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Molecular Neurodegeneration
Published in: Molecular Neurodegeneration 1/2015

Open Access 01-12-2015 | Review

Genetics ignite focus on microglial inflammation in Alzheimer’s disease

Authors: Manasi Malik, Ishita Parikh, Jared B. Vasquez, Conor Smith, Leon Tai, Guojun Bu, Mary Jo LaDu, David W. Fardo, G. William Rebeck, Steven Estus

Published in: Molecular Neurodegeneration | Issue 1/2015

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Abstract

In the past five years, a series of large-scale genetic studies have revealed novel risk factors for Alzheimer’s disease (AD). Analyses of these risk factors have focused attention upon the role of immune processes in AD, specifically microglial function. In this review, we discuss interpretation of genetic studies.  We then focus upon six genes implicated by AD genetics that impact microglial function: TREM2, CD33, CR1, ABCA7, SHIP1, and APOE. We review the literature regarding the biological functions of these six proteins and their putative role in AD pathogenesis. We then present a model for how these factors may interact to modulate microglial function in AD.
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Metadata
Title
Genetics ignite focus on microglial inflammation in Alzheimer’s disease
Authors
Manasi Malik
Ishita Parikh
Jared B. Vasquez
Conor Smith
Leon Tai
Guojun Bu
Mary Jo LaDu
David W. Fardo
G. William Rebeck
Steven Estus
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Molecular Neurodegeneration / Issue 1/2015
Electronic ISSN: 1750-1326
DOI
https://doi.org/10.1186/s13024-015-0048-1

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