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Journal of Hematology & Oncology
Published in: Journal of Hematology & Oncology 1/2015

Open Access 01-12-2015 | Review

The roles of stem cell memory T cells in hematological malignancies

Authors: Ling Xu, Yikai Zhang, Gengxin Luo, Yangqiu Li

Published in: Journal of Hematology & Oncology | Issue 1/2015

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Abstract

Adoptive cell therapy (ACT) is rapidly migrating from bench to clinical therapy for hematological malignancies. Recently, a new subtype of memory T cells, stem cell memory T (TSCM) cells, was shown to be one of the most favorable subsets for ACT. TSCM has high self-renewal capacity and is associated with superior T cell engraftment, persistence, and antitumor immunity. In this review, we focused on the characteristics of antigen-specific TSCM cells and discussed their potential for immunotherapy targeting hematological malignancies.
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Metadata
Title
The roles of stem cell memory T cells in hematological malignancies
Authors
Ling Xu
Yikai Zhang
Gengxin Luo
Yangqiu Li
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Journal of Hematology & Oncology / Issue 1/2015
Electronic ISSN: 1756-8722
DOI
https://doi.org/10.1186/s13045-015-0214-5

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