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Annals of Hematology
Published in: Annals of Hematology 1/2012

01-01-2012 | Original Article

Immune response as a possible mechanism of long-lasting disease control in spontaneous remission of MLL/AF9-positive acute myeloid leukemia

Authors: Claudia Müller-Schmah, Leticia Solari, Roland Weis, Dietmar Pfeifer, Carmen Scheibenbogen, Martin Trepel, Annette M. May, Rupert Engelhardt, Michael Lübbert

Published in: Annals of Hematology | Issue 1/2012

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Abstract

Spontaneous complete remission (CR) is a rare, poorly understood phenomenon in acute myeloid leukemia (AML). We describe the 10-year follow-up of a patient with MLL-AF9-positive AML (Müller et al. Eur J Haematol 73:62–66, 2004), including ex vivo antileukemic immune responses which may contribute to the long-lasting spontaneous CR (tantamount to cure). We could demonstrate strong in vitro cytotoxic activity mediated by the patient’s serum (cryopreserved at diagnosis 2001) against myeloid cell lines. We also addressed cellular cytotoxic activity against myeloid leukemia cells. When the patient’s natural killer (NK) cells (obtained in 2007) were tested against the K562 cell line, upregulation of CD107 occurred, implying that long-term CR in this patient could be due to NK cell-mediated disease control.
Literature
1.
Müller CI, Trepel M, Kunzmann R, Lais A, Engelhardt R, Lübbert M (2004) Hematologic and molecular spontaneous remission following sepsis in acute monoblastic leukemia with translocation (9;11): a case report and review of the literature. Eur J Haematol 73:62–66PubMedCrossRef
2.
Fozza C, Bellizzi S, Bonfigli S, Campus PM, Dore F, Longinotti M (2004) Cytogenetic and hematological spontaneous remission in a case of acute myelogenous leukemia. Eur J Haematol 73:219–222PubMedCrossRef
3.
Mitterbauer M, Fritzer-Szekeres M, Mitterbauer G, Simonitsch I, Knöbl P, Rintelen C, Schwarzinger I, Haas OA, Silberbauer K, Frey K, Bibus B, Pabinger I, Radaszkiewicz T, Lechner K, Jaeger U (1996) Spontaneous remission of acute myeloid leukemia after infection and blood transfusion associated with hypergammaglobulinaemia. Ann Hematol 73:189–193PubMedCrossRef
4.
Ruggeri L, Capanni M, Casucci M, Volpi I, Tosti A, Perruccio K, Urbani E, Negrin RS, Martelli MF, Velardi A (1999) Role of natural killer cell alloreactivity in HLA-mismatched hematopoietic stem cell transplantation. Blood 94:333–339PubMed
5.
Berg T, Guo Y, Abdelkarim M, Fliegauf M, Lübbert M (2007) Reversal of p15/INK4b hypermethylation in AML1/ETO-positive and -negative myeloid leukemia cell lines. Leuk Res 497–506
6.
Scheibenbogen C, Letsch A, Thiel E, Schmittel A, Mailaender V, Baerwolf S et al (2002) CD8 T-cell responses to Wilms tumor gene product WT1 and proteinase 3 in patients with acute myeloid leukemia. Blood 100:2132–2137PubMedCrossRef
7.
Asemissen AM, Nagorsen D, Keilholz U, Letsch A, Schmittel A, Thiel E, Scheibenbogen C (2001) Flow cytometric determination of intracellular or secreted IFN gamma for the quantification of antigen reactive T cells. J Immunol Methods 251(1–2):101–108
8.
Penack O, Gentilini C, Fischer L, Asemissen AM, Scheibenbogen C, Thiel E, Uharek L (2005) CD56dimCD16neg cells are responsible for natural cytotoxicity against tumor targets. Leukemia 19:835–840
9.
Repp R, Borkhardt A, Haupt E, Kreuder J, Brettreich S, Hammermann J, Nishida K, Harbott J, Lampert F (1995) Detection of four different 11q23 chromosomal abnormalities by multiplex-PCR and fluorescence-based automatic DNA-fragment analysis. Leukemia 9:210–215
10.
Fernandes-Alnemri T, Litwack G, Alnemri ES (1994) CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme. J Biol Chem 269:30761–30764PubMed
11.
Piccaluga PP, Martinelli G, Malagola M, Rondoni M, Bianchini M, Visani G et al (2003) Complete remission in acute myeloid leukemia with granulocyte-colony stimulating factor without chemotherapy. Report of cytogenetic remission of a t(9;11)(p22;q23) positive AML patient and review of literature. Haematologica 88
12.
Maywald O, Buchheidt D, Bergmann J, Schoch C, Ludwig W-D, Reiter A, Hastka J, Lengfelder E, Hehlmann R (2004) Spontaneous remission in adult acute myeloid leukemia in association with systemic bacterial infection—case report and review of literature. Ann Hematol 83:189–194PubMedCrossRef
13.
Shimabukuro-Vornhagen A, Hallek MJ, Storb RF, von Bergwelt-Baildon MS (2009) The role of B cells in the pathogenesis of graft-versus-host disease. Blood 114:4919–4927PubMedCrossRef
Metadata
Title
Immune response as a possible mechanism of long-lasting disease control in spontaneous remission of MLL/AF9-positive acute myeloid leukemia
Authors
Claudia Müller-Schmah
Leticia Solari
Roland Weis
Dietmar Pfeifer
Carmen Scheibenbogen
Martin Trepel
Annette M. May
Rupert Engelhardt
Michael Lübbert
Publication date
01-01-2012
Publisher
Springer-Verlag
Published in
Annals of Hematology / Issue 1/2012
Print ISSN: 0939-5555
Electronic ISSN: 1432-0584
DOI
https://doi.org/10.1007/s00277-011-1332-y

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