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Open Access 01-12-2015 | Letter to the Editor

High expression of neuroguidin increases the sensitivity of acute myeloid leukemia cells to chemotherapeutic drugs

Authors: Kejun Chen, Shuqing Lü, Hui Cheng, Gusheng Tang, Min Liu, Hong Zhou, Jianmin Wang

Published in: Journal of Hematology & Oncology | Issue 1/2015

Abstract

Neuroguidin (NGDN) is a eukaryotic translation initiation factor 4E binding protein. The purpose of this study was to clarify the function of NGDN and its possible mechanism of action in human myeloid leukemia cells. Proliferation inhibition and apoptosis in NGDN over-expressing myeloid multidrug-resistant leukemia cells (K562/A02-NGDN) was significantly higher than in control K562/A02 cells following treatment with vincristine, etoposide, and epirubicin, indicating that NGDN over-expression can increase the sensitivity of multidrug-resistant leukemia cells to chemotherapeutic drugs. Furthermore, NGDN knock-down in K562/A02 cells resulted in the activation of multiple tumor-related signaling pathways, especially the mammalian target of rapamycin (mTOR) pathway.

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Title: High expression of neuroguidin increases the sensitivity of acute myeloid leukemia cells to chemotherapeutic drugs
Authors: Kejun Chen
Shuqing Lü
Hui Cheng
Gusheng Tang
Min Liu
Hong Zhou
Jianmin Wang
Publication date: 01-12-2015
Publisher: BioMed Central
Published in: Journal of Hematology & Oncology / Issue 1/2015
Electronic ISSN: 1756-8722
DOI: https://doi.org/10.1186/s13045-015-0108-6

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