of Hematology & Oncology / Issue 1/2021
Electronic ISSN: 1756-8722
DOI
https://doi.org/10.1186/s13045-021-01134-x

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