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Chinese Medicine
Published in: Chinese Medicine 1/2018

Open Access 01-12-2018 | Review

Application of metabolomics in toxicity evaluation of traditional Chinese medicines

Authors: Li Duan, Long Guo, Lei Wang, Qiang Yin, Chen-Meng Zhang, Yu-Guang Zheng, E.-Hu Liu

Published in: Chinese Medicine | Issue 1/2018

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Abstract

Traditional Chinese medicines (TCM) have a long history of use because of its potential complementary therapy and fewer adverse effects. However, the toxicity and safety issues of TCM have drawn considerable attention in the past two decades. Metabolomics is an “omics” approach that aims to comprehensively analyze all metabolites in biological samples. In agreement with the holistic concept of TCM, metabolomics has shown great potential in efficacy and toxicity evaluation of TCM. Recently, a large amount of metabolomic researches have been devoted to exploring the mechanism of toxicity induced by TCM, such as hepatotoxicity, nephrotoxicity, and cardiotoxicity. In this paper, the application of metabolomics in toxicity evaluation of bioactive compounds, TCM extracts and TCM prescriptions are reviewed, and the potential problems and further perspectives for application of metabolomics in toxicological studies are also discussed.
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Metadata
Title
Application of metabolomics in toxicity evaluation of traditional Chinese medicines
Authors
Li Duan
Long Guo
Lei Wang
Qiang Yin
Chen-Meng Zhang
Yu-Guang Zheng
E.-Hu Liu
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Chinese Medicine / Issue 1/2018
Electronic ISSN: 1749-8546
DOI
https://doi.org/10.1186/s13020-018-0218-5

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