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Journal of Orthopaedic Surgery and Research

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Open Access 01-12-2019 | Knee Osteoarthritis | Research article

Intra-articular platelet-rich plasma injection for knee osteoarthritis: a summary of meta-analyses

Authors: Pu Chen, Liuwei Huang, Yufeng Ma, Dong Zhang, Xiaozhe Zhang, Jun Zhou, Anmin Ruan, Qingfu Wang

Published in: Journal of Orthopaedic Surgery and Research | Issue 1/2019

Abstract

Objective

The purpose of this study was (1) to perform a summary of meta-analyses comparing platelet-rich plasma (PRP) injection with hyaluronic acid (HA) and placebo injection for KOA patients, (2) to determine which meta-analysis provides the best available evidence to making proposals for the use of PRP in the treatment of KOA patients, and (3) to highlight gaps in the literature that require future investigation.

Material and methods

PubMed, EMBASE, and Cochrane databases search were performed for meta-analyses which compared PRP injection with HA or placebo. Clinical outcomes and adverse events were extracted from these meta-analyses. Meta-analysis quality was assessed using the Quality of Reporting of Meta-analyses (QUOROM) systems and the Oxman-Guyatt quality appraisal tool. The Jadad decision algorithm was also used to determine which meta-analysis provided the best available evidence.

Results

Four meta-analyses were included in our study, and all of these articles were Level I evidence. The QUOROM score of each included meta-analysis range from 14 to 17 points (mean score 15, maximum score 18), and the Oxman-Guyatt score range from 4 to 6 points (mean score 5, maximum score 7). Three meta-analyses indicated PRP showed more benefit in pain relief and functional improvement than the control group, and the other one suggested no difference between these groups. All included meta-analyses found no statistical difference in adverse events between these groups. In addition, a meta-analysis conducted by Shen et al. got the highest methodological quality score and suggested that PRP provided better pain relief and function improvement in the treatment of KOA.

Conclusions

For short-term follow-up (≤1 year), intra-articular PRP injection is more effective in terms of pain relief and function improvement in the treatment of KOA patients than HA and placebo, and there is no difference in the risk of an adverse event between PRP and HA or placebo.

Level of evidence

Level I evidence, a summary of meta-analyses

Trial registration

PROSPERO ID CRD42018116168

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Title: Intra-articular platelet-rich plasma injection for knee osteoarthritis: a summary of meta-analyses
Authors: Pu Chen
Liuwei Huang
Yufeng Ma
Dong Zhang
Xiaozhe Zhang
Jun Zhou
Anmin Ruan
Qingfu Wang
Publication date: 01-12-2019
Publisher: BioMed Central
Keywords: Knee Osteoarthritis
Knee Osteoarthritis
Published in: Journal of Orthopaedic Surgery and Research / Issue 1/2019
Electronic ISSN: 1749-799X
DOI: https://doi.org/10.1186/s13018-019-1363-y

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Intra-articular platelet-rich plasma injection for knee osteoarthritis: a summary of meta-analyses

Abstract

Objective

Material and methods

Results

Conclusions

Level of evidence

Trial registration

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Objective

Material and methods

Results

Conclusions

Level of evidence

Trial registration

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