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Journal of Hematology & Oncology
Published in: Journal of Hematology & Oncology 1/2020

01-12-2020 | Ovarian Cancer | Review

High-throughput approaches for precision medicine in high-grade serous ovarian cancer

Authors: Meinusha Govindarajan, Christoph Wohlmuth, Matthew Waas, Marcus Q. Bernardini, Thomas Kislinger

Published in: Journal of Hematology & Oncology | Issue 1/2020

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Abstract

High-grade serous carcinoma (HGSC) is the most prevalent and aggressive subtype of ovarian cancer. The large degree of clinical heterogeneity within HGSC has justified deviations from the traditional one-size-fits-all clinical management approach. However, the majority of HGSC patients still relapse with chemo-resistant cancer and eventually succumb to their disease, evidence that further work is needed to improve patient outcomes. Advancements in high-throughput technologies have enabled novel insights into biological complexity, offering a large potential for informing precision medicine efforts. Here, we review the current landscape of clinical management for HGSC and highlight applications of high-throughput biological approaches for molecular subtyping and the discovery of putative blood-based biomarkers and novel therapeutic targets. Additionally, we present recent improvements in model systems and discuss how their intersection with high-throughput platforms and technological advancements is positioned to accelerate the realization of precision medicine in HGSC.
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Metadata
Title
High-throughput approaches for precision medicine in high-grade serous ovarian cancer
Authors
Meinusha Govindarajan
Christoph Wohlmuth
Matthew Waas
Marcus Q. Bernardini
Thomas Kislinger
Publication date
01-12-2020
Publisher
BioMed Central
Published in
Journal of Hematology & Oncology / Issue 1/2020
Electronic ISSN: 1756-8722
DOI
https://doi.org/10.1186/s13045-020-00971-6

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